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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15690/vsp.v11i1.131</article-id><article-id custom-type="elpub" pub-id-type="custom">vsp-509</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>МЕСТО ИБУПРОФЕНА В ТЕРАПИИ БОЛИ У ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>IBUPROFEN IN PAIN TREATMENT IN CHILDREN</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Р. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>R. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Денисова Рина Валериановна, кандидат медицинских наук, научный сотрудник ревматологического отделения НЦЗД РАМН</p><p>Адрес: 119991, Москва, Ломоносовский проспект, д. 2, тел.: (499) 134-14-94, e-mail: denisonarv@yandex.ru</p></bio><email xlink:type="simple">denisonarv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Scientific Centre of Children’s Health RAMS, Moscow</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>01</month><year>2012</year></pub-date><volume>11</volume><issue>1</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>46</fpage><lpage>50</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Денисова Р.В., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Денисова Р.В.</copyright-holder><copyright-holder xml:lang="en">Denisova R.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/509">https://vsp.spr-journal.ru/jour/article/view/509</self-uri><abstract/><trans-abstract xml:lang="en"/><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>боль</kwd><kwd>ибупрофен</kwd><kwd>лечение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>pain</kwd><kwd>ibuprofen</kwd><kwd>treatment</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Van Dijk A., McGrath P. A., Pickett W. et al. Pain prevalence in nine- to 13-year-old schoolchildren // Pain Res Manag. — 2006; 11: 234–240.</mixed-citation><mixed-citation xml:lang="en">Van Dijk A., McGrath P. A., Pickett W. et al. Pain prevalence in nine- to 13-year-old schoolchildren // Pain Res Manag. — 2006; 11: 234–240.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Perquin C. W., Hazebroek-Kampschreur A. A., Hunfeld J. A. et al. Pain in children and adolescents: a common experience // Pain. — 2000; 87: 51–58.</mixed-citation><mixed-citation xml:lang="en">Perquin C. W., Hazebroek-Kampschreur A. A., Hunfeld J. A. et al. Pain in children and adolescents: a common experience // Pain. — 2000; 87: 51–58.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Merlijn V. P., Hunfeld J. A., van der Wouden J. C. et al. Psychosocial factors associated with chronic pain in adolescents // Pain. — 2003; 101: 33–43.</mixed-citation><mixed-citation xml:lang="en">Merlijn V. P., Hunfeld J. A., van der Wouden J. C. et al. Psychosocial factors associated with chronic pain in adolescents // Pain. — 2003; 101: 33–43.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Slade G. D. Epidemiology of dental pain and dental caries among children and adolescents // Community Dent Health. — 2001; 18 (4): 219–227.</mixed-citation><mixed-citation xml:lang="en">Slade G. D. Epidemiology of dental pain and dental caries among children and adolescents // Community Dent Health. — 2001; 18 (4): 219–227.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">McGrath P. Chronic pain in children. In: Crombie I., Linton S., LeResche L., Von Korff M., editors. Epidemiology of Pain. — Seattle: IASP Press, 1999. — P. 81–102.</mixed-citation><mixed-citation xml:lang="en">McGrath P. Chronic pain in children. In: Crombie I., Linton S., LeResche L., Von Korff M., editors. Epidemiology of Pain. — Seattle: IASP Press, 1999. — P. 81–102.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Goes P. S., Watt R. G., Hardy R., Sheiham A. Impacts of dental pain on daily activities of adolescents aged 14–15 years and their families // Acta Odontol Scand. — 2008; 66 (1): 7–12.</mixed-citation><mixed-citation xml:lang="en">Goes P. S., Watt R. G., Hardy R., Sheiham A. Impacts of dental pain on daily activities of adolescents aged 14–15 years and their families // Acta Odontol Scand. — 2008; 66 (1): 7–12.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Walker S. M. Pain in children: recent advances and ongoing challenges // BJA. — 2008; 101 (1): 101–110.</mixed-citation><mixed-citation xml:lang="en">Walker S. M. Pain in children: recent advances and ongoing challenges // BJA. — 2008; 101 (1): 101–110.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lee B. O., Chaboyer W., Wallis M. Predictors of health-related quality of life 3 months after traumatic injury // J. Nurs. Scholarsh. — 2008; 40 (1): 83–90.</mixed-citation><mixed-citation xml:lang="en">Lee B. O., Chaboyer W., Wallis M. Predictors of health-related quality of life 3 months after traumatic injury // J. Nurs. Scholarsh. — 2008; 40 (1): 83–90.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vetter T. R. A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program // Anesth Analg. — 2008; 106 (3): 786–794.</mixed-citation><mixed-citation xml:lang="en">Vetter T. R. A clinical profile of a cohort of patients referred to an anesthesiology-based pediatric chronic pain medicine program // Anesth Analg. — 2008; 106 (3): 786–794.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lesko S. M., Mitchell A. A. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial // JAMA. — 1995; 273 (12): 929–933.</mixed-citation><mixed-citation xml:lang="en">Lesko S. M., Mitchell A. A. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial // JAMA. — 1995; 273 (12): 929–933.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Southey E. R., Soares-Weiser K., Kleijnen J. Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever // Curr. Med. Res. Opin. — 2009; 25 (9): 2207–2222.</mixed-citation><mixed-citation xml:lang="en">Southey E. R., Soares-Weiser K., Kleijnen J. Systematic review and meta-analysis of the clinical safety and tolerability of ibuprofen compared with paracetamol in paediatric pain and fever // Curr. Med. Res. Opin. — 2009; 25 (9): 2207–2222.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Perrott D. A., Piira T., Goodenough B., Champion G. D. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis // Arch. Pediatr. Adolesc. Med. — 2004; 158 (6): 521–526.</mixed-citation><mixed-citation xml:lang="en">Perrott D. A., Piira T., Goodenough B., Champion G. D. Efficacy and safety of acetaminophen vs ibuprofen for treating children's pain or fever: a meta-analysis // Arch. Pediatr. Adolesc. Med. — 2004; 158 (6): 521–526.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pierce C. A., Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review // Ann. Pharmacother. — 2010; 44 (3): 489–506.</mixed-citation><mixed-citation xml:lang="en">Pierce C. A., Voss B. Efficacy and safety of ibuprofen and acetaminophen in children and adults: a meta-analysis and qualitative review // Ann. Pharmacother. — 2010; 44 (3): 489–506.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Сайгитов Р. Т. Эффективность ибупрофена в терапии боли у детей: систематический обзор результатов рандомизирован- ных контролируемых исследований // Вопросы современной педиатрии. — 2010; 9 (6): 52–62.</mixed-citation><mixed-citation xml:lang="en">Сайгитов Р. Т. Эффективность ибупрофена в терапии боли у детей: систематический обзор результатов рандомизирован- ных контролируемых исследований // Вопросы современной педиатрии. — 2010; 9 (6): 52–62.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Moore P. A., Acs G., Hargreaves J. A. Postextraction pain relief in children: a clinical trial of liquid analgesics // Int. J. Clin. Pharmacol Ther Toxicol. — 1985; 23 (11): 573–577.</mixed-citation><mixed-citation xml:lang="en">Moore P. A., Acs G., Hargreaves J. A. Postextraction pain relief in children: a clinical trial of liquid analgesics // Int. J. Clin. Pharmacol Ther Toxicol. — 1985; 23 (11): 573–577.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">McGaw T., Raborn W., Grace M. Analgesics in pediatric dental surgery: relative efficacy of aluminum ibuprofen suspension and acetaminophen elixir // ASDC J. Dent. Child. — 1987; 54 (2): 106–109.</mixed-citation><mixed-citation xml:lang="en">McGaw T., Raborn W., Grace M. Analgesics in pediatric dental surgery: relative efficacy of aluminum ibuprofen suspension and acetaminophen elixir // ASDC J. Dent. Child. — 1987; 54 (2): 106–109.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Evers S., Rahmann A., Kraemer C. et al. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen // Neurology. — 2006; 67 (3): 497–499.</mixed-citation><mixed-citation xml:lang="en">Evers S., Rahmann A., Kraemer C. et al. Treatment of childhood migraine attacks with oral zolmitriptan and ibuprofen // Neurology. — 2006; 67 (3): 497–499.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Lewis D. W., Kellstein D., Burke B. et al. Children’s ibuprofen suspension for the acute treatment of pediatric migraine headache // Headache. — 2002; 42: 780–786.</mixed-citation><mixed-citation xml:lang="en">Lewis D. W., Kellstein D., Burke B. et al. Children’s ibuprofen suspension for the acute treatment of pediatric migraine headache // Headache. — 2002; 42: 780–786.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Hamalainen M. L., Hoppu K., Valkeila E. et al. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study // Neurology. — 1997; 48: 102–107.</mixed-citation><mixed-citation xml:lang="en">Hamalainen M. L., Hoppu K., Valkeila E. et al. Ibuprofen or acetaminophen for the acute treatment of migraine in children: a double-blind, randomized, placebo-controlled, crossover study // Neurology. — 1997; 48: 102–107.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Bertin L., Pons G., d'Athis P. et al. Randomized, double–blind, multicenler, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children // J. Pediatr. — 1991; 119 (5): 811–814.</mixed-citation><mixed-citation xml:lang="en">Bertin L., Pons G., d'Athis P. et al. Randomized, double–blind, multicenler, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children // J. Pediatr. — 1991; 119 (5): 811–814.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Schachtel B. P., Thoden W. R. A placebo-controlled model for assaying systemic analgesics in children // Clin. Pharmacol Ther. — 1993; 53 (5): 593–601.</mixed-citation><mixed-citation xml:lang="en">Schachtel B. P., Thoden W. R. A placebo-controlled model for assaying systemic analgesics in children // Clin. Pharmacol Ther. — 1993; 53 (5): 593–601.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Bertin L., Pons G., d'Athis P. et al. A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children // Fundam. Clin. Pharmacol. — 1996; 10 (4): 387–392.</mixed-citation><mixed-citation xml:lang="en">Bertin L., Pons G., d'Athis P. et al. A randomized, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children // Fundam. Clin. Pharmacol. — 1996; 10 (4): 387–392.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Shepherd M., Aickin R. Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures // Emerg. Med. Australas. — 2009; 21 (6): 484–490.</mixed-citation><mixed-citation xml:lang="en">Shepherd M., Aickin R. Paracetamol versus ibuprofen: a randomized controlled trial of outpatient analgesia efficacy for paediatric acute limb fractures // Emerg. Med. Australas. — 2009; 21 (6): 484–490.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Clark E., Plint A. C., Correll R. et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma // Pediatrics. — 2007; 119 (3): 460–467.</mixed-citation><mixed-citation xml:lang="en">Clark E., Plint A. C., Correll R. et al. A randomized, controlled trial of acetaminophen, ibuprofen, and codeine for acute pain relief in children with musculoskeletal trauma // Pediatrics. — 2007; 119 (3): 460–467.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Drendel A. L., Gorelick M. H., Weisman S. J. et al. A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain // Ann. Emerg. Med. — 2009; 54 (4): 553–560.</mixed-citation><mixed-citation xml:lang="en">Drendel A. L., Gorelick M. H., Weisman S. J. et al. A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain // Ann. Emerg. Med. — 2009; 54 (4): 553–560.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Friday J. H., Kanegaye J. T., McCaslin I. et al. Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial // Acad. Emerg. Med. — 2009; 16 (8): 711–716.</mixed-citation><mixed-citation xml:lang="en">Friday J. H., Kanegaye J. T., McCaslin I. et al. Ibuprofen provides analgesia equivalent to acetaminophen-codeine in the treatment of acute pain in children with extremity injuries: a randomized clinical trial // Acad. Emerg. Med. — 2009; 16 (8): 711–716.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Koller D. M., Myers A. B., Lorenz D., Godambe S. A. Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children // Pediatr Emerg. Care. — 2007; 23 (9): 627–633.</mixed-citation><mixed-citation xml:lang="en">Koller D. M., Myers A. B., Lorenz D., Godambe S. A. Effectiveness of oxycodone, ibuprofen, or the combination in the initial management of orthopedic injury-related pain in children // Pediatr Emerg. Care. — 2007; 23 (9): 627–633.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Silver S., Gano D., Gerretsen P. Acute treatment of paediatric migraine: a meta-analysis of efficacy // J. Paediatr. Child. Health. — 2008; 44 (1–2): 3–9.</mixed-citation><mixed-citation xml:lang="en">Silver S., Gano D., Gerretsen P. Acute treatment of paediatric migraine: a meta-analysis of efficacy // J. Paediatr. Child. Health. — 2008; 44 (1–2): 3–9.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Rabbie R., Derry S., Moore R. A., McQuay H. J. Ibuprofen with or without an antiemetic for acute migraine headaches in adults // Cochrane Database Syst. Rev. — 2010; 10: CD008039.</mixed-citation><mixed-citation xml:lang="en">Rabbie R., Derry S., Moore R. A., McQuay H. J. Ibuprofen with or without an antiemetic for acute migraine headaches in adults // Cochrane Database Syst. Rev. — 2010; 10: CD008039.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Gunner K. B., Smith H. D., Cromwell P. F., Yetman R. J. Practice guideline for diagnosis and management of migraine headaches in children and adolescents: Part One // J. Pediatr. Health. Care. — 2007; 21 (5): 327–332.</mixed-citation><mixed-citation xml:lang="en">Gunner K. B., Smith H. D., Cromwell P. F., Yetman R. J. Practice guideline for diagnosis and management of migraine headaches in children and adolescents: Part One // J. Pediatr. Health. Care. — 2007; 21 (5): 327–332.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Fuhlbrigge R. C., Chaiban R. The immune system, the skin, and childhood rheumatic disease // Curr. Rheumatol. Rep. — 2011; 13 (2): 103–109.</mixed-citation><mixed-citation xml:lang="en">Fuhlbrigge R. C., Chaiban R. The immune system, the skin, and childhood rheumatic disease // Curr. Rheumatol. Rep. — 2011; 13 (2): 103–109.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Dannecker G. E., Quartier P. Juvenile idiopathic arthritis: classification, clinical presentation and current treatments // Horm. Res. — 2009; 72 (1): 4–12.</mixed-citation><mixed-citation xml:lang="en">Dannecker G. E., Quartier P. Juvenile idiopathic arthritis: classification, clinical presentation and current treatments // Horm. Res. — 2009; 72 (1): 4–12.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Martini A., Lovell D. J. Juvenile idiopathic arthritis: state of the art and future perspective // Ann. Rheum. Dis. — 2010; 69 (7): 1260–1263.</mixed-citation><mixed-citation xml:lang="en">Martini A., Lovell D. J. Juvenile idiopathic arthritis: state of the art and future perspective // Ann. Rheum. Dis. — 2010; 69 (7): 1260–1263.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Rainsford K. D. Anti-inflammatory drugs in the 21st century // Subcell. Biochem. — 2007; 42: 3–27.</mixed-citation><mixed-citation xml:lang="en">Rainsford K. D. Anti-inflammatory drugs in the 21st century // Subcell. Biochem. — 2007; 42: 3–27.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Jacqz-Aigrain E., Anderson B. J. Pain control: non-steroidal antiinflammatory agents // Semin. Fetal. Neonatal Med. — 2006; 11 (4): 251–259.</mixed-citation><mixed-citation xml:lang="en">Jacqz-Aigrain E., Anderson B. J. Pain control: non-steroidal antiinflammatory agents // Semin. Fetal. Neonatal Med. — 2006; 11 (4): 251–259.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Steans A., Manners P. J., Robinson I. G. A multicentre, long-term eva luation of the safety and efficacy of ibuprofen syrup in children with juvenile chronic arthritis // Br. J. Clin. Pract. — 1990; 44 (5): 172–175.</mixed-citation><mixed-citation xml:lang="en">Steans A., Manners P. J., Robinson I. G. A multicentre, long-term eva luation of the safety and efficacy of ibuprofen syrup in children with juvenile chronic arthritis // Br. J. Clin. Pract. — 1990; 44 (5): 172–175.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Giannini E. H., Brewer E. J., Miller M. L. et al. Ibuprofen suspension in the treatment of juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group // J. Pediatr. — 1990; 117 (4): 645–652.</mixed-citation><mixed-citation xml:lang="en">Giannini E. H., Brewer E. J., Miller M. L. et al. Ibuprofen suspension in the treatment of juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group // J. Pediatr. — 1990; 117 (4): 645–652.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Goldenstein-Schainberg C., Yoshinari N. H. Drug treatment in juvenile chronic arthritis // Rev. Hosp. Clin. Fac. Med. Sao Paulo. — 1997; 52 (2): 90–95.</mixed-citation><mixed-citation xml:lang="en">Goldenstein-Schainberg C., Yoshinari N. H. Drug treatment in juvenile chronic arthritis // Rev. Hosp. Clin. Fac. Med. Sao Paulo. — 1997; 52 (2): 90–95.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hollingworth P. The use of non-steroidal anti-inflammatory drugs in paediatric rheumatic diseases // Br. J. Rheumatol. — 1993; 32 (1): 73–77.</mixed-citation><mixed-citation xml:lang="en">Hollingworth P. The use of non-steroidal anti-inflammatory drugs in paediatric rheumatic diseases // Br. J. Rheumatol. — 1993; 32 (1): 73–77.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Autret-Leca E. A general overview of the use of ibuprofen in paediatrics // Int. J. Clin. Pract. — 2003; 135: 9–12.</mixed-citation><mixed-citation xml:lang="en">Autret-Leca E. A general overview of the use of ibuprofen in paediatrics // Int. J. Clin. Pract. — 2003; 135: 9–12.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Van den Anker J. N. Use of ibuprofen in paediatric populations // J. R. Soc. Med. — 2007; 100: 18–22.</mixed-citation><mixed-citation xml:lang="en">Van den Anker J. N. Use of ibuprofen in paediatric populations // J. R. Soc. Med. — 2007; 100: 18–22.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Rainsford K. D. Ibuprofen: pharmacology, efficacy and safety // Inflammopharmacology. — 2009; 17 (6): 275–342.</mixed-citation><mixed-citation xml:lang="en">Rainsford K. D. Ibuprofen: pharmacology, efficacy and safety // Inflammopharmacology. — 2009; 17 (6): 275–342.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Flato B., Vinje O., Forre O. Toxicity of antirheumatic and antiinflam matory drugs in children // Clin. Rheumatol. — 1998; 17 (6): 505–510.</mixed-citation><mixed-citation xml:lang="en">Flato B., Vinje O., Forre O. Toxicity of antirheumatic and antiinflam matory drugs in children // Clin. Rheumatol. — 1998; 17 (6): 505–510.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Leroy S., Mosca A., Landre-Peigne C. et al. Ibuprofen in childhood: evidence-based review of efficacy and safety // Arch. Pediatr. — 2007; 14 (5): 477–484.</mixed-citation><mixed-citation xml:lang="en">Leroy S., Mosca A., Landre-Peigne C. et al. Ibuprofen in childhood: evidence-based review of efficacy and safety // Arch. Pediatr. — 2007; 14 (5): 477–484.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е. И., Литвицкий П. Ф. Ювенильный ревматоидный артрит. — М.: ВЕДИ, 2007. — 368 с.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е. И., Литвицкий П. Ф. Ювенильный ревматоидный артрит. — М.: ВЕДИ, 2007. — 368 с.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
