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Вопросы современной педиатрии

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Генетические аспекты неалкогольной жировой болезни печени

https://doi.org/10.15690/vsp.v17i6.1974

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Аннотация

Неалкогольная жировая болезнь печени (НАЖБП) является наиболее часто диагностируемой патологией этого органа. Наблюдается увеличение доли случаев НАЖБП в структуре заболеваний печени у детей и подростков, что напрямую связано с ростом распространенности ожирения. Спектр изменений печеночной ткани при НАЖБП варьирует от доброкачественного стеатоза гепатоцитов до неалкогольного стеатогепатита, фиброза, цирроза печени и гепатоцеллюлярной карциномы. С ростом распространенности НАЖБП у детей мы можем ожидать увеличение числа случаев неблагоприятных исходов среди лиц трудоспособного возраста. Ключевой проблемой НАЖБП остается прогнозирование исходов заболевания. В эпидемиологических и генетических исследованиях показана связь морфологической стадии НАЖБП и наследственных факторов. В настоящее время выделяют три гена, ассоциированных с НАЖБП (PNPLA3, TM6SF2 и GCKR), которые вместе с генами, отвечающими за инсулинорезистентность, депонирование липидов, воспаление и фиброгенез в гепатоцитах, определяют фенотип жировой болезни печени. Предложено современное понимание вопросов генетики, развития стеатоза печени и прогрессирования неалкогольного стеатогепатита. Ожидается, что эти знания могут трансформировать наши стратегии по стратификации риска у пациентов с НАЖБП и способствовать выявлению новых терапевтических целей.

Об авторах

П. О. Богомолов
Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского
Россия

кандидат медицинских наук, заведующий гепатологическим отделом

129110, Москва, ул. Щепкина, д. 61/2, кор. 1,

+7 (499) 674-07-09,



К. Ю. Кокина
Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского
Россия


А. Ю. Майоров
Национальный медицинский исследовательский центр эндокринологии
Россия


Е. Е. Мишина
Национальный медицинский исследовательский центр эндокринологии
Россия


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Для цитирования:


Богомолов П.О., Кокина К.Ю., Майоров А.Ю., Мишина Е.Е. Генетические аспекты неалкогольной жировой болезни печени. Вопросы современной педиатрии. 2018;17(6):442-448. https://doi.org/10.15690/vsp.v17i6.1974

For citation:


Bogomolov P.O., Kokina K.Y., Mayorov A.Y., Mishina E.E. Genetic Aspects of Non-Alcoholic Fatty Liver Disease. Current Pediatrics. 2018;17(6):442-448. (In Russ.) https://doi.org/10.15690/vsp.v17i6.1974

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