vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v11i5.423vsp-422Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESСЕКРЕЦИЯ МЕЛАТОНИНА И ГИПЕРСОМНИЯ У ДЕТЕЙ И ПОДРОСТКОВ ПОСЛЕ УДАЛЕНИЯ КРАНИОФАРИНГИОМЫMELATONIN SECRETION AND HYPERSOMNIA IN CHILDREN AND ADOLESCENTS AFTER CRANIOPHARYNGIOMA RESECTIONИльинаЕ. Ю.Il'inaE. Yu.

Ильина Елена Юрьевна, аспирант кафедры эндокринологии и диабетологии педиатрического факультета Первого МГМУ им. И.М. Сеченова

el_ilina@mail.ruСтребковаН. А.StrebkovaN. A.el_ilina@mail.ruПетерковаВ. А.PeterkovaV. A.el_ilina@mail.ruПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical University,Russian FederationИнститут детской эндокринологии ФГБУ ЭНЦ, МоскваРоссияInstitute of Pediatric Endocrinology of the FSFI ESC, MoscowRussian FederationИнститут детской эндокринологии ФГБУ ЭНЦ, МоскваРоссияInstitute of Pediatric Endocrinology of the FSFI ESC, Moscow, Russian FederationRussian Federation201219092012115Вопросы современной педиатрии1923Copyright © Ильина Е.Ю., Стребкова Н.А., Петеркова В.А., 20122012Ильина Е.Ю., Стребкова Н.А., Петеркова В.А.Il'ina E.Y., Strebkova N.A., Peterkova V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/422

Краниофарингиома — редкая эмбриогенная опухоль хиазмально-селлярной области с низкой степенью малигнизации и высокой частотой рецидивирования. Несмотря на благоприятный исход и удовлетворительные результаты лечения, качество жизни пациентов снижается из-за осложнений, связанных с анатомической близостью краниофарингиомы к зрительному нерву, зрительной хиазме, гипофизу и гипоталамусу. Развитие гипоталамического ожирения наблюдается у 25–60% детей и подростков после хирургического лечения краниофарингиомы, которое, как правило, сопровождается выраженными нарушениями суточного ритма и оказывает наиболее весомое отрицательное влияние на качество жизни пациентов.

Craniopharyngioma is a rare embryonic tumor of the chiasm-sellar region with low malignancy rate but high frequency of recurrence. In spite of the favorable outcome and satisfactory results of treatment the patients quality of life worsens due to complications associated with anatomic localization of craniopharyngioma close to the optic nerve, optic chiasm, hypophysis and hypothalamus. The development of hypothalamic obesity is observed in 25–60% of children and adolescents after surgical treatment of craniopharyngioma, which is usually accompanied with significant disturbances of circadian rhythm and has the most important influence on patients quality of life.

краниофарингиомагипоталамическое ожирениегипоталамуссекреция мелатонинагиперсомнияcraniopharyngiomahypothalamic obesityhypothalamusmelatonin secretionhypersomniaReferencesMuller H. L., Kaatsch P., Warmuth-Metz M. et al. Childhood craniopharyngioma — diagnostic and therapeutic strategies. Monatsschr. Kinderheilkunde. 2003; 151: 1056–1063.Muller H. L., Kaatsch P., Warmuth-Metz M. et al. Childhood craniopharyngioma — diagnostic and therapeutic strategies. Monatsschr. Kinderheilkunde. 2003; 151: 1056–1063.Muller H. L. et al. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm. Res. 2008; 69: 193–202.Muller H. L. et al. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm. Res. 2008; 69: 193–202.Muller H. L. et al. Childhood craniopharyngioma: current strategies in laboratory diagnostics and endocrine treatment. Lab. Med. 2003; 27: 377–385.Muller H. L. et al. Childhood craniopharyngioma: current strategies in laboratory diagnostics and endocrine treatment. Lab. Med. 2003; 27: 377–385.Fahlbusch R., Honegger J., Paulus W. et al. Surgical management of craniopharyngiomas: experience with 168 patients. J. Neuro surg. 1999; 90: 237–250.Fahlbusch R., Honegger J., Paulus W. et al. Surgical management of craniopharyngiomas: experience with 168 patients. J. Neuro surg. 1999; 90: 237–250.Muller H. L., Bueb K., Bartels U. et al. Obesity after childhood craniopharyngioma — German multicenter study on preoperative risk factors and quality of life. Klin. Padiatr. 2001; 213: 244–249. Medline. doi:10.1055/s-2001-16855.Muller H. L., Bueb K., Bartels U. et al. Obesity after childhood craniopharyngioma — German multicenter study on preoperative risk factors and quality of life. Klin. Padiatr. 2001; 213: 244–249. Medline. doi:10.1055/s-2001-16855.Brzezinski A. et al. Melatonin in humans. N. Eng. J. Med. 1997; 336 (3): 186–195.Brzezinski A. et al. Melatonin in humans. N. Eng. J. Med. 1997; 336 (3): 186–195.Hardeland R. et al. Melatonin, hormone of darkness and more — occurrence, control mechanisms, actions, and bioactive metabolites. Cell. Mol. Life Sci. 2008; 65 (13): 2001–2018.Hardeland R. et al. Melatonin, hormone of darkness and more — occurrence, control mechanisms, actions, and bioactive metabolites. Cell. Mol. Life Sci. 2008; 65 (13): 2001–2018.Muller H. L., Handwerker G., Wollny B. et al. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J. Clin. Endocrinol. Metab. 2002; 87 (8): 3993–3996.Muller H. L., Handwerker G., Wollny B. et al. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J. Clin. Endocrinol. Metab. 2002; 87 (8): 3993–3996.Muller H. L., Handwerker G., Gebhardt U. et al. Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control. 2006; 17 (4): 583–589.Muller H. L., Handwerker G., Gebhardt U. et al. Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control. 2006; 17 (4): 583–589.Lin L., Faraco J., Li R. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999; 98 (3): 365–376.Lin L., Faraco J., Li R. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999; 98 (3): 365–376.Chemelli R. M., Willie J. T., Sinton C. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999; 98 (4): 437–451.Chemelli R. M., Willie J. T., Sinton C. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999; 98 (4): 437–451.Nishino S., Ripley B., Overeem S. et al. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000; 355 (9197): 39–40.Nishino S., Ripley B., Overeem S. et al. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000; 355 (9197): 39–40.Krahn L. E., Boeve B. F., Oliver L., Silber M. H. Hypocretin (orexin) and melatonin values in a narcoleptic- like sleep disorder after pinealectomy. Sleep Medicine. 2002; 3 (6): 521–523.Krahn L. E., Boeve B. F., Oliver L., Silber M. H. Hypocretin (orexin) and melatonin values in a narcoleptic- like sleep disorder after pinealectomy. Sleep Medicine. 2002; 3 (6): 521–523.Marcus C. L., Trescher W. H., Halbower A. C., Lutz J. Secondary narcolepsy in children with brain tumors. Sleep. 2002; 25 (4): 435–439.Marcus C. L., Trescher W. H., Halbower A. C., Lutz J. Secondary narcolepsy in children with brain tumors. Sleep. 2002; 25 (4): 435–439.Laakso M. L., Porkka-Heiskanen T., Alila A. et al. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J. Pineal. Res. 1990; 9: 39–50.Laakso M. L., Porkka-Heiskanen T., Alila A. et al. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J. Pineal. Res. 1990; 9: 39–50.Bloch K. E., Schoch O. D., Zhang J. N., Russi E. W. German version of the Epworth Sleepiness Scale. Respiration. 1999; 66: 440–447.Bloch K. E., Schoch O. D., Zhang J. N., Russi E. W. German version of the Epworth Sleepiness Scale. Respiration. 1999; 66: 440–447.

The authors declare that there are no conflicts of interest present.