vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v14i2.1295vsp-67Research ArticleОБМЕН ОПЫТОМEXCHANGE OF EXPERIENCEДИСФУНКЦИИ ИММУНИТЕТА ПРИ РЕСПИРАТОРНЫХ ЗАБОЛЕВАНИЯХ: НУЖНЫ ЛИ ИММУНОМОДУЛЯТОРЫ У ЧАСТО БОЛЕЮЩИХ ДЕТЕЙ?IMMUNITY DYSFUNCTION IN RESPIRATORY DISEASES: DO FREQUENTLY ILL CHILDREN NEED IMMUNOMODULATORS?КарауловА. В.KaraulovA. V.

доктор медицинских наук, профессор, член-корреспондент РАН, заведующий кафедрой клинической иммунологии и аллергологии Первого МГМУ им. И.М. Сеченова Адрес: 119992, Москва, ул. Трубецкая, д. 8, стр. 2, тел.: +7 (495) 395-64-97

 

drkaraulov@mail.ruПервый Московский государственный медицинский университет им. И.М. Сеченова, Российская ФедерацияРоссияI.M. Sechenov First Moscow State Medical University, Russian FederationRussian Federation201517042015142Вопросы современной педиатрии260264Copyright © Караулов А.В., 20152015Караулов А.В.Karaulov A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/67

Недостаточно эффективный контроль многих инфекционных болезней при помощи этиотропных химиопрепаратов определяет актуальность поиска альтернативных методов, в частности, основанных на модуляции иммунитета. В обзоре современной литературы проанализированы рациональные подходы при дисфункции иммунитета у часто болеющих детей. Обращается внимание на то, что применение иммуномодуляторов способствует снижению частоты и уменьшению степени тяжести респираторных заболеваний, предупреждает развитие осложнений. Рассмотрены преимущества применения инозина пранобекса, сочетающего свойства иммуномодулятора с прямой противовирусной активностью. Продемонстрирована возможность использования инозина пранобекса для профилактики и лечения респираторных инфекций у часто болеющих детей, представлены рациональные схемы его применения.

 

Insufficient control of many infectious diseases using etiotropic drugs determines the relevance of a search for alternative methods, in particular based on the modulation of the immune system. The review of recent literature analyzes rational approaches to the immunity dysfunction in frequently ill children. Attention is drawn to the fact that the use of immunomodulators reduces the frequency and severity of respiratory diseases and prevents complications. The article examines the advantages of the use of inosine pranobex that combines the properties of an immunomodulator and a direct antiviral activity. It is shown that inosine pranobex can be used for the prevention and treatment of respiratory infections in frequently ill children, and the rational schemes of its application are presented.

 

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The authors declare that there are no conflicts of interest present.