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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-608</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эффективность и безопасность тоцилизумаба у больных тяжелым системным ювенильным идиопатическим артритом</article-title><trans-title-group xml:lang="en"><trans-title>TOCILIZUMAB EFFICACY AND SAFETY IN PATIENTS WITH SEVERE SYSTEMIC JUVENILE IDIOPATHIC ARTHRITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexeeva</surname><given-names>E.I.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Р.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>R.V.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Валиева</surname><given-names>С.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Valieva</surname><given-names>S.I.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бзарова</surname><given-names>Т.М.</given-names></name><name name-style="western" xml:lang="en"><surname>Bzarova</surname><given-names>T.M.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаева</surname><given-names>К.Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Isaeva</surname><given-names>K.B.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чистякова</surname><given-names>Е.Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chistyakova</surname><given-names>E.G.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Слепцова</surname><given-names>Т.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sleptsova</surname><given-names>T.V.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митенко</surname><given-names>Е.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mitenko</surname><given-names>E.V.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow&#13;
I.M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow&#13;
I.M. Sechenov First Moscow State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2011</year></pub-date><volume>10</volume><issue>3</issue><issue-title>Вопросы современной педиатрии</issue-title><elocation-id>24–32</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Алексеева Е., Денисова Р., Валиева С., Бзарова Т., Исаева К., Чистякова Е., Слепцова Т., Митенко Е., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Алексеева Е., Денисова Р., Валиева С., Бзарова Т., Исаева К., Чистякова Е., Слепцова Т., Митенко Е.</copyright-holder><copyright-holder xml:lang="en">Alexeeva E., Denisova R., Valieva S., Bzarova T., Isaeva K., Chistyakova E., Sleptsova T., Mitenko E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/608">https://vsp.spr-journal.ru/jour/article/view/608</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cassidy J.T., Petty R.E. Juvenile idiopathic arthritis. In: Textbook of pediatric rheumatology. Eds. Cassidy J.T., Petty R.E. 5th ed. Philadelphia: WB Saunders. 2005.</mixed-citation><mixed-citation xml:lang="en">Cassidy J.T., Petty R.E. Juvenile idiopathic arthritis. In: Textbook of pediatric rheumatology. Eds. Cassidy J.T., Petty R.E. 5th ed. Philadelphia: WB Saunders. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Валиева С.И., Бзарова Т.М.. Эффективность и безопасность повторных курсов лечения ритуксимабом тяжелого рефрактерного ювенильного ревматоидного артрита. Вопросы современной педиатрии. 2009; 8(5):14–25.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Валиева С.И., Бзарова Т.М.. Эффективность и безопасность повторных курсов лечения ритуксимабом тяжелого рефрактерного ювенильного ревматоидного артрита. Вопросы современной педиатрии. 2009; 8(5):14–25.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е. И., Литвицкий П. Ф. Руководство для врачей. Под общей ред. А.А. Баранова. М. 2007. 368 с.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е. И., Литвицкий П. Ф. Руководство для врачей. Под общей ред. А.А. Баранова. М. 2007. 368 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Veldhuis G.J., Willemse PH.B., Sleijfer D.T. et al. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non–small cell lung cancer. J. Clin. Oncol. 1995; 13: 2585–2593.</mixed-citation><mixed-citation xml:lang="en">Veldhuis G.J., Willemse PH.B., Sleijfer D.T. et al. Toxicity and efficacy of escalating dosages of recombinant human interleukin-6 after chemotherapy in patients with breast cancer or non–small cell lung cancer. J. Clin. Oncol. 1995; 13: 2585–2593.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Rothwell N.J., Busbridge N.J., Lefeuvre R.A. et al. Interleukin–6 is a centrally acting endogenous pyrogen in the rat. Can. J. Physiol. Pharmacol. 1991; 69: 1465–1469.</mixed-citation><mixed-citation xml:lang="en">Rothwell N.J., Busbridge N.J., Lefeuvre R.A. et al. Interleukin–6 is a centrally acting endogenous pyrogen in the rat. Can. J. Physiol. Pharmacol. 1991; 69: 1465–1469.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Castell J.V., Gomez-Lechon M.J., David M. et al. Recombinant human interleukin–6 (IL–6/BSF–2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett. 1988; 232: 347–350.</mixed-citation><mixed-citation xml:lang="en">Castell J.V., Gomez-Lechon M.J., David M. et al. Recombinant human interleukin–6 (IL–6/BSF–2/HSF) regulates the synthesis of acute phase proteins in human hepatocytes. FEBS Lett. 1988; 232: 347–350.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Nemeth E., Rivera S., Gabayan V. et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 2004; 113: 1271–1276.</mixed-citation><mixed-citation xml:lang="en">Nemeth E., Rivera S., Gabayan V. et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 2004; 113: 1271–1276.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ikebuchi K., Wong G.G., Clark S.C. et al. Interleukin–6 enhancement of interleukin–3 dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA. 1987; 84: 9035–9039.</mixed-citation><mixed-citation xml:lang="en">Ikebuchi K., Wong G.G., Clark S.C. et al. Interleukin–6 enhancement of interleukin–3 dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci. USA. 1987; 84: 9035–9039.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura H., Ishibashi T., Uchida T. et al. Interleukin 6 is a differentiation factor for human megakaryocytes in vitro. Eur. J. Immunol. 1990; 20: 1927–1931.</mixed-citation><mixed-citation xml:lang="en">Kimura H., Ishibashi T., Uchida T. et al. Interleukin 6 is a differentiation factor for human megakaryocytes in vitro. Eur. J. Immunol. 1990; 20: 1927–1931.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Tsigos C., Papankolaou D.A., Defensor R. et al. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrinology. 1997; 66: 54–62.</mixed-citation><mixed-citation xml:lang="en">Tsigos C., Papankolaou D.A., Defensor R. et al. Dose effects of recombinant human interleukin-6 on pituitary hormone secretion and energy expenditure. Neuroendocrinology. 1997; 66: 54–62.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Heliovaara M.K., Teppo A.M., Karonen S.L. et al. Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute phase proteins associate with glucose and lipid metabolism in healthy subjects. Diabetes Obes. Metab. 2005; 7: 729–736.</mixed-citation><mixed-citation xml:lang="en">Heliovaara M.K., Teppo A.M., Karonen S.L. et al. Plasma IL-6 concentration is inversely related to insulin sensitivity, and acute phase proteins associate with glucose and lipid metabolism in healthy subjects. Diabetes Obes. Metab. 2005; 7: 729–736.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cutolo M., Straub R.H. Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction. Autoimmun. Rev. 2008; 7: 223–228.</mixed-citation><mixed-citation xml:lang="en">Cutolo M., Straub R.H. Circadian rhythms in arthritis: hormonal effects on the immune/inflammatory reaction. Autoimmun. Rev. 2008; 7: 223–228.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nishimoto N. Kishimoto T. Humanized antihuman IL-6 receptor antibody, tocilizumab. Handb. Exp. Pharmacol. 2008; 181: 151–160.</mixed-citation><mixed-citation xml:lang="en">Nishimoto N. Kishimoto T. Humanized antihuman IL-6 receptor antibody, tocilizumab. Handb. Exp. Pharmacol. 2008; 181: 151–160.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">European Medicines Agency. Ro Actemra (tocilizumab): summary of product characteristics. URL: http://www.emea.europa.eu/humandoes/PDFs/EPAR/RoActemra/H-955-PI-en.pdf [accessed 2009 Mar 23].</mixed-citation><mixed-citation xml:lang="en">European Medicines Agency. Ro Actemra (tocilizumab): summary of product characteristics. URL: http://www.emea.europa.eu/humandoes/PDFs/EPAR/RoActemra/H-955-PI-en.pdf [accessed 2009 Mar 23].</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Chugai Pharmactutical Co. Actemra, a humanized antihuman IL–6 receptor monoclonal antibody obtained approval for indications of rheumatoid arthritis, polyarticular course juvenile idiopathic arthritis and systemic onset juvenile idiopathic arthritis [media release]. Available from URL: http://www.chugai-pharm.co.jp [accessed 2008 Sep 24].</mixed-citation><mixed-citation xml:lang="en">Chugai Pharmactutical Co. Actemra, a humanized antihuman IL–6 receptor monoclonal antibody obtained approval for indications of rheumatoid arthritis, polyarticular course juvenile idiopathic arthritis and systemic onset juvenile idiopathic arthritis [media release]. Available from URL: http://www.chugai-pharm.co.jp [accessed 2008 Sep 24].</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Imagawa T., Ozawa R., Miyamae T. et al. Efficacy and safety in 48-week treatment of tocilizumab in children with polyarticular course JIA with polyarticular or olygoarticular onset. Ann. Rheum. Dis. 2007; 66 (Suppl. II): 550.</mixed-citation><mixed-citation xml:lang="en">Imagawa T., Ozawa R., Miyamae T. et al. Efficacy and safety in 48-week treatment of tocilizumab in children with polyarticular course JIA with polyarticular or olygoarticular onset. Ann. Rheum. Dis. 2007; 66 (Suppl. II): 550.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Yokota S., Imagawa T., Miyamae T. Safety and efficacy of up to three years of continuous tocilizumab therapy in children with systemic onset juvenile idiopathic arthritis [SAT0536]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 715.</mixed-citation><mixed-citation xml:lang="en">Yokota S., Imagawa T., Miyamae T. Safety and efficacy of up to three years of continuous tocilizumab therapy in children with systemic onset juvenile idiopathic arthritis [SAT0536]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 715.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Inaba Y., Aoki C., Ozawa R. Radiologic evaluation of large joints during tocilizumab treatment in children with systemic juvenile idiopathic arthritis [SAT0555]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 720.</mixed-citation><mixed-citation xml:lang="en">Inaba Y., Aoki C., Ozawa R. Radiologic evaluation of large joints during tocilizumab treatment in children with systemic juvenile idiopathic arthritis [SAT0555]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 720.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Yokota S., Imagawa T., Mori M. et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomized, double-blind, placebo-controlled, withdrawal phase III trial. Lancet. 2008; 371: 998–1006.</mixed-citation><mixed-citation xml:lang="en">Yokota S., Imagawa T., Mori M. et al. Efficacy and safety of tocilizumab in patients with systemic-onset juvenile idiopathic arthritis: a randomized, double-blind, placebo-controlled, withdrawal phase III trial. Lancet. 2008; 371: 998–1006.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Yokota S., Miyamae T., Imagawa T. et al. Therapeutic efficacy of humanized recombinant anti–interleukin–6 receptor antibody in children with systemic onset juvenile idiopathic arthritis. Arthritis Rheum. 2005; 52: 818-825.</mixed-citation><mixed-citation xml:lang="en">Yokota S., Miyamae T., Imagawa T. et al. Therapeutic efficacy of humanized recombinant anti–interleukin–6 receptor antibody in children with systemic onset juvenile idiopathic arthritis. Arthritis Rheum. 2005; 52: 818-825.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Aoki C., Inaba Y., Ozawa R. Effects of tocilizumab on radiological findings in polyarticular juvenile idiopathic arthritis [OP-0145]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 118.</mixed-citation><mixed-citation xml:lang="en">Aoki C., Inaba Y., Ozawa R. Effects of tocilizumab on radiological findings in polyarticular juvenile idiopathic arthritis [OP-0145]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 118.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Quartier P., Maire D., Souabni L. Efficacy and safety of tocilizumab in systemic onset juvenile idiopathic arthritis in french centers [FRI0462]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 506.</mixed-citation><mixed-citation xml:lang="en">Quartier P., Maire D., Souabni L. Efficacy and safety of tocilizumab in systemic onset juvenile idiopathic arthritis in french centers [FRI0462]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 506.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kaneko U., Imagawa T., Kishi T. Discrepancy between progression of joint damage and improvement of systemic inflammation in patients with systemic-onset juvenile idiopathic arthritis treated with tocilizumab [SAT0548]. Ann. Rheum. Dis. 2009; 68 (Suppl.3): 719.</mixed-citation><mixed-citation xml:lang="en">Kaneko U., Imagawa T., Kishi T. Discrepancy between progression of joint damage and improvement of systemic inflammation in patients with systemic-onset juvenile idiopathic arthritis treated with tocilizumab [SAT0548]. Ann. Rheum. Dis. 2009; 68 (Suppl.3): 719.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Giannini E.H., Ruperto N., Ravelli A. et al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum. 1997; 40: 1202–1209.</mixed-citation><mixed-citation xml:lang="en">Giannini E.H., Ruperto N., Ravelli A. et al. Preliminary definition of improvement in juvenile arthritis. Arthritis Rheum. 1997; 40: 1202–1209.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yokota S., Imagawa T., Miyamae T. Safety and efficacy of up to three years of continuous tocilizumab therapy in children with systemic-onset juvenile idiopathic arthritis [SAT0536]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 715.</mixed-citation><mixed-citation xml:lang="en">Yokota S., Imagawa T., Miyamae T. Safety and efficacy of up to three years of continuous tocilizumab therapy in children with systemic-onset juvenile idiopathic arthritis [SAT0536]. Ann. Rheum. Dis. 2009; 68 (Suppl. 3): 715.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
