vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»10.15690/vsp.v14i1.1261vsp-80Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWО ДОЗИРОВАНИИ ВИТАМИНА D У ДЕТЕЙ И ПОДРОСТКОВDOSAGE OF VITAMIN D IN CHILDREN AND ADOLESCENTSГромоваО. А.GromovaO. A.

доктор медицинских наук, профессор кафедры фармакологии и клинической фармакологии ИвГМА, научный консультант Российского сотрудничающего центра «Нейробиология» института микроэлементов ЮНЕСКО

unesco.gromova@gmail.comТоршинИ. Ю.TorshinI. Yu.unesco.gromova@gmail.comЗахароваИ. Н.ZakharovaI. N.zakharova-rmapo@yandex.ruСпиричевВ. Б.SpirichevV. B.unesco.gromova@gmail.comЛимановаО. А.LimanovaO. A.unesco.gromova@gmail.comБоровикТ. Э.BorovikT. E.borovik@nczd.ruЯцыкГ. В.YatsykG V.borovik@nczd.ruИвановская государственная медицинская академия, Российская ФедерацияРоссияIvanovo State Medical Academy, Russian FederationRussian FederationМосковский физико-технический институт, Российская ФедерацияРоссияMoscow Institute of Physics and Technology, Russian FederationRussian FederationРоссийская медицинская академия последипломного образования, Москва, Российская ФедерацияРоссияRussian Medical Academy of Postgraduate Education, Moscow, Russian FederationRussian FederationНИИ питания, Москва, Российская ФедерацияРоссияResearch Institute of Nutrition, Moscow, Russian FederationRussian FederationНаучный центр здоровья детей, Москва, Российская Федерация Первый Московский государственный медицинский университет им. И.М. Сеченова, Российская ФедерацияРоссияScientific Centre of Children Health, Moscow, Russian Federation Sechenov First Moscow State Medical University, Russian FederationRussian FederationНаучный центр здоровья детей, Москва, Российская ФедерацияРоссияScientific Centre of Children Health, Moscow, Russian FederationRussian Federation201514022015141Вопросы современной педиатрии3847Copyright © Громова О.А., Торшин И.Ю., Захарова И.Н., Спиричев В.Б., Лиманова О.А., Боровик Т.Э., Яцык Г.В., 20152015Громова О.А., Торшин И.Ю., Захарова И.Н., Спиричев В.Б., Лиманова О.А., Боровик Т.Э., Яцык Г.В.Gromova O.A., Torshin I.Y., Zakharova I.N., Spirichev V.B., Limanova O.A., Borovik T.E., Yatsyk G.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/80

Данные современных фундаментальных и клинических исследований демонстрируют, что повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей (400–500 МЕ/сут) существенно занижены. В статье представлены результаты обзорных и клинических исследований (n =21), в которых зафиксирована положительная динамика концентрации 25(OH)D в плазме крови на фоне применения витамина D у детей и подростков в возрасте от 0 до 18 лет. Продолжительность приема витамина D в проанализированных исследованиях составила от 1 до 12 мес, доза — от 800 до 4000 МЕ/сут. По результатам повозрастного анализа предложена ступенчатая схема назначения витамина D: для детей в возрасте до 4 мес рекомендуется ежедневный прием 500 МЕ/сут (для недоношенных — 800–1000 МЕ/сут), в возрасте от 4 мес до 4 лет — 1000 МЕ/сут, 4–10 лет — 1500 МЕ/сут, 10–16 лет — 2000 МЕ/сут витамина в течение года. При этом достигается эффективная компенсация дефицита витамина D (концентрация 25(OH)D >20 нг/мл), а также, по некоторым данным, снижение риска развития инфекционных и аллергических заболеваний. Показана безопасность рекомендуемого режима приема витамина D.

 

The data of modern basic and clinical studies demonstrate that commonly used rates of the recommended daily intake of vitamin D for children (400–500 IU/day) are significantly underestimated. The article presents the results of survey and clinical studies (n =21), in which the positive dynamics of 25(OH)D concentration in the blood plasma during intake of vitamin D is noted in children and adolescents aged from 0 to 18 years. The duration of vitamin D intake in the analysed studies was from 1 to 12 months, the dose — from 800 to 4000 IU/day. According to the results of the age-specific analysis, the staircase scheme of vitamin D prescription is offered: for children aged under 4 months the daily intake of 500 IU/day of the vitamin is recommended during a year (for premature — 800-1000 IU/day), aged from 4 months to 4 years — 1000 IU/day, 4–10 years — 1500 IU/day, 10–16 years — 2000 IU/day. Therewith, this achieves the effective compensation of vitamin D deficiency (25(OH)D concentration >20 ng/ml), and also, according to some reports, the reduction of risks of infectious and allergic diseases. Safety of the recommended vitamin D intake mode is shown.

 

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The authors declare that there are no conflicts of interest present.