О ДОЗИРОВАНИИ ВИТАМИНА D У ДЕТЕЙ И ПОДРОСТКОВ

Данные современных фундаментальных и клинических исследований демонстрируют, что повсеместно используемые нормы рекомендованного суточного потребления витамина D для детей (400–500 МЕ/сут) существенно занижены. В статье представлены результаты обзорных и клинических исследований (n =21), в которых зафиксирована положительная динамика концентрации 25(OH)D в плазме крови на фоне применения витамина D у детей и подростков в возрасте от 0 до 18 лет. Продолжительность приема витамина D в проанализированных исследованиях составила от 1 до 12 мес, доза — от 800 до 4000 МЕ/сут. По результатам повозрастного анализа предложена ступенчатая схема назначения витамина D: для детей в возрасте до 4 мес рекомендуется ежедневный прием 500 МЕ/сут (для недоношенных — 800–1000 МЕ/сут), в возрасте от 4 мес до 4 лет — 1000 МЕ/сут, 4–10 лет — 1500 МЕ/сут, 10–16 лет — 2000 МЕ/сут витамина в течение года. При этом достигается эффективная компенсация дефицита витамина D (концентрация 25(OH)D >20 нг/мл), а также, по некоторым данным, снижение риска развития инфекционных и аллергических заболеваний. Показана безопасность рекомендуемого режима приема витамина D.

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