<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-629</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Человеческие моноклональные антитела к ФНО : новые возможности в лечении ювенильного идиопатического артрита</article-title><trans-title-group xml:lang="en"><trans-title>HUMAN MONOCLONAL ANTIBODIES TO TNF: NEW OPPORTUNITIES IN TREATMENT OF JUVENILE IDIOPATHIC SPONDYLITIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Денисова</surname><given-names>Р.В.</given-names></name><name name-style="western" xml:lang="en"><surname>Denisova</surname><given-names>R.V.</given-names></name></name-alternatives><email xlink:type="simple">denisovarv@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексеева</surname><given-names>Е.И.</given-names></name><name name-style="western" xml:lang="en"><surname>Alekseeva</surname><given-names>E.I.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва</aff><aff xml:lang="en">Sсientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">Научный центр здоровья детей РАМН, Москва&#13;
Первый Московский государственный медицинский университет им. И.М. Сеченова</aff><aff xml:lang="en">Sсientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow&#13;
I.M. Sechenov First Moscow State Medical University</aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>16</day><month>05</month><year>2011</year></pub-date><volume>10</volume><issue>3</issue><issue-title>Вопросы современной педиатрии</issue-title><elocation-id>150–156</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Денисова Р., Алексеева Е., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Денисова Р., Алексеева Е.</copyright-holder><copyright-holder xml:lang="en">Denisova R., Alekseeva E.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/629">https://vsp.spr-journal.ru/jour/article/view/629</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cassidy J., Petty R. Texbook of paediatric rheumatology. 5 еd. Philadelphia: Elsevier Saunders. 2005.</mixed-citation><mixed-citation xml:lang="en">Cassidy J., Petty R. Texbook of paediatric rheumatology. 5 еd. Philadelphia: Elsevier Saunders. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Григорьева А.А., Денисова Р.В. Причины развития резистентности к ингибиторам ФНО α и пути ее преодоления. Вопросы современной педиатрии. 2009; 8 (6): 42–47.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Григорьева А.А., Денисова Р.В. Причины развития резистентности к ингибиторам ФНО α и пути ее преодоления. Вопросы современной педиатрии. 2009; 8 (6): 42–47.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Алексеева Е.И., Лисицин А.О., Карагулян Н.А. Адалимумаб: новые возможности лечения ювенильных артритов. Вопросы современной педиатрии. 2009; 8 (3): 88–94.</mixed-citation><mixed-citation xml:lang="en">Алексеева Е.И., Лисицин А.О., Карагулян Н.А. Адалимумаб: новые возможности лечения ювенильных артритов. Вопросы современной педиатрии. 2009; 8 (3): 88–94.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D., Kivitz A., Schiff M.H. et al. Efficacy and safety of adalimumab in patients with ankylosing spondylitis. Arthritis Rheum. 2006; 54 (7): 2136–2146.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D., Kivitz A., Schiff M.H. et al. Efficacy and safety of adalimumab in patients with ankylosing spondylitis. Arthritis Rheum. 2006; 54 (7): 2136–2146.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Davis J.C., Revicki D., van der Heijde D.M. et al. Health-related quality of life outcomes in patients with active ankylosing spondylitis treated with adalimumab: results from a randomized controlled study. Arthritis Rheum. 2007; 57: 1050–1057.</mixed-citation><mixed-citation xml:lang="en">Davis J.C., Revicki D., van der Heijde D.M. et al. Health-related quality of life outcomes in patients with active ankylosing spondylitis treated with adalimumab: results from a randomized controlled study. Arthritis Rheum. 2007; 57: 1050–1057.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Revicki D.A., Luo M.P. et al. Adalimumab reduces pain, fatigue, and stiffness in patients with ankylosing spondylitis: results from the adalimumab trial evaluating long-term safety and efficacy for ankylosing spondylitis (ATLAS). J. Rheumatol. 2008; 35 (7): 1346–1353.</mixed-citation><mixed-citation xml:lang="en">Revicki D.A., Luo M.P. et al. Adalimumab reduces pain, fatigue, and stiffness in patients with ankylosing spondylitis: results from the adalimumab trial evaluating long-term safety and efficacy for ankylosing spondylitis (ATLAS). J. Rheumatol. 2008; 35 (7): 1346–1353.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D., Schiff M.H., Sieper J. et al. Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial. Ann. Rheum. Dis. 2009; 68 (6): 922–929.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D., Schiff M.H., Sieper J. et al. Adalimumab effectiveness for the treatment of ankylosing spondylitis is maintained for up to 2 years: long-term results from the ATLAS trial. Ann. Rheum. Dis. 2009; 68 (6): 922–929.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Lambert R.G., Salonen D. et al. Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2007; 56 (12): 4005–4014.</mixed-citation><mixed-citation xml:lang="en">Lambert R.G., Salonen D. et al. Adalimumab significantly reduces both spinal and sacroiliac joint inflammation in patients with ankylosing spondylitis: a multicenter, randomized, double-blind, placebo-controlled study. Arthritis Rheum. 2007; 56 (12): 4005–4014.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D., Pangan A.L., Schiff M.H. Adalimumab effectively reduces the signs and symptoms of active ankylosing spondylitis in patients with total spinal ankylosis. Ann. Rheum. Dis. 2008; 67 (9): 1218–1221.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D., Pangan A.L., Schiff M.H. Adalimumab effectively reduces the signs and symptoms of active ankylosing spondylitis in patients with total spinal ankylosis. Ann. Rheum. Dis. 2008; 67 (9): 1218–1221.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Rudwaleit M., Claudepierre P., Kron M. et al. Effectiveness of adalimumab in treating patients with ankylosing spondylitis associated with enthesitis and peripheral arthritis. Arthritis Res. Ther. 2010; 12 (2): 43.</mixed-citation><mixed-citation xml:lang="en">Rudwaleit M., Claudepierre P., Kron M. et al. Effectiveness of adalimumab in treating patients with ankylosing spondylitis associated with enthesitis and peripheral arthritis. Arthritis Res. Ther. 2010; 12 (2): 43.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D., Salonen D., Weissman B.N., Landewé R. et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res. Ther. 2009; 11 (4): 127.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D., Salonen D., Weissman B.N., Landewé R. et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res. Ther. 2009; 11 (4): 127.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Van der Heijde D.M., Revicki D.A. et al. Physical function, disease activity, and health-related quality of life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis. Arthritis Res. Ther. 2009; 11 (4): 124.</mixed-citation><mixed-citation xml:lang="en">Van der Heijde D.M., Revicki D.A. et al. Physical function, disease activity, and health-related quality of life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis. Arthritis Res. Ther. 2009; 11 (4): 124.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Rudwaleit M., Claudepierre P.J. et al. Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis. Rheumatol. 2009; 36 (4): 801–808.</mixed-citation><mixed-citation xml:lang="en">Rudwaleit M., Claudepierre P.J. et al. Effectiveness, safety, and predictors of good clinical response in 1250 patients treated with adalimumab for active ankylosing spondylitis. Rheumatol. 2009; 36 (4): 801–808.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Rudwaleit M., Olivieri I., Boki K.A. Adalimumab is effective and well tolerated in treating patients with ankylosing spondylitis who have advanced spinal fusion. Rheumatology (Oxford). 2009; 48 (5): 551–557.</mixed-citation><mixed-citation xml:lang="en">Rudwaleit M., Olivieri I., Boki K.A. Adalimumab is effective and well tolerated in treating patients with ankylosing spondylitis who have advanced spinal fusion. Rheumatology (Oxford). 2009; 48 (5): 551–557.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sulpice M., Deslandre C.J., Quartier P. Efficacy and safety of TNF alpha antagonist therapy in patients with juvenile spondyloarthropathies. Joint Bone Spine. 2009; 76 (1): 24–27.</mixed-citation><mixed-citation xml:lang="en">Sulpice M., Deslandre C.J., Quartier P. Efficacy and safety of TNF alpha antagonist therapy in patients with juvenile spondyloarthropathies. Joint Bone Spine. 2009; 76 (1): 24–27.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
