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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-563</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Роль пневмококковой инфекции в развитии обострений у детей с бронхиальной астмой и обструктивным бронхитом</article-title><trans-title-group xml:lang="en"><trans-title>The role of pneumococcal infection in development of exacerbations in children with bronchial asthma and obstructive bronchitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кухтинова</surname><given-names>Н.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukhtinova</surname><given-names>N.V.</given-names></name></name-alternatives><email xlink:type="simple">natalya_kuhtinov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гавалов</surname><given-names>С.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavalov</surname><given-names>S.M.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кротов</surname><given-names>С.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krotov</surname><given-names>S.A.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кротова</surname><given-names>В.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Krotova</surname><given-names>V.A.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Новосибирский государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Novosibirsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЗАО «Вектор-Бэст», Новосибирск</institution></aff><aff xml:lang="en"><institution>CC Vector-Best, Novosibirsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>16</day><month>03</month><year>2011</year></pub-date><volume>10</volume><issue>2</issue><issue-title>Вопросы современной педиатрии</issue-title><fpage>22</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кухтинова Н., Гавалов С., Кротов С., Кротова В., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Кухтинова Н., Гавалов С., Кротов С., Кротова В.</copyright-holder><copyright-holder xml:lang="en">Kukhtinova N., Gavalov S., Krotov S., Krotova V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/563">https://vsp.spr-journal.ru/jour/article/view/563</self-uri><abstract/><trans-abstract xml:lang="en"><p>Pneumococcal infection remains the key cause of severe diseases of lower airways and deaths in children. The objective: to study the role of pneumococcal infection in pathogenesis of exacerbations of recurrent obstructive pulmonary diseases. Methods: etiological structure of lower airways infections was evaluated in 125 patients 1–15 years old with bronchial asthma or recurrent bronchitis. Results: etiologic role of Streptococcus pneumoniae in development of low airways infections was detected in 48% of patients with atopic asthma, 85% — with asthma without atopy, 97% — with recurrent bronchitis. Repeated microbiological examination confirmed chronic carriage of S. рneumoniae in nasopharinx in 31% of patients. Conclusion: early active prophylaxis with vaccine against pneumococcal infection including conjugated vaccines is able to prevent further progression of a disease.</p><p>Key words: children, bronchial asthma, obstructive bronchitis, exacerbation, pneumococcal infection.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">1.O’Brien K.L., Wolfson L.I., Henkle E. et al. Burden of diseases caused by Streptococcus pneumoniae in children global estimates. Lancet. 2009; 374: 983–902.</mixed-citation><mixed-citation xml:lang="en">1.O’Brien K.L., Wolfson L.I., Henkle E. et al. Burden of diseases caused by Streptococcus pneumoniae in children global estimates. Lancet. 2009; 374: 983–902.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sliman K.L., Daniels L., Garediner M. 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