vspВопросы современной педиатрииCurrent Pediatrics1682-55271682-5535Издательство «ПедиатрЪ»vsp-972Research ArticleОБЗОРЫ ЛИТЕРАТУРЫLITERATURE REVIEWЗНАЧЕНИЕ КИШЕЧНОЙ МИКРОБИОТЫ И ПРОБИОТИКОВ ДЛЯ ФОРМИРОВАНИЯ ИММУННОГО ОТВЕТА И ЗДОРОВЬЯ РЕБЕНКАINTESTINAL MICROBIOCENOSIS AND PROBIOTICS IN FORMATION OF IMMUNE RESPONSE AND HEALTH OF CHILDRENБулатоваЕ.М.BulatovaE.M.БогдановаН.М.BogdanovaN.M.Санкт-Петербургская государственная педиатрическая медицинская академияРоссияSt.-Petersburg State Pediatric Medical AcademyRussian Federation20101709201596Вопросы современной педиатрии3744Copyright © Булатова Е., Богданова Н., 20102010Булатова Е., Богданова Н.Bulatova E., Bogdanova N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://vsp.spr-journal.ru/jour/article/view/972ReferencesAndresen V., Camilleri M. Irritable bowel syndrome: recent and novel therapeutic approaches. Drugs. 2006; 66(8): 1073–1088.Andresen V., Camilleri M. Irritable bowel syndrome: recent and novel therapeutic approaches. Drugs. 2006; 66(8): 1073–1088.Kassinen A., Krogius-Kurikka L., Mäkivuokko H. et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 2007; 133(1): 24–33.Kassinen A., Krogius-Kurikka L., Mäkivuokko H. et al. The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects. Gastroenterology. 2007; 133(1): 24–33.Sartor R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008; 134(2): 577–594.Sartor R.B. Microbial influences in inflammatory bowel diseases. Gastroenterology. 2008; 134(2): 577–594.Rachmilewitz D., Katakura K., Karmeli F. et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004; 126(2): 520–528.Rachmilewitz D., Katakura K., Karmeli F. et al. Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology. 2004; 126(2): 520–528.Reinhardt C., Reigstad C.S., Bäckhed F. Intestinal microbiota during infancy and its implications for obesity. J. Pediatr. Gastroenterol. Nutr. 2009; 48(3): 249–256.Reinhardt C., Reigstad C.S., Bäckhed F. Intestinal microbiota during infancy and its implications for obesity. J. Pediatr. Gastroenterol. Nutr. 2009; 48(3): 249–256.Grunland M., Guimonde M., Laitinen K. Maternal breast milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin. Experimental Allergy. 2007; 111: 1–9.Grunland M., Guimonde M., Laitinen K. Maternal breast milk and intestinal bifidobacteria guide the compositional development of the Bifidobacterium microbiota in infants at risk of allergic disease. Clin. Experimental Allergy. 2007; 111: 1–9.Newburg D.S., Walker W.A. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr. Res. 2007; 61(1): 2–8.Newburg D.S., Walker W.A. Protection of the neonate by the innate immune system of developing gut and of human milk. Pediatr. Res. 2007; 61(1): 2–8.Walker W.A., Dai D. Protective nutrients for the immature gut. In: Ziegler EELA, Moro GE (eds) Nutrition of the very low birth weight infant. Philadelphia: Lippincott Williams and Wilkins. 1999. Р. 179–197.Walker W.A., Dai D. Protective nutrients for the immature gut. In: Ziegler EELA, Moro GE (eds) Nutrition of the very low birth weight infant. Philadelphia: Lippincott Williams and Wilkins. 1999. Р. 179–197.Palmer C., Bik E.M., Di Giulio D.B. et al. Development of the human infant intestinal microbiota. PLoS Biol. 2007; 5 (7): 177.Palmer C., Bik E.M., Di Giulio D.B. et al. Development of the human infant intestinal microbiota. PLoS Biol. 2007; 5 (7): 177.Raylich-Stoyanovich M., Shmidt H. And once again about variety gastrointestinal микробиоты in organism of the person. Appl. Environ Microbiol. 2007; 9: 2125–2136.Raylich-Stoyanovich M., Shmidt H. And once again about variety gastrointestinal микробиоты in organism of the person. Appl. Environ Microbiol. 2007; 9: 2125–2136.Lezer T.D., Molibak L. Survival in condition of the activities microbe: positive influence microbiota mammals on master. Appl. Environ Microbiol. 2009; 11: 2194–2206.Lezer T.D., Molibak L. Survival in condition of the activities microbe: positive influence microbiota mammals on master. Appl. Environ Microbiol. 2009; 11: 2194–2206.Шендеров Б.А. Медицинская микробная экология и функциональное питание. М. 1998.Шендеров Б.А. Медицинская микробная экология и функциональное питание. М. 1998.Осипов Г.А. Хромато-масс-спектрометрическое исследование микроорганизмов и их сообществ. Автореф. дис. ... докт. биол. наук. М. 1995.Осипов Г.А. Хромато-масс-спектрометрическое исследование микроорганизмов и их сообществ. Автореф. дис. ... докт. биол. наук. М. 1995.Zoetendal E.G., Akkermans A.D., De Vos W.M. Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host specific communities of active bacteria. Appl. Environ Microbiol. 1998; 64 (10): 3854–3849.Zoetendal E.G., Akkermans A.D., De Vos W.M. Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host specific communities of active bacteria. Appl. Environ Microbiol. 1998; 64 (10): 3854–3849.Тамм А.О., Вия М.П., Микельсаар М.Э. и др. Метаболиты кишечной микрофлоры в диагностике дисбиоза кишечника. Антибиотики и медицинская биотехнология. 1987; 32 (3): 191–195.Тамм А.О., Вия М.П., Микельсаар М.Э. и др. Метаболиты кишечной микрофлоры в диагностике дисбиоза кишечника. Антибиотики и медицинская биотехнология. 1987; 32 (3): 191–195.Lay C., Rigottier-Gois L., Holmstrom K. et al. Colonic microbiota signatures across five northern Europe countries. Appl. Environ Mibrobiol. 2005; 71(7): 4153–4155.Lay C., Rigottier-Gois L., Holmstrom K. et al. Colonic microbiota signatures across five northern Europe countries. Appl. Environ Mibrobiol. 2005; 71(7): 4153–4155.Zoetendal E.G., Collier C.T., Koike S. et al. Molecular ecological analysis of the gastrointestinal microbiota: a review. J. Nutr. 2004; 134: 465–472.Zoetendal E.G., Collier C.T., Koike S. et al. Molecular ecological analysis of the gastrointestinal microbiota: a review. J. Nutr. 2004; 134: 465–472.Sghir A., Gramet G., Suau A. et al. Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization. Appl. Environ Microbiol. 2000; 66: 2263–2266.Sghir A., Gramet G., Suau A. et al. Quantification of bacterial groups within human fecal flora by oligonucleotide probe hybridization. Appl. Environ Microbiol. 2000; 66: 2263–2266.Franks A.H., Harmsen H.J., Raangs G.C. et al. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group specific 16S rRNA targeted oligonucleotide probes. Appl. Environ Microbiol. 1998; 64: 3336–3345.Franks A.H., Harmsen H.J., Raangs G.C. et al. Variations of bacterial populations in human feces measured by fluorescent in situ hybridization with group specific 16S rRNA targeted oligonucleotide probes. Appl. Environ Microbiol. 1998; 64: 3336–3345.Harmsen H.J., Wildeboer-Veloo A.C., Grijpstra J. et al. Development of 16S rRNA based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl. Environ Microbiol. 2000; 66 (10): 4523–4527.Harmsen H.J., Wildeboer-Veloo A.C., Grijpstra J. et al. Development of 16S rRNA based probes for the Coriobacterium group and the Atopobium cluster and their application for enumeration of Coriobacteriaceae in human feces from volunteers of different age groups. Appl. Environ Microbiol. 2000; 66 (10): 4523–4527.Bourlioux P., Koletzko B., Guarner F., Braesco V. The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium «The Intelligent Intestine» held in Paris. Am. J. Clin. Nutr. 2003; 78: 675–683.Bourlioux P., Koletzko B., Guarner F., Braesco V. The intestine and its microflora are partners for the protection of the host: report on the Danone Symposium «The Intelligent Intestine» held in Paris. Am. J. Clin. Nutr. 2003; 78: 675–683.Seksik P., Rigottier-Gois L., Gramet G. et al. Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon. Gut. 2003; 52: 237–242.Seksik P., Rigottier-Gois L., Gramet G. et al. Alterations of the dominant faecal bacterial groups in patients with Crohn’s disease of the colon. Gut. 2003; 52: 237–242.Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur. J. Clin. Nutr. 1998; 52: 899–907.Spanhaak S., Havenaar R., Schaafsma G. The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur. J. Clin. Nutr. 1998; 52: 899–907.Tannock G.W., Munro K., Harmsen H.J. et al. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl. Environ Microbiol. 2000; 66: 2578–2588.Tannock G.W., Munro K., Harmsen H.J. et al. Analysis of the fecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl. Environ Microbiol. 2000; 66: 2578–2588.Hooper L.V., Wong M.H., Thelin A. et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001; 291: 881–884.Hooper L.V., Wong M.H., Thelin A. et al. Molecular analysis of commensal host-microbial relationships in the intestine. Science. 2001; 291: 881–884.Hooper L.V., Stappenbeck T.S., Hong C.V., Gordon J.I. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 2003; 4: 269–273.Hooper L.V., Stappenbeck T.S., Hong C.V., Gordon J.I. Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol. 2003; 4: 269–273.Stappenbeck T.S., Hooper L.V., Gordon J.I. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc. Natl. Acad. Sci USA. 2002; 99: 15451–15455.Stappenbeck T.S., Hooper L.V., Gordon J.I. Developmental regulation of intestinal angiogenesis by indigenous microbes via Paneth cells. Proc. Natl. Acad. Sci USA. 2002; 99: 15451–15455.Hooper L.V., Midtvedt T., Gordon J.I. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Ann. Rev. Nutr. 2002; 22: 283–307.Hooper L.V., Midtvedt T., Gordon J.I. How host-microbial interactions shape the nutrient environment of the mammalian intestine. Ann. Rev. Nutr. 2002; 22: 283–307.Lecuit M., Nelson D.M., Smith S.D. et al. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. Proc. Natl. Acad. Sci USA. 2004; 101(16): 6152–6157.Lecuit M., Nelson D.M., Smith S.D. et al. Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin. Proc. Natl. Acad. Sci USA. 2004; 101(16): 6152–6157.Walker W.A., Goulet O., Morelli L., Antoin J.M. Progress in the science of probiotics: from cellular microbiology and applied immunology to clinical nutrition. Eur. J. of Nutrition. 2006; 45: 1–18.Walker W.A., Goulet O., Morelli L., Antoin J.M. Progress in the science of probiotics: from cellular microbiology and applied immunology to clinical nutrition. Eur. J. of Nutrition. 2006; 45: 1–18.Oozeer R., Mater D.D., Goupil-Feuillerat N., Corthier G. Initiation of protein synthesis by a labeled derivative of the Lactobacillus casei DN–114001 strain during transit from the stomach to the cecum in mice harboring human microbiota. Appl. Environ Microbiol. 2004; 70: 6992–6997.Oozeer R., Mater D.D., Goupil-Feuillerat N., Corthier G. Initiation of protein synthesis by a labeled derivative of the Lactobacillus casei DN–114001 strain during transit from the stomach to the cecum in mice harboring human microbiota. Appl. Environ Microbiol. 2004; 70: 6992–6997.Oozeer R., Goupil-Feuillerat N., Alpert C.A. et al. Lactobacillus casei is able to survive and initiate protein synthesis during its transit in the digestive tract of human flora-associated mice. Appl. Environ Microbiol. 2002; 68: 3570–3574.Oozeer R., Goupil-Feuillerat N., Alpert C.A. et al. Lactobacillus casei is able to survive and initiate protein synthesis during its transit in the digestive tract of human flora-associated mice. Appl. Environ Microbiol. 2002; 68: 3570–3574.Oozeer R., Furet J.P., Goupil-Feuillerat N. et al. Differential activities of four Lactobacillus casei promoters during bacterial transit through the gastrointestinal tracts of human-microbiota-associated mice. Appl. Environ Microbiol. 2005; 71: 1356–1363.Oozeer R., Furet J.P., Goupil-Feuillerat N. et al. Differential activities of four Lactobacillus casei promoters during bacterial transit through the gastrointestinal tracts of human-microbiota-associated mice. Appl. Environ Microbiol. 2005; 71: 1356–1363.Otte J.M., Podolsky D.K. Functional modulation of enterocytes by grampositive and gram-negative microorganisms. Am. J. Physiol. Gastrointest. 2004; 286: 613–626.Otte J.M., Podolsky D.K. Functional modulation of enterocytes by grampositive and gram-negative microorganisms. Am. J. Physiol. Gastrointest. 2004; 286: 613–626.Бабин В.Н., Минушкин О.Н., Дубинина А.В. Молекулярные основы симбиоза в системе «хозяин – микрофлора». Российский журнал гастроэнтерологии и гепатологии. 1998, 6: 76–82.Бабин В.Н., Минушкин О.Н., Дубинина А.В. Молекулярные основы симбиоза в системе «хозяин – микрофлора». Российский журнал гастроэнтерологии и гепатологии. 1998, 6: 76–82.Karen M. Pickard PhD, A. Ronald Bremner MBCLB, MRCPCH, John N. Gordon MBBS, MRCP and Thomas T. MacDonald Ph.D. Immune responses.Karen M. Pickard PhD, A. Ronald Bremner MBCLB, MRCPCH, John N. Gordon MBBS, MRCP and Thomas T. MacDonald Ph.D. Immune responses.Walker W.A. Mechanisms of Action of Probiotics. Clinical Infectious Diseases. 2008; 46: 87–91.Walker W.A. Mechanisms of Action of Probiotics. Clinical Infectious Diseases. 2008; 46: 87–91.Claud E.C., Savidge T., Walker W.A. Modulation of human intestinal epithelial cell IL 8 secretion by human milk factors. Pediatr. Res. 2003; 53: 419–425.Claud E.C., Savidge T., Walker W.A. Modulation of human intestinal epithelial cell IL 8 secretion by human milk factors. Pediatr. Res. 2003; 53: 419–425.Nanthakumar N.N., Fusunyan R.D., Sanderson I. et al. Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis. Proc. Natl. Acad. Sci USA. 2000; 97: 6043–6048.Nanthakumar N.N., Fusunyan R.D., Sanderson I. et al. Inflammation in the developing human intestine: a possible pathophysiologic contribution to necrotizing enterocolitis. Proc. Natl. Acad. Sci USA. 2000; 97: 6043–6048.Jilling T., Simon D., Lu J. et al. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J. Immunol. 2006; 177: 3273–3282.Jilling T., Simon D., Lu J. et al. The roles of bacteria and TLR4 in rat and murine models of necrotizing enterocolitis. J. Immunol. 2006; 177: 3273–3282.Meydani S.N., Ha W.K. Immunologic effects of yogurt. Am. J. Clin. Nutr. 2000; 71: 861–872.Meydani S.N., Ha W.K. Immunologic effects of yogurt. Am. J. Clin. Nutr. 2000; 71: 861–872.Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F. et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004; 118: 229–241.Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F. et al. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell. 2004; 118: 229–241.Madsen K., Cornish A., Soper P. et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001; 121: 580–591.Madsen K., Cornish A., Soper P. et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology. 2001; 121: 580–591.Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology. 2004; 127: 224–238.Cario E., Gerken G., Podolsky D.K. Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C. Gastroenterology. 2004; 127: 224–238.Yan F., Polk D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem. 2002; 277: 50959–50965.Yan F., Polk D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem. 2002; 277: 50959–50965.Ma D., Forsythe P., Bienenstock J. Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect. Immun. 2004; 72: 5308–5314.Ma D., Forsythe P., Bienenstock J. Live Lactobacillus reuteri is essential for the inhibitory effect on tumor necrosis factor alpha-induced interleukin-8 expression. Infect. Immun. 2004; 72: 5308–5314.Shi H.N., Walker W.A. Bacterial colonization and the development of intestinal defenses. Can. J. Gastroenterol. 2004; 18: 493–500.Shi H.N., Walker W.A. Bacterial colonization and the development of intestinal defenses. Can. J. Gastroenterol. 2004; 18: 493–500.Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001; 2: 675–680.Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2001; 2: 675–680.Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 2004; 303: 1662–1665.Macpherson A.J., Uhr T. Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science. 2004; 303: 1662–1665.Kalliomaki M.A., Walker W.A. Physiologic and pathologic interactions of bacteria with gastrointestinal epithelium. Gastroenterol. Clin. North Am. 2005; 34: 383–399.Kalliomaki M.A., Walker W.A. Physiologic and pathologic interactions of bacteria with gastrointestinal epithelium. Gastroenterol. Clin. North Am. 2005; 34: 383–399.Sudo N., Sawamura S., Tanaka Y., et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 1997; 159:1739–1745.Sudo N., Sawamura S., Tanaka Y., et al. The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J. Immunol. 1997; 159:1739–1745.Malin R. Karlsson, Jarle Rugtveit, Per Brandtzaeg. Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy. J. Exp. Med. 2004; 21; 199 (12): 1679–1688.Malin R. Karlsson, Jarle Rugtveit, Per Brandtzaeg. Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy. J. Exp. Med. 2004; 21; 199 (12): 1679–1688.Spiekermann G., Walker W.A. Oral tolerance and its role in clinical disease. J. Pediatr. Gastroenterol. Nutr. 2001; 32: 237–255.Spiekermann G., Walker W.A. Oral tolerance and its role in clinical disease. J. Pediatr. Gastroenterol. Nutr. 2001; 32: 237–255.Bashir M., Louie S., Shi H., Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 2004; 172: 6978–6987.Bashir M., Louie S., Shi H., Nagler-Anderson C. Toll-like receptor 4 signaling by intestinal microbes influences susceptibility to food allergy. J. Immunol. 2004; 172: 6978–6987.Braat H., van den Brande J., van Tol E., Hommes D. et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am. J. Clin. Nutr. 2004; 80: 1618–1625.Braat H., van den Brande J., van Tol E., Hommes D. et al. Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am. J. Clin. Nutr. 2004; 80: 1618–1625.Adolfsson O., Meydani S.N., Russell R.M. Yogurt and gut function. Am. J. Clin. Nutr. 2004; 80: 245–256.Adolfsson O., Meydani S.N., Russell R.M. Yogurt and gut function. Am. J. Clin. Nutr. 2004; 80: 245–256.Piaia M., Antoine J.M., Mateos-Guardia J.A. et al. Assessment of the benefits of live yogurt: methods and markers for in vivo studies of the physiological effects of yogurt cultures. Microb. Ecol. Health. Dis. 2003; 15: 79–87.Piaia M., Antoine J.M., Mateos-Guardia J.A. et al. Assessment of the benefits of live yogurt: methods and markers for in vivo studies of the physiological effects of yogurt cultures. Microb. Ecol. Health. Dis. 2003; 15: 79–87.Brownlee I.A., Havler M.E., Dettmar P.W. et al. Colonic mucus: secretion and turnover in relation to dietary fibre intake. Proc. Nutr. Soc. 2003; 62:245–249.Brownlee I.A., Havler M.E., Dettmar P.W. et al. Colonic mucus: secretion and turnover in relation to dietary fibre intake. Proc. Nutr. Soc. 2003; 62:245–249.D’Souza A.L., Rajkumar C., Cooke J., Bulpitt C.J. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002; 324:1361.D’Souza A.L., Rajkumar C., Cooke J., Bulpitt C.J. Probiotics in prevention of antibiotic associated diarrhoea: meta-analysis. BMJ. 2002; 324:1361.Gatakka T., Savilahti E., Ponca А. et al. Оthers Influence of the long use fermented milk product on infections amongst children, visiting preschool scholastic institutions: randomized, double blind, placebo controlled. BMJ. 2001; 322: 1327–1329.Gatakka T., Savilahti E., Ponca А. et al. Оthers Influence of the long use fermented milk product on infections amongst children, visiting preschool scholastic institutions: randomized, double blind, placebo controlled. BMJ. 2001; 322: 1327–1329.Hojsak I., Abdović S., Szajewska H. et al. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics. 2010; 125 (5): 1171–1177.Hojsak I., Abdović S., Szajewska H. et al. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics. 2010; 125 (5): 1171–1177.Juntunen M., Kirjavainen P.V., Ouwehand A.C. et al. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin. Diagn. Lab. Immunol. 2001; 8 (2): 293-296.Juntunen M., Kirjavainen P.V., Ouwehand A.C. et al. Adherence of probiotic bacteria to human intestinal mucus in healthy infants and during rotavirus infection. Clin. Diagn. Lab. Immunol. 2001; 8 (2): 293-296.Rautava С., Saliman С., Izolauri E. The Role specific probaiotic in reduction of the risk of the development to sharp infection amongst infant – casual controlled randomized, double-blind, placebo-controlled by method. Br. J. Nutr. 2009; 101: 1722–1726.Rautava С., Saliman С., Izolauri E. The Role specific probaiotic in reduction of the risk of the development to sharp infection amongst infant – casual controlled randomized, double-blind, placebo-controlled by method. Br. J. Nutr. 2009; 101: 1722–1726.Gatakka T., Blomgren T., Rohiyavuori С. et al. Treatment sharp average otitic by means of probaiotics beside childrens, predisposed to otitic, within the framework of double blind placebo controlled trial. Clin. Nutr. 2007; 26: 314–321.Gatakka T., Blomgren T., Rohiyavuori С. et al. Treatment sharp average otitic by means of probaiotics beside childrens, predisposed to otitic, within the framework of double blind placebo controlled trial. Clin. Nutr. 2007; 26: 314–321.Kukkonen T., Savilahti E., Haahtela T. et al. Poussa T and others Long safety and influence on level of the spreading to infections at постнатальном treatment probiotic and prebiotic preparation, double blind placebo controlled trial. Pediatrics. 2008; 122: 8–12.Kukkonen T., Savilahti E., Haahtela T. et al. Poussa T and others Long safety and influence on level of the spreading to infections at постнатальном treatment probiotic and prebiotic preparation, double blind placebo controlled trial. Pediatrics. 2008; 122: 8–12.Kaila M., Isolauri E., Soppi E. et al. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr. Res. 1992; 32 (2): 141–144.Kaila M., Isolauri E., Soppi E. et al. Enhancement of the circulating antibody secreting cell response in human diarrhea by a human Lactobacillus strain. Pediatr. Res. 1992; 32 (2): 141–144.Izolauri E., Yoensuu D., Suomalaynen H. et al. Perfected иммуногенность пероральной ротавирусной vaccines реассортанта D x RRV under influence Lactobacillus rhamnosus GG Vaccine. 1995; 13: 310.Izolauri E., Yoensuu D., Suomalaynen H. et al. Perfected иммуногенность пероральной ротавирусной vaccines реассортанта D x RRV under influence Lactobacillus rhamnosus GG Vaccine. 1995; 13: 310.Заболеваемость населения Российской Федерации. Здоровье населения и среда обитания. 2007; 1 (166): 50–51.Заболеваемость населения Российской Федерации. Здоровье населения и среда обитания. 2007; 1 (166): 50–51.
The authors declare that there are no conflicts of interest present.