vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v11i6.487vsp-397Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWМОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ НАРУШЕНИЯ РАЗВИТИЯ МОЗГА В ПРЕ- И НЕОНАТАЛЬНОМ ПЕРИОДЕMOLECULAR MECHANISMS OF NEURODEVELOPMENTAL ALTERATIONS IN PRENATAL AND NEONATAL PERIODSСалминаА. Б.SalminaA. B.allasalmina@mail.ruКомлеваЮ. К.KomlevaYu. K.allasalmina@mail.ruКувачеваН. В.KuvachevaN. V.allasalmina@mail.ruЛопатинаО. Л.LopatinaO. L.allasalmina@mail.ruИнжутоваА. И.InzhutovaA. I.allasalmina@mail.ruЧерепановС. М.CherepanovS. M.allasalmina@mail.ruЯузинаН. А.YauzinaN. A.allasalmina@mail.ruМорозоваГ. А.MorozovaG. A.allasalmina@mail.ruМалиновскаяН. А.MalinovskayaN. A.allasalmina@mail.ruПожиленковаЕ. А.PozhilenkovaE. A.allasalmina@mail.ruМоргунА. В.MorgunA. V.allasalmina@mail.ruТаранушенкоТ. Е.TaranushenkoT. E.allasalmina@mail.ruПетроваМ. М.PetrovaM. M.allasalmina@mail.ruКрасноярский государственный медицинский университет им. проф. В.Ф. Войно-ЯсенецкогоРоссияKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyRussian Federation201219112012116Вопросы современной педиатрии1520Copyright © Салмина А.Б., Комлева Ю.К., Кувачева Н.В., Лопатина О.Л., Инжутова А.И., Черепанов С.М., Яузина Н.А., Морозова Г.А., Малиновская Н.А., Пожиленкова Е.А., Моргун А.В., Таранушенко Т.Е., Петрова М.М., 20122012Салмина А.Б., Комлева Ю.К., Кувачева Н.В., Лопатина О.Л., Инжутова А.И., Черепанов С.М., Яузина Н.А., Морозова Г.А., Малиновская Н.А., Пожиленкова Е.А., Моргун А.В., Таранушенко Т.Е., Петрова М.М.Salmina A.B., Komleva Y.K., Kuvacheva N.V., Lopatina O.L., Inzhutova A.I., Cherepanov S.M., Yauzina N.A., Morozova G.A., Malinovskaya N.A., Pozhilenkova E.A., Morgun A.V., Taranushenko T.E., Petrova M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/397

Обзор литературы посвящен анализу современных представлений о молекулярных механизмах развития головного мозга в пре- и раннем постнатальном периоде, нарушение которых приводит к изменению нейропластичности и сложных форм поведения. Особый акцент сделан на роли окситоцина, механизмах нейрогенеза в регуляции развития мозга в норме, при стрессе раннего периода жизни и при пренатальном стрессе. Обсуждаются подходы к поиску молекул-маркеров и молекул-мишеней для диагностики и фармакологической коррекции нарушений развития головного мозга.

Review covers current data on molecular mechanisms of brain development in prenatal and early postnatal periods, and their alterations resulting in changes in neuroplasticity and behavioral pattern. Role of oxytocin, mechanisms of neurogenesis in normal conditions, in early-life stress and prenatal stress are in the special focus of the review. Novel approaches to searching the molecular markers and targets for diagnostics and pharmacological correction of neurodevelopmental disorders are discussed.

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The authors declare that there are no conflicts of interest present.