vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v11i4.363vsp-458Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ ЧЕЛОВЕЧЕСКИХ МОНОКЛОНАЛЬНЫХ АНТИТЕЛ К ФНО α У ДЕТЕЙ С ЮВЕНИЛЬНЫМ ИДИОПАТИЧЕСКИМ АРТРИТОМ ПРИ ПЕРВИЧНОЙ И ВТОРИЧНОЙ НЕЭФФЕКТИВНОСТИ ДРУГИХ ГЕННО-ИНЖЕНЕРНЫХ БИОЛОГИЧЕСКИХ ПРЕПАРАТОВEFFICACY AND SAFETY OF ANTI-TNFα HUMAN MONOCLONAL ANTIBODIES IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS AND SECONDARY RESISTANCE TO OTHER GENETICALLY ENGINEERED BIOLOGICAL AGENTSАлексееваЕ. И.AlexeevaE. I.

Алексеева Екатерина Иосифовна, доктор медицинских наук, профессор, заведующая ревматологическим отделением Научного центра здоровья детей РАМН, декан педиатрического факультета Первого МГМУ им. И.М. Сеченова

Yekaterina Alekseyeva, Doctor of Medical Science, professor, head of rheumatologic department of the Scientific Center of Children’s Health of the Russian Academy of Medical Science, dean of pediatric department of the I.M. Sechenov First Moscow State Medical University

alekatya@ya.ruБзароваТ. М.BzarovaT. M.alekatya@ya.ruВалиеваС. И.ValievaS. I.alekatya@ya.ruДенисоваР. В.DenisovaR. V.alekatya@ya.ruИсаеваК. Б.IsaevaK. B.alekatya@ya.ruЧомахидзеА. М.ChomakhidzeA. M.alekatya@ya.ruЧистяковаЕ. Г.ChistyakovaE. G.alekatya@ya.ruСлепцоваТ. В.SleptsovaT. V.alekatya@ya.ruМитенкоЕ. В.MitenkoE. V.alekatya@ya.ruТайбулатовН. И.TaibulatovN. I.alekatya@ya.ruНаучный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. Сеченова, МоскваРоссияScientific Centre of Children Health, RAMS, Moscow; I.M. Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Centre of Children Health, RAMS, MoscowRussian Federation201219072012114Вопросы современной педиатрии8288Copyright © Алексеева Е.И., Бзарова Т.М., Валиева С.И., Денисова Р.В., Исаева К.Б., Чомахидзе А.М., Чистякова Е.Г., Слепцова Т.В., Митенко Е.В., Тайбулатов Н.И., 20122012Алексеева Е.И., Бзарова Т.М., Валиева С.И., Денисова Р.В., Исаева К.Б., Чомахидзе А.М., Чистякова Е.Г., Слепцова Т.В., Митенко Е.В., Тайбулатов Н.И.Alexeeva E.I., Bzarova T.M., Valieva S.I., Denisova R.V., Isaeva K.B., Chomakhidze A.M., Chistyakova E.G., Sleptsova T.V., Mitenko E.V., Taibulatov N.I.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/458

Лечение ювенильного идиопатического артрита — одна из серьезных проблем детской ревматологии. В статье представлены результаты ретроспективного обсервационного исследования эффективности и безопасности адалимумаба (моноклональные человеческие антитела к фактору некроза опухоли α) в реальной клинической практике у пациентов с ювенильным идиопатическим артритом при первичной и вторичной неэффективности других генно-инженерных биологических препаратов: у 48 из 56 детей — инфликсимаба, у 2 — этанерцепта, у 5 — ритуксимаба, у 1 — абатацепта. Адалимумаб назначали подкожно, в дозе 40 мг, 1 раз в 2 нед. Эффективность оценивали по критериям АКРпеди. Через 4 нед лечения у 100% пациентов отмечено 30% улучшение, у 80% — 50%, у 60% — 70%. Через 24 нед лечения 30% улучшение зарегистрировано у 100% (56) детей, 50% — у 91% (51), 70% — у 74% (41) пациентов. Стадия неактивной болезни была зафиксирована через 24 нед у 55% детей, через год — у 85% пациентов; ремиссия достигнута у 55% больных. Тяжелых нежелательных явлений не отмечено. Полученные результаты демонстрируют, что адалимумаб эффективен у больных ювенильным идиопатическим артритом в случае первичной и вторичной резистентности к другим биологическим агентам.

 

 

Ключевые слова

Ключевые слова: дети, ювенильный идиопатический артрит, адалимумаб, лечение, блокаторы фактора некроза опухоли α, резистентность, генно-инженерные препараты.

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The authors declare that there are no conflicts of interest present.