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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">vsp</journal-id><journal-title-group><journal-title xml:lang="ru">Вопросы современной педиатрии</journal-title><trans-title-group xml:lang="en"><trans-title>Current Pediatrics</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1682-5527</issn><issn pub-type="epub">1682-5535</issn><publisher><publisher-name>Издательство «ПедиатрЪ»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">vsp-640</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LITERATURE REVIEW</subject></subj-group></article-categories><title-group><article-title>Целиакия у детей: решенные  и нерешенные вопросы этиопатогенез</article-title><trans-title-group xml:lang="en"><trans-title>CELIAC DISEASE IN CHILDREN: SOLVED AND UNSOLVED QUESTIONS OF AETIOPATHOGENESIS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Захарова</surname><given-names>И.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zakharova</surname><given-names>I.N.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Боровик</surname><given-names>Т.Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Borovik</surname><given-names>Т.E.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рославцева</surname><given-names>Е.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Roslavtseva</surname><given-names>Е.А.</given-names></name></name-alternatives><email xlink:type="simple">roslikea@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андрюхина</surname><given-names>Е.Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Andrukhina</surname><given-names>Е.N.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дмитриева</surname><given-names>Ю.А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dmitrieva</surname><given-names>Yu.А.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзебисова</surname><given-names>Ф.С.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzebisova</surname><given-names>F.S.</given-names></name></name-alternatives><email xlink:type="simple">neonatepearl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российская медицинская академия последипломного образования, Москва</institution></aff><aff xml:lang="en"><institution>Russian medical academy of postgraduate education, Moscow</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научный центр здоровья детей РАМН, Москва</institution></aff><aff xml:lang="en"><institution>Scientific Center of Children’s Health, Russian Academy of Medical Sciences, Moscow</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>16</day><month>07</month><year>2011</year></pub-date><volume>10</volume><issue>4</issue><issue-title>Вопросы современной педиатрии</issue-title><elocation-id>30–35</elocation-id><permissions><copyright-statement>Copyright &amp;#x00A9; Захарова И., Боровик Т., Рославцева Е., Андрюхина Е., Дмитриева Ю., Дзебисова Ф., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Захарова И., Боровик Т., Рославцева Е., Андрюхина Е., Дмитриева Ю., Дзебисова Ф.</copyright-holder><copyright-holder xml:lang="en">Zakharova I., Borovik Т., Roslavtseva Е., Andrukhina Е., Dmitrieva Y., Dzebisova F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://vsp.spr-journal.ru/jour/article/view/640">https://vsp.spr-journal.ru/jour/article/view/640</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dowd B., Walker-Smith J., Gee S. Arateus and the coeliac affection. Brit. Med. J. 1974; 2: 445–447.</mixed-citation><mixed-citation xml:lang="en">Dowd B., Walker-Smith J., Gee S. Arateus and the coeliac affection. Brit. Med. J. 1974; 2: 445–447.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cluysenaer O.J.J., van Tongeren J.H.M. Malabsorptionin coeliac sprue. The Hague. Martinus Nijhoff Medical Division. 1977. Р. 1–4.</mixed-citation><mixed-citation xml:lang="en">Cluysenaer O.J.J., van Tongeren J.H.M. Malabsorptionin coeliac sprue. The Hague. Martinus Nijhoff Medical Division. 1977. Р. 1–4.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Gee S. On the coeliac affection. St. Bartholomew’s Hospital Report. 1888; 24: 17–20.</mixed-citation><mixed-citation xml:lang="en">Gee S. On the coeliac affection. St. Bartholomew’s Hospital Report. 1888; 24: 17–20.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Di Sant–Agnese P.A., Darling R., Perera G., Shea E. Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics. 1953; 12: 549–551.</mixed-citation><mixed-citation xml:lang="en">Di Sant–Agnese P.A., Darling R., Perera G., Shea E. Abnormal electrolyte composition of sweat in cystic fibrosis of the pancreas. Pediatrics. 1953; 12: 549–551.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Dicke W.K. Coeliakie. Een onderzoek naar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. MD Thesis. Utrecht. 1950.</mixed-citation><mixed-citation xml:lang="en">Dicke W.K. Coeliakie. Een onderzoek naar de nadelige invloed van sommige graansoorten op de lijder aan coeliakie. MD Thesis. Utrecht. 1950.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Paulley J.W. Observations on the aetiology of idiopathic steatorrhoea. Jejunal and lymph-node biopsies. Br. Med. J. 1954; 4: 1318–1321.</mixed-citation><mixed-citation xml:lang="en">Paulley J.W. Observations on the aetiology of idiopathic steatorrhoea. Jejunal and lymph-node biopsies. Br. Med. J. 1954; 4: 1318–1321.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Dieterich W., Ehnis T., Bauer M. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat. Med. 1997; 3: 725–726.</mixed-citation><mixed-citation xml:lang="en">Dieterich W., Ehnis T., Bauer M. et al. Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat. Med. 1997; 3: 725–726.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Shan L., Molberg O., Parrot I. et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002; 297: 2275–2279.</mixed-citation><mixed-citation xml:lang="en">Shan L., Molberg O., Parrot I. et al. Structural basis for gluten intolerance in celiac sprue. Science. 2002; 297: 2275–2279.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dubé C., Rostom A., Sy R. еt al. The prevalence of celiac disease in average risk and at risk Western European populations: a systematic review. Gastroenterology. 2005; 128: 57–67.</mixed-citation><mixed-citation xml:lang="en">Dubé C., Rostom A., Sy R. еt al. The prevalence of celiac disease in average risk and at risk Western European populations: a systematic review. Gastroenterology. 2005; 128: 57–67.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Greco L., Romino R., Coto I. et al. The first large population based twin study of coeliac disease. Gut. 2002; 50: 624–628.</mixed-citation><mixed-citation xml:lang="en">Greco L., Romino R., Coto I. et al. The first large population based twin study of coeliac disease. Gut. 2002; 50: 624–628.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Nistico L., Fagnani C., Coto I. et al. Concordance, disease progression, and heritability of coeliac disease in Italian twins. Gut. 2006; 55: 803–808.</mixed-citation><mixed-citation xml:lang="en">Nistico L., Fagnani C., Coto I. et al. Concordance, disease progression, and heritability of coeliac disease in Italian twins. Gut. 2006; 55: 803–808.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Tollefsen S., Arentz-Hansen H., Fleckenstein B. et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J. Clin. Invest. 2006; 116 (8): 2226–2236.</mixed-citation><mixed-citation xml:lang="en">Tollefsen S., Arentz-Hansen H., Fleckenstein B. et al. HLA-DQ2 and -DQ8 signatures of gluten T cell epitopes in celiac disease. J. Clin. Invest. 2006; 116 (8): 2226–2236.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Sollid L.M. Molecular basis of celiac disease. Ann Rev. Immunol. 2000; 18: 53–81.</mixed-citation><mixed-citation xml:lang="en">Sollid L.M. Molecular basis of celiac disease. Ann Rev. Immunol. 2000; 18: 53–81.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Karell K., Louka A.S., Moodie S.J. et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum. Immunol. 2003; 64: 469–477.</mixed-citation><mixed-citation xml:lang="en">Karell K., Louka A.S., Moodie S.J. et al. HLA types in celiac disease patients not carrying the DQA1*05-DQB1*02 (DQ2) heterodimer: results from the European Genetics Cluster on Celiac Disease. Hum. Immunol. 2003; 64: 469–477.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Korponay–Szabo I.R. Pathogenesis of coeliac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009; 10: 8–10.</mixed-citation><mixed-citation xml:lang="en">Korponay–Szabo I.R. Pathogenesis of coeliac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009; 10: 8–10.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Wolters V.M., Wijmenga C. Genetic Background of Celiac Disease and Its Clinical Implications. Am. J. Gastroenterol. 2008; 103 (1): 190–195.</mixed-citation><mixed-citation xml:lang="en">Wolters V.M., Wijmenga C. Genetic Background of Celiac Disease and Its Clinical Implications. Am. J. Gastroenterol. 2008; 103 (1): 190–195.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Пухликова Т.В., Лебедева Л.Л., Потапова Т.Н. и др. Значение генетических факторов в развитии целиакии. Вопросы современной педиатрии. 2010; 9 (4): 40–43.</mixed-citation><mixed-citation xml:lang="en">Пухликова Т.В., Лебедева Л.Л., Потапова Т.Н. и др. Значение генетических факторов в развитии целиакии. Вопросы современной педиатрии. 2010; 9 (4): 40–43.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Кондратьева Е.И., Пузырев В.П., Рудко А.А. и др. Поиск ассоциации полиморфных вариантов генов–модификаторов с целиакией у детей и подростков Томской области. Сибирский вестник гепатологии и гастроэнтерологии. 2006; 20: 68–72.</mixed-citation><mixed-citation xml:lang="en">Кондратьева Е.И., Пузырев В.П., Рудко А.А. и др. Поиск ассоциации полиморфных вариантов генов–модификаторов с целиакией у детей и подростков Томской области. Сибирский вестник гепатологии и гастроэнтерологии. 2006; 20: 68–72.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Petronzelli F., Bonamico M., Ferrante P. et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum. Genet. 1997; 61: 307–317.</mixed-citation><mixed-citation xml:lang="en">Petronzelli F., Bonamico M., Ferrante P. et al. Genetic contribution of the HLA region to the familial clustering of coeliac disease. Ann Hum. Genet. 1997; 61: 307–317.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Catassi C., Fasano A. Celiac disease. Curr. Оpin. Gastroenterol. 2008; 24: 687–691.</mixed-citation><mixed-citation xml:lang="en">Catassi C., Fasano A. Celiac disease. Curr. Оpin. Gastroenterol. 2008; 24: 687–691.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Holopainen P., Mustalahti K., Uimari P. et al. Candidate gene regions and genetic heterogeneity in gluten sensitivity. Gut. 2001; 48: 696–701.</mixed-citation><mixed-citation xml:lang="en">Holopainen P., Mustalahti K., Uimari P. et al. Candidate gene regions and genetic heterogeneity in gluten sensitivity. Gut. 2001; 48: 696–701.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL–10) in Down patients with coeliac disease. Dig. Liver Dis. 2005; 37 (12): 923–927.</mixed-citation><mixed-citation xml:lang="en">Evaluation of cytokine polymorphisms (TNFalpha, IFNgamma and IL–10) in Down patients with coeliac disease. Dig. Liver Dis. 2005; 37 (12): 923–927.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Ivarsson A., Persson L.A., Nystrom L. et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 2000; 89 (2): 165–171.</mixed-citation><mixed-citation xml:lang="en">Ivarsson A., Persson L.A., Nystrom L. et al. Epidemic of coeliac disease in Swedish children. Acta Paediatr. 2000; 89 (2): 165–171.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ivarsson A., Hernell O., Stenlund H., Persson L.A. Breast-feeding protects against celiac disease. Am. J. Clin. Nutr. 2002; 75 (5): 914–921.</mixed-citation><mixed-citation xml:lang="en">Ivarsson A., Hernell O., Stenlund H., Persson L.A. Breast-feeding protects against celiac disease. Am. J. Clin. Nutr. 2002; 75 (5): 914–921.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sandberg–Bennich S., Dahlquist G., Kallen B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002; 91 (1): 30–33.</mixed-citation><mixed-citation xml:lang="en">Sandberg–Bennich S., Dahlquist G., Kallen B. Coeliac disease is associated with intrauterine growth and neonatal infections. Acta Paediatr. 2002; 91 (1): 30–33.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Stene L.C., Honeyman M.C., Hoffenberg E.J. et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am. J. Gastroenterol. 2006; 101 (10): 2333–2340.</mixed-citation><mixed-citation xml:lang="en">Stene L.C., Honeyman M.C., Hoffenberg E.J. et al. Rotavirus infection frequency and risk of celiac disease autoimmunity in early childhood: a longitudinal study. Am. J. Gastroenterol. 2006; 101 (10): 2333–2340.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Plot L., Amital H. Infectious associations of celiac disease. Autoimmun. Rev. 2009; 8 (4): 316–319.</mixed-citation><mixed-citation xml:lang="en">Plot L., Amital H. Infectious associations of celiac disease. Autoimmun. Rev. 2009; 8 (4): 316–319.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Sandstrom O. Multifactorial etiology of celiac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009. Р. 11–13.</mixed-citation><mixed-citation xml:lang="en">Sandstrom O. Multifactorial etiology of celiac disease. Materials of CD–Medics Training Seminar «Coeliac disease a holistic approach». 2009. Р. 11–13.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Forsberg G., Fahlgren A., Horstedt P. et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am. J. Gastroenterol. 2004; 99: 894–904.</mixed-citation><mixed-citation xml:lang="en">Forsberg G., Fahlgren A., Horstedt P. et al. Presence of bacteria and innate immunity of intestinal epithelium in childhood celiac disease. Am. J. Gastroenterol. 2004; 99: 894–904.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Nadal I., Donant E., Ribes-Koninckx C. et al. Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J. Med. Microbiol. 2007; 56: 1669–1674.</mixed-citation><mixed-citation xml:lang="en">Nadal I., Donant E., Ribes-Koninckx C. et al. Imbalance in the composition of the duodenal microbiota of children with coeliac disease. J. Med. Microbiol. 2007; 56: 1669–1674.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 2002; 2: 647–655.</mixed-citation><mixed-citation xml:lang="en">Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat. Rev. Immunol. 2002; 2: 647–655.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Бельмер С.В., Гасилина Т.В. Возможные и невозможные механизмы повреждения слизистой оболочки тонкой кишки при целиакии. В кн.: Целиакия у детей. Под ред. С.В. Бельмер, М.О. Ревнова. М.: Медпрактика–М. 2010. С. 58–89.</mixed-citation><mixed-citation xml:lang="en">Бельмер С.В., Гасилина Т.В. Возможные и невозможные механизмы повреждения слизистой оболочки тонкой кишки при целиакии. В кн.: Целиакия у детей. Под ред. С.В. Бельмер, М.О. Ревнова. М.: Медпрактика–М. 2010. С. 58–89.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Van de Wal Y., Kooy Y., van Veelen P. et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin specific T cell reactivity. J. Immunol. 1998; 161: 1585–1588.</mixed-citation><mixed-citation xml:lang="en">Van de Wal Y., Kooy Y., van Veelen P. et al. Selective deamidation by tissue transglutaminase strongly enhances gliadin specific T cell reactivity. J. Immunol. 1998; 161: 1585–1588.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Arentz–Hansen H., Korner R., Molberg O. et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J. Exp. Med. 2000; 191: 603–612.</mixed-citation><mixed-citation xml:lang="en">Arentz–Hansen H., Korner R., Molberg O. et al. The intestinal T cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J. Exp. Med. 2000; 191: 603–612.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Alaedini A., Green P. Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder. Ann. Intern. Med. 2005; 142: 289–298.</mixed-citation><mixed-citation xml:lang="en">Alaedini A., Green P. Narrative Review: Celiac Disease: Understanding a Complex Autoimmune Disorder. Ann. Intern. Med. 2005; 142: 289–298.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Marsh M.N. Mucosal pathology in gluten sensitivity. In: Coeliac Disease. Ed. M.N. Marsh. Oxford: Blackwell Scientific Publications. 1992. Р. 136–191.</mixed-citation><mixed-citation xml:lang="en">Marsh M.N. Mucosal pathology in gluten sensitivity. In: Coeliac Disease. Ed. M.N. Marsh. Oxford: Blackwell Scientific Publications. 1992. Р. 136–191.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Jabri B., de Serre N.P., Cellier C. et al. Selective expansion of intraepithelial lymphocytes expressing the HLA–E specific natural killer receptor CD94 in celiac disease. Gastroenterol. 2000; 118: 867–879.</mixed-citation><mixed-citation xml:lang="en">Jabri B., de Serre N.P., Cellier C. et al. Selective expansion of intraepithelial lymphocytes expressing the HLA–E specific natural killer receptor CD94 in celiac disease. Gastroenterol. 2000; 118: 867–879.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Hьe S., Mention J.J., Monteiro R.C. et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004; 21: 367–377.</mixed-citation><mixed-citation xml:lang="en">Hьe S., Mention J.J., Monteiro R.C. et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity. 2004; 21: 367–377.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Meresse B., Chen Z., Ciszewski C. et al. Coordinated induction by IL15 of a TCR independent NKG2D signaling pathway converts CTL into lymphokine activated killer cells in celiac disease. Immunity. 2004; 21: 357–366.</mixed-citation><mixed-citation xml:lang="en">Meresse B., Chen Z., Ciszewski C. et al. Coordinated induction by IL15 of a TCR independent NKG2D signaling pathway converts CTL into lymphokine activated killer cells in celiac disease. Immunity. 2004; 21: 357–366.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Sollid L.M., Jabri B. Is celiac disease an autoimmune disorder? Curr. Opin. Immunol. 2005; 17: 595–600.</mixed-citation><mixed-citation xml:lang="en">Sollid L.M., Jabri B. Is celiac disease an autoimmune disorder? Curr. Opin. Immunol. 2005; 17: 595–600.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Maiuri L., Ciacci C., Ricciardelli I. et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 2003; 362: 30–37.</mixed-citation><mixed-citation xml:lang="en">Maiuri L., Ciacci C., Ricciardelli I. et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet. 2003; 362: 30–37.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Dickey W., Hughes D.F., McMillan S.A. Patients with serum IgA endomysial antibodies and intact duodenal villi: clinical characteristics and management options. Scand. J. Gastroenterol. 2005; 40: 1240–1243.</mixed-citation><mixed-citation xml:lang="en">Dickey W., Hughes D.F., McMillan S.A. Patients with serum IgA endomysial antibodies and intact duodenal villi: clinical characteristics and management options. Scand. J. Gastroenterol. 2005; 40: 1240–1243.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Hill I.D., Dirks M.H., Liptak G.S. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 2005; 40: 1–19.</mixed-citation><mixed-citation xml:lang="en">Hill I.D., Dirks M.H., Liptak G.S. et al. Guideline for the diagnosis and treatment of celiac disease in children: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J. Pediatr. Gastroenterol. Nutr. 2005; 40: 1–19.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
