Preview

Current Pediatrics

Advanced search

ESOMEPRAZOLE EFFICACY IN TREATMENT OF THE INFLAMMATORY DISEASES OF THE UPPER GASTROINTESTINAL TRACT AMONG CHILDREN, SUFFERING FROM RHEUMATIC DISEASES

Abstract

The article deals with the findings of the endoscopic examination and treatment of 80 children, suffering from rheumatic diseases. According to the esophago gastroduodenoscopy data, all the patients turned up to have inflammatory changes in the upper gastrointestinal tract of various degrees of manifestation. Moreover, only 36% of patients complained about pain in the stomach. The application of esomeprazole in the complex therapy contributed to the epithelization of erosive and ulcerous defects and dyspepsia syndrome relief among the majority of the patients. The effects of the complex therapy with esomeprazole were appraised as good among 90% of children and excellent among 9% of patients.
Key words: children, rheumatic diseases, esomeprazole, gastrointestinal tract pathology.

About the Authors

E.I. Alexeeva
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


E.G. Chistyakova
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


M.M. Lokhmatov
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


T.M. Bzarova
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


References

1. Шахбазян И.Е., Жолобова Е.С., Чистякова Е.Г., Мелешкина А.В. Частота поражения верхних отделов желудочно-кишечного тракта у больных с системными формами ювенильного ревматоидного артрита в зависимости от проводимой терапии. Материал научно-практической конференции педиатров России «Фармакотерапия в педиатрии». М. 2003. 91 с.

2. Шахбазян И.Е., Климанская Е.В., Жолобова Е.С., Мелешкина А.В., Таберовская Е.М., Новикова А.В. Роль различных факторов в развитии патологии верхних отделов желудочно-кишечного тракта при хронических артритах у детей. Российский педиатрический журнал. 2003; 3: 37–40.

3. Бзарова Т.М., Щербаков П.Л., Алексеева Е.И. и соавт. Лечение патологии верхних отделов желудочноCкишечного тракта у детей с ревматическими болезнями. Вопросы совр. педиатр. 2006; 5 (5) (прил.): 33–38.

4. James T. Cassidy, Ross E. Petty. Textbook of Pediatric Rheumatology. 4th edition. 2001. Р. 218–321.

5. Lanas A., Arroyo M. Antisecretory drags and prophylaxis of secondary gastrointestynal effects associated with the consumption of non–steroid anti–inflammatory drags. Med. Clin. 2000; 114 (Suppl. 2): 57–62.

6. Yeomas N., Scheiman J., Hawkey C. et al. An evidence based analysis of esomeprasole therapy versus placebo for the prevention of gastric or duodenal ulcers in at risk continuous NSAID users. Gastroenterology. 2004; 126 (4 Suppl. 2): 338.

7. Ruperto N., Nikishina I., Pachanov E., Shachbazian Y. et al. A Randomized Double blind clinical trial of two doses of Mеloxicam compared with naproxen in children with JRA. Arthr. Rheum. 2005; 52: 563–572.

8. Алексеева Е.И., Шахбазян И.В. Ювенильный ревматоидный артрит. Кардиология и ревматология детского возраста. Под ред. Г.А. Самсыгиной, М.Ю.Щербаковой. М. 2004. С. 47–54.

9. Oshima H. Mechanisms of the molecular action of glucocorticoids. Jap. J. Rheumat. 1997; 7: 1–12.

10. Morand E. Corticosteroids in the treatment of rheumatologic diseases. Curr. Opin.Rheum. 1997; 9: 200–205.

11. Насонова В.А., Бунчук Н.В. Ревматические болезни. Руководство по внутренним болезням. М.: Медицина. 1997. С. 298–299.

12. Шахбазян И.Е., Гаркуша М.Б., Али Н.Ю. и др. Гастродуоденит и Helicobacter pylori у детей, больных ювенильным ревматоидным артритом. Ревматология. 1991; 3: 23–28.


Review

For citations:


Alexeeva E., Chistyakova E., Lokhmatov M., Bzarova T. ESOMEPRAZOLE EFFICACY IN TREATMENT OF THE INFLAMMATORY DISEASES OF THE UPPER GASTROINTESTINAL TRACT AMONG CHILDREN, SUFFERING FROM RHEUMATIC DISEASES. Current Pediatrics. 2007;6(1):105-107.

Views: 525


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)