vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v11i5.445vsp-444Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEПРИМЕНЕНИЕ ОСМОТИЧЕСКИХ СЛАБИТЕЛЬНЫХ В ЛЕЧЕНИИ ХРОНИЧЕСКИХ ЗАПОРОВ У ДЕТЕЙOSMOTIC LAXATIVES IN TREATMENT OF CHRONIC CONSTIPATIONS IN CHILDRENКорниенкоЕ. А.KornienkoE. A.elenkornienk@yandex.ruКомаровК. М.KomarovK. M.elenkornienk@yandex.ruТипикинаМ. Ю.TipikinaM. Yu.elenkornienk@yandex.ruЛободаТ. Б.LobodaT. B.elenkornienk@yandex.ruСанкт-Петербургский государственный педиатрический медицинский университетРоссияSt. Petersburg State Pediatric Medical UniversityRussian FederationДетская городская больница № 22, Санкт-ПетербурРоссияChildren Municipal Hospital № 22, St. PetersburgRussian FederationДетская городская клиническая больница № 5 им. Н.Ф. Филатова, Санкт-ПетербургРоссияN.F. Filatov Children Clinical Hospital № 5, St. PetersburgRussian Federation201219092012115Вопросы современной педиатрии152155Copyright © Корниенко Е.А., Комаров К.М., Типикина М.Ю., Лобода Т.Б., 20122012Корниенко Е.А., Комаров К.М., Типикина М.Ю., Лобода Т.Б.Kornienko E.A., Komarov K.M., Tipikina M.Y., Loboda T.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/444

Для оценки эффективности и безопасности осмотических слабительных полиэтиленгликоля с молекулярной массой 4000 кДа и лактулозы при хронических функциональных запорах у детей было проведено сравнительное исследование их эффективности у 80 человек в возрасте от 1 до 16 лет (46 детей принимали полиэтиленгликоль, 34 — лактулозу). Пациенты наблюдались на фоне лечения в течение 2 нед, проводилась клиническая и лабораторная оценка эффективности и безопасности терапии. На фоне лечения в обеих группах нормализация стула была достигнута в среднем на 3-и сут лечения, у большинства больных купированы боли и диспептические расстройства. Произошла нормализация консистенции стула. Изменений электролитного состава крови не наблюдалось. Каких-либо побочных эффектов препаратов не отмечено, но в первые дни приема лактулозы достоверно чаще регистрировали флатуленцию и урчание в животе, которые проходили самостоятельно при продолжении лечения. Лактулоза и полиэтиленгликоль 4000 продемонстрировали эффективность и безопасность в лечении хронических функциональных запоров у детей и могут быть рекомендованы к применению, в т.ч. в раннем возрасте.

A comparative trial including 80 patients at the age of 1–16 years old was performed in order to evaluate efficacy and safety of osmotic laxatives polyethylene glycol with molecular mass of 4000 kDa and lactulose (46 children received polyethylene glycol, 34 — lactulose) in children with chronic functional constipations. The observation period during the treatment lasted for 2 weeks, clinical and laboratory evaluation of the therapy efficacy and safety was carried out. The normalization of stool was achieved on the average in 3 days of treatment in both groups, pain and dyspepsia were arrested in the majority of the patients. Stool consistency was normalized. No side-effects were registered. However in the first days of lactulose treatment there were reliably more complaints on flatulence and rumbling, which passed spontaneously. Lactulose and polyethylene glycol were shown to be effective and safe in treatment of chronic functional constipations in children and can be recommended for usage even in infants.

Keywords: children, constipations, lactulose.

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The authors declare that there are no conflicts of interest present.