vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v14i2.1304vsp-76Research ArticleКЛИНИЧЕСКИЕ НАБЛЮДЕНИЯCLINICAL OBSERVATIONSЭФФЕКТИВНОСТЬ АБАТАЦЕПТА У ПАЦИЕНТА С ПОЛИАРТИКУЛЯРНЫМ ЮВЕНИЛЬНЫМ ИДИОПАТИЧЕСКИМ АРТРИТОМ, РЕЗИСТЕНТНЫМ К ИНГИБИТОРАМ ФНО ΑEFFICACY OF ABATACEPT IN A PATIENT WITH POLYARTICULAR JUVENILE IDIOPATHIC ARTHRITIS REFRACTORY TO TNF-αСпиваковскийЮ. М.SpivakovskiiYu. M.

кандидат медицинских наук, доцент кафедры госпитальной педиатрии и неонатологии Саратовского ГМУ им. В.И. Разумовского Адрес: 410012, Саратов, ул. Большая Казачья, д. 112, тел.: +7 (8452) 39-08-02

spivakovski65@mail.ruЧерненковЮ. В.ChernenkovYu. V.spivakovski65@mail.ruСпиваковскаяА. Ю.SpivakovskayaA. Yu.spivakovski65@mail.ruСкуповаО. В.SkupovaO. V.spivakovski65@mail.ruШульгинаЕ. Н.Shul'ginaE. N.spivakovski65@mail.ruСаратовский государственный медицинский университет им. В.И. Разумовского, Российская ФедерацияРоссияV.I. Razumovskii Saratov State Medical University, Saratov, Russian FederationRussian Federation201517042015142Вопросы современной педиатрии305308Copyright © Спиваковский Ю.М., Черненков Ю.В., Спиваковская А.Ю., Скупова О.В., Шульгина Е.Н., 20152015Спиваковский Ю.М., Черненков Ю.В., Спиваковская А.Ю., Скупова О.В., Шульгина Е.Н.Spivakovskii Y.M., Chernenkov Y.V., Spivakovskaya A.Y., Skupova O.V., Shul'gina E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/76

Рассмотрен пример применения генно-инженерного биологического препарата, ингибитора костимуляции Т лимфоцитов абатацепта, в стандартной дозировке у ребенка с полиартикулярным вариантом ювенильного идиопатического артрита. Заболевание характеризовалось развитием полиартрита, увеита, а также неэффективностью двух ингибиторов фактора некроза опухоли α. Абатацепт в комбинации с метотрексатом обеспечил снижение клинических и лабораторных показателей активности болезни, улучшение функции суставов.

 

The article describes the experience of the application of genetically engineered biological drug and an inhibitor of T lymphocyte costimulation – abatacept – at a standard dose in a child with polyarticular juvenile idiopathic arthritis. The disease was characterized by the development of uveitis, as well as the ineffectiveness of two inhibitors of tumour necrosis factor α treatment. Successful relief of acute inflammatory reaction of the joints on the background of the normalization of laboratory indicators of disease severity in the application of abatacept in combination with methotrexate was detected. The study gave the characteristics of the dynamics of clinical recovery of the patient and described the dynamic changes of clinical and laboratory symptoms. A steady improvement of the child under nine-month follow-up on the background of the selected scheme basic anti-inflammatory therapy should be noted.

 

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The authors declare that there are no conflicts of interest present.