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Experience of the Successful Treatment With Canakinumab of a Patient With Systemic Juvenile Idiopathic Arthritis

https://doi.org/10.15690/vsp.v16i2.1719

Abstract

The article presents the follow-up of a patient with severe systemic juvenile idiopathic arthritis (JIA) resistant to glucocorticosteroids, to the first genetically engineered biologic drug (GEBD) tocilizumab, a monoclonal antibody to the interleukin (IL) 6 receptor. Switching to the second GEBD — a monoclonal antibody to IL1β canakinumab — provided a remission of the disease. The first injection of the drug fully arrested the systemic symptoms of the disease, and the fourth one — the articular syndrome. The presented clinical example shows that switching to GEBD with a different mechanism of action — a monoclonal antibody to IL1β canakinumab — is highly effective and induces a remission of the disease in patients with systemic JIA resistant to tocilizumab. There were no adverse events under pressure of canakinumab therapy.

About the Authors

Ekaterina I. Alexeeva
National Scientific and Practical Center of Children’s Health; Sechenov First Moscow State Medical University
Russian Federation


Olga L. Lomakina
National Scientific and Practical Center of Children’s Health
Russian Federation


Tatiana M. Bzarova
National Scientific and Practical Center of Children’s Health; Sechenov First Moscow State Medical University
Russian Federation


References

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Review

For citations:


Alexeeva E.I., Lomakina O.L., Bzarova T.M. Experience of the Successful Treatment With Canakinumab of a Patient With Systemic Juvenile Idiopathic Arthritis. Current Pediatrics. 2017;16(2):170-174. (In Russ.) https://doi.org/10.15690/vsp.v16i2.1719

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ISSN 1682-5527 (Print)
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