О ДОЗИРОВАНИИ ВИТАМИНА D У ДЕТЕЙ И ПОДРОСТКОВ
https://doi.org/10.15690/vsp.v14i1.1261
Аннотация
Данные современных фундаментальных и клинических исследований демонстрируют, что повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей (400–500 МЕ/сут) существенно занижены. В статье представлены результаты обзорных и клинических исследований (n =21), в которых зафиксирована положительная динамика концентрации 25(OH)D в плазме крови на фоне применения витамина D у детей и подростков в возрасте от 0 до 18 лет. Продолжительность приема витамина D в проанализированных исследованиях составила от 1 до 12 мес, доза — от 800 до 4000 МЕ/сут. По результатам повозрастного анализа предложена ступенчатая схема назначения витамина D: для детей в возрасте до 4 мес рекомендуется ежедневный прием 500 МЕ/сут (для недоношенных — 800–1000 МЕ/сут), в возрасте от 4 мес до 4 лет — 1000 МЕ/сут, 4–10 лет — 1500 МЕ/сут, 10–16 лет — 2000 МЕ/сут витамина в течение года. При этом достигается эффективная компенсация дефицита витамина D (концентрация 25(OH)D >20 нг/мл), а также, по некоторым данным, снижение риска развития инфекционных и аллергических заболеваний. Показана безопасность рекомендуемого режима приема витамина D.
Об авторах
О. А. ГромоваРоссия
доктор медицинских наук, профессор кафедры фармакологии и клинической фармакологии ИвГМА, научный консультант Российского сотрудничающего центра «Нейробиология» института микроэлементов ЮНЕСКО
И. Ю. Торшин
Россия
И. Н. Захарова
Россия
В. Б. Спиричев
Россия
О. А. Лиманова
Россия
Т. Э. Боровик
Россия
Г. В. Яцык
Россия
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Рецензия
Для цитирования:
Громова О.А., Торшин И.Ю., Захарова И.Н., Спиричев В.Б., Лиманова О.А., Боровик Т.Э., Яцык Г.В. О ДОЗИРОВАНИИ ВИТАМИНА D У ДЕТЕЙ И ПОДРОСТКОВ. Вопросы современной педиатрии. 2015;14(1):38-47. https://doi.org/10.15690/vsp.v14i1.1261
For citation:
Gromova O.A., Torshin I.Yu., Zakharova I.N., Spirichev V.B., Limanova O.A., Borovik T.E., Yatsyk G.V. DOSAGE OF VITAMIN D IN CHILDREN AND ADOLESCENTS. Current Pediatrics. 2015;14(1):38-47. (In Russ.) https://doi.org/10.15690/vsp.v14i1.1261