vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»vsp-557Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSОПЫТ ПРИМЕНЕНИЯ АБАТАЦЕПТА У БОЛЬНОЙ ЮВЕНИЛЬНЫМ РЕВМАТОИДНЫМ АРТРИТОМEXPERIENCE OF TREATMENT WITH ABATACEPT IN PATIENTS WITH JUVENILE RHEUMATOID ARTHRITISАлексееваЕ. И.AlekseyevaYe. I.

Контактная информация: Алексеева Екатерина Иосифовна, доктор медицинских наук, профессор, декан ФППО педиатрического факультета Первого МГМУ им. И.М. Сеченова, заведующая ревматологическим отделением Научного центра здоровья детей РАМН Адрес: 119991, Москва, Ломоносовский проспект, д. 2/62, тел.: (499) 134-02

neonatepearl@yandex.ruВалиеваС. И.ValiyevaS. I.neonatepearl@yandex.ruСлепцоваТ. В.SleptsovaT. V.neonatepearl@yandex.ruНаучный центр здоровья детей РАМН, Москва; Первый Московский государственный медицинский университет им. И.М. СеченоваРоссияScientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow; I.M. Sechenov First Moscow State Medical UniversityRussian FederationНаучный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowRussian Federation201117012011101Вопросы современной педиатрии160166Copyright © Алексеева Е.И., Валиева С.И., Слепцова Т.В., 20112011Алексеева Е.И., Валиева С.И., Слепцова Т.В.Alekseyeva Y.I., Valiyeva S.I., Sleptsova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/557

В статье представлен случай клинического наблюдения за больной ювенильным ревматоидным артритом, рефрактерным к терапии метотрексатом. На фоне комбинированной терапии метотрексатом и лефлуномидом у пациентки развились нежелательные явления, потребовавшие отмены лефлуномида. Описано успешное применение биологического агента ингибитора ко-стимуляции Т лимфоцитов — абатацепта. Его применение индуцировало ремиссию заболевания, что значительно повысило качество жизни пациентки и ее семьи.

The article presents a case report of a patient with juvenile rheumatoid arthritis refractory to the treatment with metothrexate. Combined therapy with metothrexate and leflunomide induced development of unfavorable effects resulted in cancellation of leflunomide. Successful administration of biological agent inhibitor of T-lymphocytes co-stimulation abatacept is described. Treatment with abatacept resulted in remission of a disease; it increased patient and her family’s quality of life.

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The authors declare that there are no conflicts of interest present.