vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v25i3.3061vsp-4050Research ArticleКЛИНИЧЕСКОЕ НАБЛЮДЕНИЕCLINICAL OBSERVATIONSТрудности дифференциальной диагностики транзиторной ишемической атаки с мигренью с аурой у подростка 14 лет: клинический случайChallenges in the Differential Diagnosis of Transitory Ischemic Attack and Migraine with Aura in 14-Year-Old Adolescent: Case Studyhttps://orcid.org/0009-0000-2166-0882НасыроваЛ. О.NasyrovaLolita O.

Екатеринбург

Yekaterinburg

https://orcid.org/0009-0009-0795-8370CкурихинаМ. Д.SkurikhinaMariya D.

Екатеринбург

Yekaterinburg

https://orcid.org/0000-0002-1903-4388ГородничеваА. В.GorodnichevaAnna V.

Городничева Анна Вадимовна, ассистент кафедры неврологии и нейрохирургии 

620028, Екатеринбург, ул. Репина, д. 3

Yekaterinburg

agorodnicheva99@gmail.comhttps://orcid.org/0000-0002-2280-3096ЛьвоваО. А.L’vovaOlga A.

Екатеринбург

Yekaterinburg

https://orcid.org/0000-0003-2232-7074ГусевВ. В.GusevVadim V.

Екатеринбург

Yekaterinburg

https://orcid.org/0009-0008-0317-8919ШамкинА. С.ShamkinAlexey S.

Екатеринбург

Yekaterinburg

https://orcid.org/0000-0001-8392-3027ПукисП. Э.PukisPolina E.

Екатеринбург

Yekaterinburg

https://orcid.org/0000-0002-3366-6832ЗенгерМ. Е.ZengerMarina E.

Екатеринбург

Yekaterinburg

Уральский государственный медицинский университетРоссияUral State Medical UniversityRussian FederationДетская городская клиническая больница № 9; Уральский федеральный университет им. первого Президента России Б.Н. ЕльцинаРоссияChildren’s City Clinical Hospital No. 9; Ural Federal University named after the first President of Russia B.N. YeltsinRussian Federation202621072026253195–206Copyright © Насырова Л.О., Cкурихина М.Д., Городничева А.В., Львова О.А., Гусев В.В., Шамкин А.С., Пукис П.Э., Зенгер М.Е., 20262026Насырова Л.О., Cкурихина М.Д., Городничева А.В., Львова О.А., Гусев В.В., Шамкин А.С., Пукис П.Э., Зенгер М.Е.Nasyrova L.O., Skurikhina M.D., Gorodnicheva A.V., L’vova O.A., Gusev V.V., Shamkin A.S., Pukis P.E., Zenger M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/4050

Обоснование. Транзиторные ишемические атаки (ТИА) остаются значимой проблемой здравоохранения в детской популяции. Трудности диагностики ТИА у детей и высокий риск рецидивирования (до 40%) обусловлены отсутствием стандартов ведения таких пациентов, а также схожестью клинической картины ТИА с другими пароксизмальными состояниями (например, мигренью с аурой).

Описание клинического случая. Девочка, возраст 14 лет, поступила в стационар по месту жительства с жалобами на приступы головной боли, ухудшение зрения («светлая линия» в левом поле зрения) и онемение левой кисти длительностью до 2,5 ч. Диагностирована мигрень с аурой. При обследовании выявлены носительство вариантов шести генов (FGB, F13, ITGA2, PAI-1, MTR, MTRR), ассоциированных с тромбофилией, а также гипоплазия правой позвоночной артерии, аномалия Киммерле с экстравазальной компрессией, дефект межпредсердной перегородки и брадикардия. Диагностированы рецидивирующие ТИА в вертебробазилярном бассейне. Назначена ацетилсалициловая кислота (75 мг/сут) по показанию off-label с полным купированием эпизодов ТИА в течение 2 лет. Отмена препарата спровоцировала рецидив ТИА. Возобновление антиагрегантной терапии обеспечило наступление клинической ремиссии. Заключение. Диагностика ТИА у детей — сложная клиническая задача, требующая исключения широкого спектра заболеваний (мигрень с аурой, эпилепсия, демиелинизирующие заболевания). Своевременная диагностика ТИА требует сохранения настороженности врачей в отношении цереброваскулярной патологии, междисциплинарного этапного подхода, анализа факторов риска (тромбофильные варианты генов, аномалии сосудов, кардиальная патология). Назначение антиагрегантной терапии детям с ТИА требует проведения лабораторного контроля эффективности (ASPI-тест), а отмена терапии — оценки соотношения риск/ польза ввиду высокого риска рецидива.

Background

Background. Transitory ischemic attacks (TIA) remain a significant public health problem in the pediatric population. The difficulties of diagnostics of TIA in children and the high risk of recurrence (up to 40%) are due to the lack of standards for the patients management, as well as the similarity of the clinical manifestations of TIA with other paroxysmal states (migraine with aura, for example).

Case description

Case description. A 14-year-old girl was admitted to the hospital in the home area, complaints: headaches, blurred vision (a “light line” in the left F.V.), numb feeling of the left hand, lasts up to 2.5 hours. Diagnosis: migraine with aura. At the checkup the carrier state of variants of six genes (FGB, F13, ITGA2, PAI-1, MTR, MTRR) associated with thrombophilia was revealed, as well as hypoplasia of the right vertebral artery, Kimmerle anomaly with extravasal compression, atrial septal defect, and bradycardia. Recurrent TIAs were diagnosed in the vertebrobasilar territory. Acidum acetylsalicylicum (75 mg/day) was prescribed as per the off-label, with complete relief of TIA episodes for 2 years. Withdrawal of the drug provoked a recurrence of TIA. The resumption of Antiplatelet therapy ensured the onset of remission.

Conclusion

Conclusion. Diagnostics of TIA in children is a complex clinical case which requires to exclude a wide range of diseases (migraine with aura, epilepsy, demyelinating diseases). To diagnose the TIA promptly doctors need to remain alert to cerebrovascular pathology, they also need an interdisciplinary step-by-step approach, and analyze the risk factors (thrombophilic gene variants, vascular anomalies, and cardiac pathology). When prescribing antiplatelet therapy to children with TIA doctors conduct the laboratory efficacy monitoring (ASPI test), when discontinuing the therapy doctors assess the risk/benefit ratio due to high risk of relapse.

транзиторная ишемическая атакаподросткизрительные нарушенияоптическая когерентная томографияантиагрегантная терапияtransitory ischemic attackadolescentsvisual impairmentsoptical coherence tomographyantiplatelet therapyОтсутствует.Not specified.ReferencesИшемический инсульт и транзиторная ишемическая атака: клинические рекомендации. — Минздрав России; 2024. — 385 с.Ishemicheskii insul’t i tranzitornaya ishemicheskaya ataka: Clinical guidelines. Ministry of Health of the Russian Federation; 2024. 385 p. (In Russ).]Prabhakaran S, Gonzalez NR, Zachrison KS, et al. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2026. doi: https://doi.org/10.1161/STR.0000000000000513Prabhakaran S, Gonzalez NR, Zachrison KS, et al. 2026 Guideline for the Early Management of Patients With Acute Ischemic Stroke: A Guideline From the American Heart Association/American Stroke Association. Stroke. 2026. doi: https://doi.org/10.1161/STR.0000000000000513Lehman LL, Watson CG, Kapur K, et al. Predictors of Stroke After Transient Ischemic Attack in Children. Stroke. 2016;47(1):88–93. doi: https://doi.org/10.1161/STROKEAHA.115.009904Lehman LL, Watson CG, Kapur K, et al. Predictors of Stroke After Transient Ischemic Attack in Children. Stroke. 2016;47(1):88–93. doi: https://doi.org/10.1161/STROKEAHA.115.009904Михалюк Р.А. Транзиторная ишемическая атака как предиктор ишемического инсульта // Рецепт. — 2021. — Т. 24. — № 6. — С. 858–864. — doi: https://doi.org/10.34883/PI.2021.24.6.009Mikhaliuk RA. Transient ischemic attack as a predictor ischemic stroke. Recipe. 2021;24(6):858–864. (In Russ). doi: https://doi.org/10.34883/PI.2021.24.6.009]Fullerton HJ, Wintermark M, Hills NK, et al. Risk of Recurrent Arterial Ischemic Stroke in Childhood: A Prospective International Study. Stroke. 2016;47(1):53–59. doi: https://doi.org/10.1161/STROKEAHA.115.011173Fullerton HJ, Wintermark M, Hills NK, et al. Risk of Recurrent Arterial Ischemic Stroke in Childhood: A Prospective International Study. Stroke. 2016;47(1):53–59. doi: https://doi.org/10.1161/STROKEAHA.115.011173Rodan L, McCrindle BW, Manlhiot C, et al. Stroke recurrence in children with congenital heart disease. Ann Neurol. 2012;72(1): 103–111. doi: https://doi.org/10.1002/ana.23574Rodan L, McCrindle BW, Manlhiot C, et al. Stroke recurrence in children with congenital heart disease. Ann Neurol. 2012;72(1): 103–111. doi: https://doi.org/10.1002/ana.23574Kumar R, Sun LR, Rodriguez V, et al. Hemostatic and Thrombotic Considerations in the Diagnosis and Management of Childhood Arterial Ischemic Stroke: A Narrative Review. Semin Pediatr Neurol. 2022;43:101003. doi: https://doi.org/10.1016/j.spen.2022.101003Kumar R, Sun LR, Rodriguez V, et al. Hemostatic and Thrombotic Considerations in the Diagnosis and Management of Childhood Arterial Ischemic Stroke: A Narrative Review. Semin Pediatr Neurol. 2022;43:101003. doi: https://doi.org/10.1016/j.spen.2022.101003Ferriero D, Fullerton H, Bernard T, et al. Management of stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke. 2019;50(3): 51–96. doi: https://doi.org/10.1161/STR.0000000000000183Ferriero D, Fullerton H, Bernard T, et al. Management of stroke in neonates and children: a scientific statement from the American Heart Association/American Stroke Association. Stroke. 2019;50(3): 51–96. doi: https://doi.org/10.1161/STR.0000000000000183Fileva N, Bertamino M, Tortora D, Severino M. Arterial Ischemic Stroke in Children. Neuroimaging Clin N Am. 2024;34(4):579–599. doi: https://doi.org/10.1016/j.nic.2024.08.010Fileva N, Bertamino M, Tortora D, Severino M. Arterial Ischemic Stroke in Children. Neuroimaging Clin N Am. 2024;34(4):579–599. doi: https://doi.org/10.1016/j.nic.2024.08.010Hasbani GE, Taher AT, Sunji N, et al. Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to many questions. Lupus. 2021;30(9):1365–1377. doi: https://doi.org/10.1177/09612033211021488Hasbani GE, Taher AT, Sunji N, et al. Antiphospholipid antibodies and cerebrovascular thrombosis in the pediatric population: Few answers to many questions. Lupus. 2021;30(9):1365–1377. doi: https://doi.org/10.1177/09612033211021488Das BB. Patent Foramen Ovale in Fetal Life, Infancy and Childhood. Med Sci (Basel). 2020;8(3):25. doi: https://doi.org/10.3390/medsci8030025Das BB. Patent Foramen Ovale in Fetal Life, Infancy and Childhood. Med Sci (Basel). 2020;8(3):25. doi: https://doi.org/10.3390/medsci8030025Yelton SEG, Flores S, Sun LR, et al. Association Between Congenital Heart Disease and Stroke: Insights from a National Database. Pediatr Cardiol. 2024;45(1):1–7. doi: https://doi.org/10.1007/s00246-023-03315-6Yelton SEG, Flores S, Sun LR, et al. Association Between Congenital Heart Disease and Stroke: Insights from a National Database. Pediatr Cardiol. 2024;45(1):1–7. doi: https://doi.org/10.1007/s00246-023-03315-6Chung MG, Guilliams KP, Wilson JL, et al. Arterial Ischemic Stroke Secondary to Cardiac Disease in Neonates and Children. Pediatr Neurol. 2019;100:35–41. doi: https://doi.org/10.1016/j.pediatrneurol.2019.06.008Chung MG, Guilliams KP, Wilson JL, et al. Arterial Ischemic Stroke Secondary to Cardiac Disease in Neonates and Children. Pediatr Neurol. 2019;100:35–41. doi: https://doi.org/10.1016/j.pediatrneurol.2019.06.008Львова О.А. Ишемические инсульты и транзиторные ишемические атаки у детей: клинические и молекулярно-генетические аспекты течения, прогнозирование исходов, тактика динамического наблюдения: дис. … докт. мед. наук. — Екатеринбург; 2017. — 249 с.Lvova OA. Ishemicheskie insul’ty i tranzitornye ishemicheskie ataki u detei: klinicheskie i molekulyarnogeneticheskie aspekty techeniya, prognozirovanie iskhodov, taktika dinamicheskogo nablyudeniya. [dissertation]. Yekaterinburg; 2017. 249 p. (In Russ).]Terni E, Giannini N, Brondi M, et al. Genetics of ischaemic stroke in young adults. BBA Clinical. 2014;3:96–106. doi: https://doi.org/10.1016/j.bbacli.2014.12.004Terni E, Giannini N, Brondi M, et al. Genetics of ischaemic stroke in young adults. BBA Clinical. 2014;3:96–106. doi: https://doi.org/10.1016/j.bbacli.2014.12.004Гусев В.В. Ишемический инсульт в нетипичном возрасте: предиктивное значение факторов риска, клинические и молекулярно-генетические показатели прогноза и формирования исходов: дис … докт. мед. наук. — Екатеринбург; 2024. — 216 с.Gusev VV. Ishemicheskii insul’t v netipichnom vozraste: prediktivnoe znachenie faktorov riska, klinicheskie i molekulyarno-geneticheskie pokazateli prognoza i formirovaniya iskhodov. [dissertation]. Yekaterinburg; 2024. 216 p. (In Russ).]Gupta N, Muthusami P, Pai V, Shroff M. Arterial Ischemic Stroke in Children: Navigating Diagnostic and Management Pathways. Radiographics. 2025;45(10):e250017. doi: https://doi.org/10.1148/rg.250017Gupta N, Muthusami P, Pai V, Shroff M. Arterial Ischemic Stroke in Children: Navigating Diagnostic and Management Pathways. Radiographics. 2025;45(10):e250017. doi: https://doi.org/10.1148/rg.250017Pearson R, Hills NK, Bacon K, et al. Striving toward quality metrics for pediatric stroke: time from door to diagnosis. Front Stroke. 2026;4:1718355. doi: https://doi.org/10.3389/fstro.2025.1718355Pearson R, Hills NK, Bacon K, et al. Striving toward quality metrics for pediatric stroke: time from door to diagnosis. Front Stroke. 2026;4:1718355. doi: https://doi.org/10.3389/fstro.2025.1718355Bowers KJ, Deveber GA, Ferriero DM, et al. Cerebrovascular disease in children: recent advances in diagnosis and management. J Child Neurol. 2011;26(9):1074–1100. doi: https://doi.org/10.1177/0883073811413585Bowers KJ, Deveber GA, Ferriero DM, et al. Cerebrovascular disease in children: recent advances in diagnosis and management. J Child Neurol. 2011;26(9):1074–1100. doi: https://doi.org/10.1177/0883073811413585Pohl M, Hesszenberger D, Kapus K, et al. Ischemic stroke mimics: A comprehensive review. J Clin Neurosci. 2021;93: 174–182. doi: https://doi.org/10.1016/j.jocn.2021.09.025Pohl M, Hesszenberger D, Kapus K, et al. Ischemic stroke mimics: A comprehensive review. J Clin Neurosci. 2021;93: 174–182. doi: https://doi.org/10.1016/j.jocn.2021.09.025Львова О.А., Гусев В.В. Место дезагрегантов в системе вторичной профилактики ишемического инсульта у детей и молодых больных // Фарматека. — 2014. — № 13. — С. 26–30.Lvova OA, Gusev VV. Mesto dezagregantov v sisteme vtorichnoi profilaktiki ishemicheskogo insul’ta u detei i molodykh bol’nykh. Farmateka. 2014;(13):26–30. (In Russ).]Uohara MY, Beslow LA, Billinghurst L, et al. Incidence of recurrence in posterior circulation childhood arterial ischemic stroke. JAMA Neurology. 2017;74(3):316–323. doi: https://doi.org/10.1001/jamaneurol.2016.5526Uohara MY, Beslow LA, Billinghurst L, et al. Incidence of recurrence in posterior circulation childhood arterial ischemic stroke. JAMA Neurology. 2017;74(3):316–323. doi: https://doi.org/10.1001/jamaneurol.2016.5526Мигрень у детей: клинические рекомендации. — Минздрав России; 2024. — 54 с. [Migren’ u detei: Clinical recommendations. Ministry of Health of the Russian Federation; 2024. 54 p. (In Russ).]Migren’ u detei: Clinical recommendations. Ministry of Health of the Russian Federation; 2024. 54 p. (In Russ).]Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. doi: https://doi.org/10.1177/0333102417738202Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38(1):1–211. doi: https://doi.org/10.1177/0333102417738202Ciechanowska M, Stachurski J. Differential diagnosis of stroke, transient ischemic attack, and hemiplegic migraine in an adolescent patient. Medical Science Pulse. 2021;15(2):1–5. doi: https://doi.org/10.5604/01.3001.0015.0631Ciechanowska M, Stachurski J. Differential diagnosis of stroke, transient ischemic attack, and hemiplegic migraine in an adolescent patient. Medical Science Pulse. 2021;15(2):1–5. doi: https://doi.org/10.5604/01.3001.0015.0631Edwards CL, Membreno Lopez AS, Green C, et al. Hemiplegic Migraine in Children: Clinical Presentation, Diagnosis, and Management Challenges in Pediatric Practice. Japanese Journal of Medical Research. 2026;4(1):1–14. doi: https://doi.org/10.33425/2993-6799.1034Edwards CL, Membreno Lopez AS, Green C, et al. Hemiplegic Migraine in Children: Clinical Presentation, Diagnosis, and Management Challenges in Pediatric Practice. Japanese Journal of Medical Research. 2026;4(1):1–14. doi: https://doi.org/10.33425/2993-6799.1034Rothwell PM, Giles MF, Flossmann E, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005;366(9479):29–36. doi: https://doi.org/10.1016/S0140-6736(05)66702-5Rothwell PM, Giles MF, Flossmann E, et al. A simple score (ABCD) to identify individuals at high early risk of stroke after transient ischaemic attack. Lancet. 2005;366(9479):29–36. doi: https://doi.org/10.1016/S0140-6736(05)66702-5Шкала ABCD2 // Общество доказательной неврологии: вебсайт. [ABCD2 scale. In: Society for Evidence-Based Neuroscience: Website. (In Russ).] Доступно по: https://evidence-neurology.ru/medical-calculators/hemorrhage/abcd2. Ссылка активна на 15.05.2026.ABCD2 scale. In: Society for Evidence-Based Neuroscience: Website. (In Russ).] Доступно по: https://evidence-neurology.ru/medical-calculators/hemorrhage/abcd2. Ссылка активна на 15.05.2026.Al-Khaled M, Eggers J. MRI findings and stroke risk in TIA patients with different symptom durations. Neurology. 2013;80(21):1920–1926. doi: https://doi.org/10.1212/WNL.0b013e318293e15fAl-Khaled M, Eggers J. MRI findings and stroke risk in TIA patients with different symptom durations. Neurology. 2013;80(21):1920–1926. doi: https://doi.org/10.1212/WNL.0b013e318293e15fJohnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007;369(9558):283–292. doi: https://doi.org/10.1016/S0140-6736(07)60150-0Johnston SC, Rothwell PM, Nguyen-Huynh MN, et al. Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack. Lancet. 2007;369(9558):283–292. doi: https://doi.org/10.1016/S0140-6736(07)60150-0Кулеш А.А. Транзиторная ишемическая атака в вертебробазилярном бассейне как причина изолированного головокружения // Неврология, нейропсихиатрия, психосоматика. — 2024. — Т. 16. — № 1. — С. 16–23. — doi: https://doi.org/10.14412/2074-2711-2024-1-16-23Kulesh AA. Transient ischemic attack in the vertebrobasilar basin as a cause of isolated vertigo. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, neuropsychiatry, psychosomatics. 2024;16(1):16–23. (In Russ). doi: https://doi.org/10.14412/2074-2711-2024-1-16-23]Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10(5):457–470. doi: https://doi.org/10.1016/S1474-4422(11)70048-5Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol. 2011;10(5):457–470. doi: https://doi.org/10.1016/S1474-4422(11)70048-5Barone V, Foschi M, Pavolucci L, et al. Enhancing stroke risk prediction in patients with transient ischemic attack: insights from a prospective cohort study implementing fast-track care. Front Neurol. 2024;15:1407598. doi: https://doi.org/10.3389/fneur.2024.1407598Barone V, Foschi M, Pavolucci L, et al. Enhancing stroke risk prediction in patients with transient ischemic attack: insights from a prospective cohort study implementing fast-track care. Front Neurol. 2024;15:1407598. doi: https://doi.org/10.3389/fneur.2024.1407598Palaiodimou L, Katsanos AH, Melanis K, et al. Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and metaanalysis. Eur Stroke J. 2025;10(4):1221–1230. doi: https://doi.org/10.1177/23969873251334278Palaiodimou L, Katsanos AH, Melanis K, et al. Recurrent stroke in patients with history of stroke/transient ischemic attack and device-detected atrial fibrillation: A systematic review and metaanalysis. Eur Stroke J. 2025;10(4):1221–1230. doi: https://doi.org/10.1177/23969873251334278Wu G, Xi Y, Yao L, et al. Genetic polymorphism of ITGA2 C807T can increase the risk of ischemic stroke. Int J Neurosci. 2014;124(11):841–851. doi: https://doi.org/10.3109/00207454.2013.879718Wu G, Xi Y, Yao L, et al. Genetic polymorphism of ITGA2 C807T can increase the risk of ischemic stroke. Int J Neurosci. 2014;124(11):841–851. doi: https://doi.org/10.3109/00207454.2013.879718Цыганенко О.В., Волкова Л.И., Алашеев А.М. Клинические особенности ишемических инсультов в молодом возрасте при носительстве полиморфизма метионин-синтазы-редуктазы A66G // Неврология, нейропсихиатрия, психосоматика. — 2021. — Т. 13. — № 4. — С. 25–29. — doi: https://doi.org/10.14412/2074-2711-2021-4-25-29Tsyganenko OV, Volkova LI, Alasheev AM. Methionine synthase reductase A66G polymorphism and ischemic stroke in younger patients. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2021;13(4):25–29. (In Russ). doi: https://doi.org/10.14412/2074-2711-2021-4-25-29]Кулеш А.А., Дробаха В.Е., Шестаков В.В. Криптогенный инсульт // Неврология, нейропсихиатрия, психосоматика. — 2019. — Т. 11. — № 4. — С. 14–21. — doi: https://doi.org/10.14412/2074-2711-2019-4-14-21Kulesh AA, Drobakha VE, Shestakov VV. Cryptogenic stroke. Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, Neuropsychiatry, Psychosomatics. 2019;11(4):14–21. (In Russ). doi: https://doi.org/10.14412/2074-2711-2019-4-14-21]Clissold B, Phan TG, Ly J, et al. Current aspects of TIA management. J Clin Neurosci. 2020;72:20–25. doi: https://doi.org/10.1016/j.jocn.2019.12.032Clissold B, Phan TG, Ly J, et al. Current aspects of TIA management. J Clin Neurosci. 2020;72:20–25. doi: https://doi.org/10.1016/j.jocn.2019.12.032Dattilo M, Newman NJ, Biousse V. Acute retinal arterial ischemia. Ann Eye Sci. 2018;3:28. doi: https://doi.org/10.21037/aes.2018.05.04Dattilo M, Newman NJ, Biousse V. Acute retinal arterial ischemia. Ann Eye Sci. 2018;3:28. doi: https://doi.org/10.21037/aes.2018.05.04Kaur K, Najem K, Margolin E. Amaurosis Fugax. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026.Kaur K, Najem K, Margolin E. Amaurosis Fugax. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2026.Городничева А.В., Львова О.А., Шамкин А.С. Результаты пилотного исследования сетчатки методом оптической когерентной томографии у подростков после транзиторной ишемической атаки со зрительными нарушениями // Медицинское образование, наука, практика: Сборник статей X Международной научно-практической конференции молодых ученых и студентов. — 2025. — Т. 2. — С. 590–594.Gorodnicheva AV, Lvova OA, Shamkin AS. The results of a pilot study of the retina using optical coherence tomography in adolescents after a transient ischemic attack with visual impairments. Medical education, science, practice: Collection of articles of the X International Scientific and Practical Conference of Young Scientists and Students. 2025;2:590–594. (In Russ).]Schrör K. Aspirin and Reye syndrome: a review of the evidence. Pediatric Drugs. 2007;9(3):195–204. doi: https://doi.org/10.2165/00148581-200709030-00008Schrör K. Aspirin and Reye syndrome: a review of the evidence. Pediatric Drugs. 2007;9(3):195–204. doi: https://doi.org/10.2165/00148581-200709030-00008Pedersen SB, Grove EL, Nielsen HL, et al. Evaluation of aspirin response by Multiplate whole blood aggregometry and light transmission aggregometry. Platelets. 2009;20(6):415–420. doi: https://doi.org/10.1080/09537100903100643Pedersen SB, Grove EL, Nielsen HL, et al. Evaluation of aspirin response by Multiplate whole blood aggregometry and light transmission aggregometry. Platelets. 2009;20(6):415–420. doi: https://doi.org/10.1080/09537100903100643Mueller T, Dieplinger B, Poelz W, Haltmayer M. Utility of the PFA100 instrument and the novel multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease. Clin Appl Thromb Hemost. 2009;15(6): 652–659. doi: https://doi.org/10.1177/1076029608322547Mueller T, Dieplinger B, Poelz W, Haltmayer M. Utility of the PFA100 instrument and the novel multiplate analyzer for the assessment of aspirin and clopidogrel effects on platelet function in patients with cardiovascular disease. Clin Appl Thromb Hemost. 2009;15(6): 652–659. doi: https://doi.org/10.1177/1076029608322547Würtz M, Hvas AM, Christensen KH, et al. Rapid evaluation of platelet function using the Multiplate Analyzer. Platelets. 2013;25(8):628–633. doi: https://doi.org/10.3109/09537104.2013.849804Würtz M, Hvas AM, Christensen KH, et al. Rapid evaluation of platelet function using the Multiplate Analyzer. Platelets. 2013;25(8):628–633. doi: https://doi.org/10.3109/09537104.2013.849804

The authors declare that there are no conflicts of interest present.