vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i1.564vsp-375Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEРЕСПИРАТОРНЫЕ ПАТОГЕНЫ И ПРОТИВОИНФЕКЦИОННЫЙ ИММУНИТЕТ: ОСОБЕННОСТИ ВЗАИМОДЕЙСТВИЯ И ВОЗМОЖНОСТИ ТЕРАПИИ ТОПИЧЕСКИМ БАКТЕРИАЛЬНЫМ ЛИЗАТОМRESPIRATORY PATHOGENS AND ANTI-INFECTIVE IMMUNITY: PECULIARITIES OF THEIR INTERACTION AND OPPORTUNITIES OF THE TREATMENT WITH TOPICAL BACTERIAL LYSATEСелимзяноваЛ. Р.SelimzyanovaL. R.lilysir@mail.ruПромысловаЕ. А.PromyslovaE. А.lilysir@mail.ruВишнёваЕ. А.VishnevaE. А.lilysir@mail.ruНаучный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. Сеченова,РоссияScientific Centre of Children Health, RAMS, Moscow; I.M. Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Centre of Children Health, RAMS, MoscoRussian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Centre of Children Health, RAMS, MoscowRussian Federation201303022013121Вопросы современной педиатрии103107Copyright © Селимзянова Л.Р., Промыслова Е.А., Вишнёва Е.А., 20132013Селимзянова Л.Р., Промыслова Е.А., Вишнёва Е.А.Selimzyanova L.R., Promyslova E.А., Vishneva E.А.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/375

В статье анализируются данные об этиологии острых респираторных инфекций, особенностях влияния вирусов и бактерий на эпителий дыхательных путей и иммунный ответ макроорганизма. Рассмотрены основные проблемы терапии респираторных инфекций у детей. Представлен обзор результатов исследований по изучению механизмов действия, клинической эффективности и безопасности топического бактериального лизата при острых, рецидивирующих и хронических инфекционных заболеваниях респираторного тракта и ЛОР-органов у детей.

 

The article contains data about etiological characterization of respiratory infections, peculiarities of viruses and bacteria influence on the airway epithelium and human’s immune response. The main problems of respiratory infections treatment are considered. The article presents a review of mechanistic studies, efficacy and safety trials of the topical bacterial lysate in acute, recurrent and chronic infection respiratory and otorhinolaryngological diseases in children.

 

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The authors declare that there are no conflicts of interest present.