vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»vsp-831Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWПРИМЕНЕНИЕ БУДЕСОНИДА У ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТАBUDESONIDE TREATMENT IN CHILDREN PRESCHOOL AGEВишневаЕ.А.VishnevaE.A.Намазова-БарановаЛ.С.Namazova-BaranovaL.S.ТоршхоеваР.М.TorshkhoevaR.M.ЛевинаЮ.Г.LevinaYu.G.АлексееваА.А.AlekseevaA.A.ЭфендиеваК.Е.EfendievaK.E.Научный центр здоровья детей РАМН, МоскваРоссияScientific Center of Children’s Health, Russian Academy of Medical Sciences, MoscowRussian Federation20101409201591Вопросы современной педиатрии7680Copyright © Вишнева Е., Намазова-Баранова Л., Торшхоева Р., Левина Ю., Алексеева А., Эфендиева К., 20102010Вишнева Е., Намазова-Баранова Л., Торшхоева Р., Левина Ю., Алексеева А., Эфендиева К.Vishneva E., Namazova-Baranova L., Torshkhoeva R., Levina Y., Alekseeva A., Efendieva K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/831

Бронхиальная астма остается широко распространенным заболеванием среди детей как младшего, так и старшего возраста. Ингаляционные кортикостероиды являются препаратами первой линии в терапии бронхиальной астмы у детей всех возрастов. В статье освещен вопрос применения будесонида (Пульмикорт) у дошкольников. Приведены данные различных исследований, подтверждающих эффективность и безопасность использования как турбухалера, так и небулированной формы препарата.

Ключевые слова: дети, бронхиальная астма, ингаляционные кортикостероиды, будесонид.(Вопросы современной педиатрии. 2010;9(1):76-80)

Bronchial asthma remains disease with wide prevalence in children different age. Inhalation corticosteroids are medications of first line of therapy in children. The article describes the ways of treatment with budesonide (Pulmicort) in children preschool age. The data from different studies prove the effectiveness and safety of treatment with as turbuhaler, as nebulizer form of this drug. 

Key words: children, bronchial asthma, inhalational corticosteroids, budesonide.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(1):76-80)

ReferencesАллергология и иммунология. Под общей ред. А.А. Баранова, Р.М. Хаитова. М.: М–студио. 2008. 240 с.Аллергология и иммунология. Под общей ред. А.А. Баранова, Р.М. Хаитова. М.: М–студио. 2008. 240 с.Asthma prevalence, health care use and mortality. National Center for Health Statistics, 2008. URL: http://www.cdc.gov/nchs/fastats/asthma.htm.Asthma prevalence, health care use and mortality. National Center for Health Statistics, 2008. URL: http://www.cdc.gov/nchs/fastats/asthma.htm.Emerman C.L., Cydulka R.K., Crain E.F. et al. Prospective multicenter study of relapse after treatment for acute asthma among children presenting to the emergency department. J. Pediatr. 2001; 138: 318–324.Emerman C.L., Cydulka R.K., Crain E.F. et al. Prospective multicenter study of relapse after treatment for acute asthma among children presenting to the emergency department. J. Pediatr. 2001; 138: 318–324.Stevens M.W., Gorelick M.H. Short term outcomes after acute treatment of pediatric asthma. Pediatrics. 2001; 107: 1357–1362.Stevens M.W., Gorelick M.H. Short term outcomes after acute treatment of pediatric asthma. Pediatrics. 2001; 107: 1357–1362.Bloomberg G.R., Trinkaus K.M., Fisher E.B. Jr. et al. Hospital readmissions for childhood asthma: a 10-year metropolitan study. Am. J. Respir. Crit. Care Med. 2003; 167: 1068–1076.Bloomberg G.R., Trinkaus K.M., Fisher E.B. Jr. et al. Hospital readmissions for childhood asthma: a 10-year metropolitan study. Am. J. Respir. Crit. Care Med. 2003; 167: 1068–1076.Mitchell E.A., Bland J.M., Thompson J.M. Risk factors for readmission to hospital for asthma in childhood. Thorax. 1994; 49: 33–36.Mitchell E.A., Bland J.M., Thompson J.M. Risk factors for readmission to hospital for asthma in childhood. Thorax. 1994; 49: 33–36.Schaubel D., Johansen H., Mao Y. et al. Risk of preschool asthma: incidence, hospitalization, recurrence, and readmission probability. J. Asthma. 1996; 33: 97–103.Schaubel D., Johansen H., Mao Y. et al. Risk of preschool asthma: incidence, hospitalization, recurrence, and readmission probability. J. Asthma. 1996; 33: 97–103.Weiss K.B., Gergen P.J., Hodgson T.A. An economic evaluation of asthma in the United States. N. Engl. J. Med. 1992; 326: 862–866.Weiss K.B., Gergen P.J., Hodgson T.A. An economic evaluation of asthma in the United States. N. Engl. J. Med. 1992; 326: 862–866.National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma update on selected topics – 2002. J. Allergy Clin. Immunol. 2002; 110: 141–219.National Asthma Education and Prevention Program. Expert Panel Report: guidelines for the diagnosis and management of asthma update on selected topics – 2002. J. Allergy Clin. Immunol. 2002; 110: 141–219.Donahue J.G., Weiss S.T., Livingston J.M. et al. Inhaled steroids and the risk of hospitalization for asthma. JAMA. 1997; 277: 887–891.Donahue J.G., Weiss S.T., Livingston J.M. et al. Inhaled steroids and the risk of hospitalization for asthma. JAMA. 1997; 277: 887–891.Sin D.D., Man S.F. Low dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch. Intern. Med. 2002; 162: 1591–1595.Sin D.D., Man S.F. Low dose inhaled corticosteroid therapy and risk of emergency department visits for asthma. Arch. Intern. Med. 2002; 162: 1591–1595.Stempel D.A., Pinto L., Stanford R.H. The risk of hospitalization in patients with asthma switched from an inhaled corticosteroid to a leukotriene receptor antagonist. J. Allergy Clin. Immunol. 2002; 110: 39–41.Stempel D.A., Pinto L., Stanford R.H. The risk of hospitalization in patients with asthma switched from an inhaled corticosteroid to a leukotriene receptor antagonist. J. Allergy Clin. Immunol. 2002; 110: 39–41.Suissa S., Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J. Allergy Clin. Immunol. 2001; 107: 937–944.Suissa S., Ernst P. Inhaled corticosteroids: impact on asthma morbidity and mortality. J. Allergy Clin. Immunol. 2001; 107: 937–944.Kofman C., Berlinski A., Zaragoza S. et al. Aerosol therapy for pediatric outpatients. J. Resp. Care Pract. 2004. URL: http://www.rtmagazine. com/issues/articles/2004-03_05.asp.Kofman C., Berlinski A., Zaragoza S. et al. Aerosol therapy for pediatric outpatients. J. Resp. Care Pract. 2004. URL: http://www.rtmagazine. com/issues/articles/2004-03_05.asp.McLaughlin T., Leibman C. Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications. Curr. Med. Res. Opin. 2007; 23 (6): 1319–1328.McLaughlin T., Leibman C. Risk of recurrent emergency department visits or hospitalizations in children with asthma receiving nebulized budesonide inhalation suspension compared with other asthma medications. Curr. Med. Res. Opin. 2007; 23 (6): 1319–1328.Baker J.W., Mellon M., Wald J. et al. A multiple dosing, placebo controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants. Pediatrics.1999; 103 (2): 414–421.Baker J.W., Mellon M., Wald J. et al. A multiple dosing, placebo controlled study of budesonide inhalation suspension given once or twice daily for treatment of persistent asthma in young children and infants. Pediatrics.1999; 103 (2): 414–421.Shapiro G., Mendelson L., Kraemer M.J. et al. Efficacy and safety of budesonide inhalation suspension (Pulmicort Respules) in young children with inhaled steroid dependent, persistent asthma. J. Allergy Clin. Immunol. 1998; 102: 789–796.Shapiro G., Mendelson L., Kraemer M.J. et al. Efficacy and safety of budesonide inhalation suspension (Pulmicort Respules) in young children with inhaled steroid dependent, persistent asthma. J. Allergy Clin. Immunol. 1998; 102: 789–796.Szefler S., Pedersen S. Role of budesonide as maintenance therapy for children with asthma. Pediatric. Pulm. 2003; 36 (1): 13–21.Szefler S., Pedersen S. Role of budesonide as maintenance therapy for children with asthma. Pediatric. Pulm. 2003; 36 (1): 13–21.Berger W.E., Shapiro G.G. The use of inhaled corticosteroids for persistent asthma in infants and young children. Ann. Allergy Asthma Immunol. 2004; 92: 387–400.Berger W.E., Shapiro G.G. The use of inhaled corticosteroids for persistent asthma in infants and young children. Ann. Allergy Asthma Immunol. 2004; 92: 387–400.Jonasson G., Carlsen K.H., Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch. Dis. Child. 2000; 83: 330–333.Jonasson G., Carlsen K.H., Mowinckel P. Asthma drug adherence in a long term clinical trial. Arch. Dis. Child. 2000; 83: 330–333.Turpeinen M., the HEICA Study Group. Helsinki Early Intervention Childhood Asthma (HEICA) study: Inhaled budesonide halved the number of asthma exacerbations compared with inhaled disodium cromoglycate during 18 months of treatment. Eur. Respir. J. 2000; 16: 311.Turpeinen M., the HEICA Study Group. Helsinki Early Intervention Childhood Asthma (HEICA) study: Inhaled budesonide halved the number of asthma exacerbations compared with inhaled disodium cromoglycate during 18 months of treatment. Eur. Respir. J. 2000; 16: 311.Storm Van's Gravesande K., Mattes J., Endlicher A. et al. Effect of two doses of budesonide on exhaled nitric oxide and urinary EPX excretion in asthmatic children. Pneumologie. 2004; 58 (7): 483–488.Storm Van's Gravesande K., Mattes J., Endlicher A. et al. Effect of two doses of budesonide on exhaled nitric oxide and urinary EPX excretion in asthmatic children. Pneumologie. 2004; 58 (7): 483–488.Shapiro G.G., Mendelson L.M., Pearlman D.S. Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) maintains pulmonary function and symptoms of asthmatic children previously receiving inhaled corticosteroids. Ann. Allergy Asthma Immunol. 2001; 86: 633–640.Shapiro G.G., Mendelson L.M., Pearlman D.S. Once-daily budesonide inhalation powder (Pulmicort Turbuhaler) maintains pulmonary function and symptoms of asthmatic children previously receiving inhaled corticosteroids. Ann. Allergy Asthma Immunol. 2001; 86: 633–640.Szefler S.J., Eigen H. Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma. J. Allergy Clin. Immunol. 2002; 109 (4): 730–742.Szefler S.J., Eigen H. Budesonide inhalation suspension: a nebulized corticosteroid for persistent asthma. J. Allergy Clin. Immunol. 2002; 109 (4): 730–742.Guilbert T.W., Morgan W.J., Zeiger R.S. et al. Long term inhaled corticosteroids in preschool children at high risk for asthma. NEJM. 2006; 354: 1985–1997.Guilbert T.W., Morgan W.J., Zeiger R.S. et al. Long term inhaled corticosteroids in preschool children at high risk for asthma. NEJM. 2006; 354: 1985–1997.

The authors declare that there are no conflicts of interest present.