vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v12i1.578vsp-389Research ArticleВ ПОМОЩЬ ВРАЧУA DOCTOR’S AIDЭКЗОКРИННАЯ ПАНКРЕАТИЧЕСКАЯ НЕДОСТАТОЧНОСТЬ ПРИ САХАРНОМ ДИАБЕТЕ 1-ГО ТИПА У ДЕТЕЙ: НОВАЯ ПРОБЛЕМА ПЕДИАТРИЧЕСКОЙ ГАСТРОЭНТЕРОЛОГИИEXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGYНижевичА. А.NizhevichA. A.

Nizhevich Aleksandr Albertovich, PhD, MD, assistant lecturer, Chair of Hospital Pediatrics, Bashkortostan State Medical University, head out-of staff children’s gastroenterologist, Ministry of Health, Bashkortostan Republic. Address: 450000, Ufa, Lenina str., 3, Tel.: (347) 254-88-84, e-mail: aanj@yandex.ru

aanj@yandex.ruЯкуповаГ. М.YakupovaG. M.aanj@yandex.ruМалиевскийО. А.MalievskiiO. A.aanj@yandex.ruАхмадееваЭ. Н.AkhmadeevaE. N.aanj@yandex.ruФархутдиноваА. М.FarkhutdinovaA. M.aanj@yandex.ruБашкирский государственный медицинский университет, УфаРоссияBashkir State Medical University, the Republic of BashkortostanRussian FederationРеспубликанская детская клиническая больница, Уфа, Республика Башкортостан,РоссияChildren’s Republican Hospital, Ufa, the Republic of BashkortostanRussian Federation201303022013121Вопросы современной педиатрии181185Copyright © Нижевич А.А., Якупова Г.М., Малиевский О.А., Ахмадеева Э.Н., Фархутдинова А.М., 20132013Нижевич А.А., Якупова Г.М., Малиевский О.А., Ахмадеева Э.Н., Фархутдинова А.М.Nizhevich A.A., Yakupova G.M., Malievskii O.A., Akhmadeeva E.N., Farkhutdinova A.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/389

В статье представлены данные о наличии у части детей, страдающих сахарным диабетом 1-го типа, экзокринной панкреатической недостаточности. Показано, что применение заместительной ферментотерапии панкреатическими энзимами способствует ликвидации синдрома нарушенного переваривания пищи (мальдигестии) у данной группы детей. В статье также оценено значение определения фекальной эластазы 1 в качестве диагностического стандарта экзокринной панкреатической недостаточности у детей с сахарным диабетом 1-го типа.

One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion. The aim of the study was to evaluate the pancreatic exocrine secretion in children with type 1 diabetes mellitus with fecal elastase 1 test to estimate the possible need for exogenous pancreatic enzyme replacement therapy. The exocrine pancreatic function was evaluated in 54 diabetic children on the basis of steatocrite test and a determination of fecal elastase 1 concentrations. Compared to the controls, the diabetic children had significantly lower levels of fecal elastase 1 concentration (p<0,001). Steatorrhoea was registered in all patients with fecal elastase 1 level < 200 µg/g stool. All those patients were treated with pancreatin (creon) for 1 month. A reduction of fat excretion was observed in the pancreatin treated group at the end of the study. Pancreatin replacement therapy can be used safely in children with type 1 diabetes mellitus associated with exocrine pancreatic insufficiency.

 

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The authors declare that there are no conflicts of interest present.