vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v11i6.491vsp-401Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESРОЛЬ НАСЛЕДСТВЕННОЙ ПРЕДРАСПОЛОЖЕННОСТИ В ФОРМИРОВАНИИ КОАРКТАЦИИ АОРТЫTHE ROLE OF THE HEREDITARY PREDISPOSITION IN THE DEVELOPMENT OF AORTA COARCTATIONТатариноваТ. Н.TatarinovaT. N.tatyanat.spb@mail.ruКостареваА. А.KostarevaA. A.tatyanat.spb@mail.ruГреховЕ. В.GrekhovE. V.tatyanat.spb@mail.ruМоисееваО. М.MoiseevaO. M.tatyanat.spb@mail.ruФедеральный центр сердца, крови и эндокринологии им. В.А. Алмазова, Санкт-ПетербургРоссияV.A. Almazov Federal Heart, Blood and Endocrinology Centre, St. PetersburgRussian Federation201219112012116Вопросы современной педиатрии4247Copyright © Татаринова Т.Н., Костарева А.А., Грехов Е.В., Моисеева О.М., 20122012Татаринова Т.Н., Костарева А.А., Грехов Е.В., Моисеева О.М.Tatarinova T.N., Kostareva A.A., Grekhov E.V., Moiseeva O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/401

В результате обследования семей больных с коарктацией аорты установлены факторы, предрасполагающие к развитию этого заболевания. В исследование было включено 68 пациентов с коарктацией аорты различной локализации, степени сужения и протяженности. Всем было выполнено эхокардиографическое исследование, непрямая и прямая манометрия, мультиспиральная компьютерная аортография, а также интраоперационная ревизия зоны коарктации. В 95,6% случаев выявлена типичная коарктация аорты, в 55,9% коарктация аорты сочеталась с двустворчатым аортальным клапаном. Наибольшее значение для развития порока имели отягощенная наследственность (33,8%) и осложненное течение беременности (57,4%). По данным исследования установлено, что при планировании беременности важно обследовать обоих родителей, т.к. в развитии коарктации аорты наличие патологических состояний у отца, возможно, имеет большее значение, чем подобная патология у матери. Детям с отягощенной наследственностью по врожденным порокам сердца рекомендовано выполнять эхокардиографическое исследование в ранние сроки после рождения, несмотря на отсутствие патологии при выполнении ультразвукового исследования плода.

As a result of examination of the families of patients with aorta coarctation the factors predisposing to this condition were established. Sixty eight patients with different localization, stenosis degree and extent of aorta coarctation were included into this study. All the patients were performed echocardiography, indirect and direct. Typical coarctation was found in 95,6% of the cases, in 55,9% it was associated with bicuspid aortic valve. The most significant predisposing factors to this anomaly development were compromised hereditary (33,8%) and complications during pregnancy (57,4%). According to the received data, during the family planning it is important to examine both parents, as father’s disorders may have more marked impact on aorta coarctation development, than mother’s ones. Children with compromised heredity on congenital heart defects are recommended to be carried out echocardiographic investigation at the early period of time after birth, despite the absence of disorders on intrauterine ultrasound.

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The authors declare that there are no conflicts of interest present.