vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v24i2.2899vsp-3727Research ArticleОРИГИНАЛЬНАЯ СТАТЬЯORIGINAL ARTICLESДебют сахарного диабета 1-го типа у детей, перенесших COVID-19: одномоментное исследованиеType 1 Diabetes Onset in Children after COVID-19: Cross-Sectional Studyhttps://orcid.org/0000-0001-9683-2829ЛазареваА. Н.LazarevaAnastasiya N.

Москва

Moscow

https://orcid.org/0000-0002-1456-8073РтищевА. Ю.RtishchevAlexey Yu.

Москва

Moscow

ВоронцоваИ. Г.VorontsovaIrina G.

Москва

Moscow

https://orcid.org/0000-0002-5591-813XРыбкинаИ. Г.RybkinaIrina G.

Москва

Moscow

https://orcid.org/0000-0002-8520-2378ПетряйкинаЕ. Е.PetryaykinaElena E.

Петряйкина Елена Ефимовна, доктор медицинских наук, заведующая кафедрой эндокринологии Института материнства и детства; врач детский эндокринолог эндокринологического отделения

 117997, Москва, ул. Островитянова, д. 1

Moscow

lepet_morozko@mail.ruДетская городская поликлиника № 122РоссияChildren’s City Outpatients Clinic No. 122Russian FederationМорозовская детская городская клиническая больница; Российский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияMorozovskaya Children’s City Hospital; Pirogov Russian National Research Medical UniversityRussian FederationРоссийский национальный исследовательский медицинский университет им. Н.И. Пирогова (Пироговский Университет)РоссияPirogov Russian National Research Medical UniversityRussian FederationМорозовская детская городская клиническая больницаРоссияMorozovskaya Children’s City HospitalRussian Federation2025180520252427682Copyright © Лазарева А.Н., Ртищев А.Ю., Воронцова И.Г., Рыбкина И.Г., Петряйкина Е.Е., 20252025Лазарева А.Н., Ртищев А.Ю., Воронцова И.Г., Рыбкина И.Г., Петряйкина Е.Е.Lazareva A.N., Rtishchev A.Y., Vorontsova I.G., Rybkina I.G., Petryaykina E.E.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/3727

В период пандемии COVID-19 была выдвинута гипотеза о связи перенесенной инфекции SARS-CoV-2 с развитием диабетического кетоацидоза (ДКА) у пациентов с впервые выявленным сахарным диабетом 1-го типа (СД1). Результаты проверки этой гипотезы остаются противоречивыми. Цель исследования — изучить ассоциацию перенесенного COVID-19 с клиническими характеристиками дебюта СД1 у детей. Методы. В исследование включали данные медицинской документации пациентов с впервые установленным СД1, госпитализированных в период с марта 2020 по март 2021 г. Основную группу составили пациенты с IgG к SARS-CoV-2 10 Ед/мл при поступлении в стационар, контрольную — пациенты без лабораторных признаков COVID-19. В числе характеристик СД1 регистрировали клиническую форму манифестации заболевания (гипергликемия, кетоз, ДКА), а также тяжесть ДКА на основании значений рН крови (легкая степень — рН 7,3; средняя степень — 7,1–7,2; тяжелая степень < 7,1). Результаты. Основную группу составили данные 119 детей, контрольную — 320 с впервые установленным СД1. Группы были сопоставимы по полу и возрасту. В основной группе у 35 (29,4%) пациентов СД1 манифестировал с гипергликемией, у 41 (34,5%) — с кетозом, у 43 (36,1%) — с ДКА; в контрольной группе такой дебют был отмечен у 81 (25,3%), 89 (27,8%) и 150 (46,9%) пациентов соответственно (р = 0,127). В основной группе ДКА легкой степени был у 9 (20,9%), средней степени — у 24 (55,8%), тяжелой степени — у 10 (23,3%); в контрольной группе — у 36 (24%), 73 (48,7%) и 41 (27,3%) пациента соответственно (р = 0,747). Заключение. Перенесенный COVID-19 не ассоциирован с клинической формой и тяжестью ДКА при манифестации СД1.

Background. The hypothesis on correlation between SARS-CoV-2 infection and diabetic ketoacidosis (DKA) development in patients with newly diagnosed type 1 diabetes (T1D) was proposed during the COVID-19 pandemic. The results of testing this hypothesis remain contradictory. Objective. Aim of the study — to analyse the correlation between COVID-19 and clinical characteristics of T1D onset in children. Methods. The study included data from the medical records of patients with newly diagnosed T1D and hospitalized from March 2020 to March 2021. The study group included patients with IgG to SARS-CoV-2 10 U/ml at hospital admission, control group — patients with no laboratory signs of COVID-19. Clinical forms of disease manifestation (hyperglycemia, ketosis, DKA) were recorded among T1D features, as well as DKA severity according to blood pH levels (mild — pH 7.3; moderate — pH = 7.1–7.2; severe — pH < 7.1). Results. The study group included data from 119 children, the control group — 320 with newly established T1D. Both groups were comparable in gender and age. T1D manifested with hyperglycemia in 35 (29.4%) patients, with ketosis — in 41 (34.5%), with DKA — in 43 (36.1%) in the study group; and in 81 (25.3%), 89 (27.8%) and 150 (46.9%) patients in the control group, respectively (p = 0.127). DKA was mild in 9 (20.9%), moderate in 24 (55.8%), and severe in 10 (23.3%) patients of study group; and in 36 (24%), 73 (48.7%) and 41 (27.3%) patients in the control group, respectively (p = 0.747). Conclusion: COVID-19 is not associated with the clinical form and severity of DKA at T1D onset.

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The authors declare that there are no conflicts of interest present.