vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»vsp-878Research ArticleВ ПОМОЩЬ ВРАЧУA DOCTOR’S AIDАКТУАЛЬНОСТЬ ПРИМЕНЕНИЯ НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ СРЕДСТВ ДЛЯ ЛЕЧЕНИЯ ЛИХОРАДКИ У ДЕТЕЙTOPICALITY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS IN TREATMENT OF FEVER IN CHILDRENМубаракшинаО.А.MubarakshinaO.A.Воронежская государственная медицинская академия им. Н.Н. БурденкоРоссияN.N. Burdenko Voronezh State Medical AcademyRussian Federation20101409201592Вопросы современной педиатрии156160Copyright © Мубаракшина О., 20102010Мубаракшина О.Mubarakshina O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/878

Нестероидные противовоспалительные препараты широко применяются в педиатрической практике для лечения лихорадки у детей. При выборе средств этой группы для назначения детям особенно важно ориентироваться на высокоэффективные препараты с наименьшим риском возникновения побочных реакций. Этим требованиям в полной мере сегодня отвечают только парацетамол и ибупрофен. Они официально рекомендуются ВОЗ в качестве жаропонижающих средств для использования в педиатрии. В статье рассматриваются преимущества ибупрофена в сравнении с парацетамолом, приводятся данные рандомизированных исследований. Уделено внимание вопросам безопасности при лечении ибупрофеном и возможностям комбинированной терапии ибупрофеном и парацетамолом.

Ключевые слова: дети, лихорадка, ибупрофен, парацетамол, лечение.(Вопросы современной педиатрии. 2010;9(2):156-160)

Nonsteroidal anti-inflammatory drugs are widely used in pediatric practice for the treatment of fever. The choice of the drug from this group must be based on high effectiveness of medication and the lowest risk of adverse events. Only paracetamol and ibuprofen completely fulfill these requirements at the present times. They are officially recommended by WHO for the use as an anti-fever pediatric medication. The article examines advantages of ibuprofen compared to paracetamol on the basis of results of randomized studies. Author describes a safety of ibuprofen and opportunities of combined treatment with ibuprofen and paracetamol.

Key words: children, fever, ibuprofen, paracetamol, treatment.(Voprosy sovremennoi pediatrii — Current Pediatrics. 2010;9(2):156-160)

ReferencesSidler J., Frey B., Baerlocher K. A double-blind comparison of ibuprofen and paracetamol in juvenile pyrexia. Br. J. Clin. Pract. 1990; 70: 22–25.Sidler J., Frey B., Baerlocher K. A double-blind comparison of ibuprofen and paracetamol in juvenile pyrexia. Br. J. Clin. Pract. 1990; 70: 22–25.Walson P., Galletta G., Braden N. et al. Ibuprofen, acetaminophen, and placebo treatment of febrile children. Clin. Pharmacol. Ther. 1989; 46: 9–17.Walson P., Galletta G., Braden N. et al. Ibuprofen, acetaminophen, and placebo treatment of febrile children. Clin. Pharmacol. Ther. 1989; 46: 9–17.Bertin L., Pons G., d'Athis P. et al. Randomised, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children. J. Pediatrics. 1991; 119 (5): 811–814.Bertin L., Pons G., d'Athis P. et al. Randomised, double-blind, multicenter, controlled trial of ibuprofen versus acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in children. J. Pediatrics. 1991; 119 (5): 811–814.Bertin L., Pons G., d'Athis P. et al. A randomised, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundam. Clin. Pharmacol. 1996; 10: 387–392.Bertin L., Pons G., d'Athis P. et al. A randomised, double-blind, multicentre controlled trial of ibuprofen versus acetaminophen and placebo for symptoms of acute otitis media in children. Fundam. Clin. Pharmacol. 1996; 10: 387–392.Lesko S. The safety of acetaminophen and ibuprofen among children less than two years old. Pediatrics. 1999; 104 (4): 1–5.Lesko S. The safety of acetaminophen and ibuprofen among children less than two years old. Pediatrics. 1999; 104 (4): 1–5.Lesko S., Louic C., Vezina R. et al. Asthma morbidity after he short–term use of ibuprofen in children. Pediatrics. 2002; 109 (2):1–4.Lesko S., Louic C., Vezina R. et al. Asthma morbidity after he short–term use of ibuprofen in children. Pediatrics. 2002; 109 (2):1–4.Kauffmann R., Sawyer L., Scheinbaum M. Antipyretic efficacy of ibuprofen VS acetaminophen. AJDC. 1992; 146: 622–625.Kauffmann R., Sawyer L., Scheinbaum M. Antipyretic efficacy of ibuprofen VS acetaminophen. AJDC. 1992; 146: 622–625.Czaykowski D., Fratarcangelo P., Rosefsky J. Evaluation of the antipyretic efficacy of single dose ibuprofen suspension compared to acetaminophen elixir in febrile children. Pediatric Research. 1994; 35 (4): 829.Czaykowski D., Fratarcangelo P., Rosefsky J. Evaluation of the antipyretic efficacy of single dose ibuprofen suspension compared to acetaminophen elixir in febrile children. Pediatric Research. 1994; 35 (4): 829.Lesko S., Mitchell A. Renal function after short term ibuprofen use in infants and children. Pediatrics. 1997; 100: 954–957.Lesko S., Mitchell A. Renal function after short term ibuprofen use in infants and children. Pediatrics. 1997; 100: 954–957.Autret E., Breart G., Jonville A. et al. Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. Eur J. Clin. Pharmacol. 1994; 46 (3): 197–201.Autret E., Breart G., Jonville A. et al. Comparative efficacy and tolerance of ibuprofen syrup and acetaminophen syrup in children with pyrexia associated with infectious diseases and treated with antibiotics. Eur J. Clin. Pharmacol. 1994; 46 (3): 197–201.Wilson J., Brown R., Kearns G. et al. Single-dose, placebocontrolled comparative study of ibuprofen and acetaminophen antipyresis in children. J. Pediatr. 1991; 119 (5): 803–811.Wilson J., Brown R., Kearns G. et al. Single-dose, placebocontrolled comparative study of ibuprofen and acetaminophen antipyresis in children. J. Pediatr. 1991; 119 (5): 803–811.Hay A., Costelloe C., Redmond N. et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ. 2008; 337: 302.Hay A., Costelloe C., Redmond N. et al. Paracetamol plus ibuprofen for the treatment of fever in children (PITCH): randomised controlled trial. BMJ. 2008; 337: 302.

The authors declare that there are no conflicts of interest present.