Preview

Current Pediatrics

Advanced search

MODERN PREBIOTICS IN CORRECTION OF INTESTINAL MICROBIOCENOSIS IN CHILDREN

Abstract

This article presents a data of role of normal micro flora of gastrointestinal tract in forming of alimentary functions and immune system of newborn. Processes of formation of intestinal micro biocenose, and pre and postnatal factors of development of dysbacteriosis in children of early age were analyzed. Authors give modern classification of probiotics. Results of trials show effectiveness and safety of combination of probiotiс cultures Bifidobacterium lactis BB-12 and Streptococcus thermophilus, forming new complex «Bifiform Baby» for children of early age.
Key words: children of early age, normal micro flora, gastrointestinal tract, probiotics.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(2):109-113)

About the Authors

I.N. Zakharova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation


L.N. Mazankova
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation


Yu.A. Dmitrieva
Russian Medical Academy of Postgraduate Education, Moscow
Russian Federation


References

1. Микрофлора пищеварительного тракта. Под ред. А.И. Хавкина. М.: Фонд социальной педиатрии. 2007. 119 с.

2. Мазанкова Л.Н., Шевелева С.А., Лыкова Е.А. Клиническое применение пробиотиков: систематизация препаратов и тактика назначения в детском возрасте. Пособие для врачей. М. 2005. 27 с.

3. Bayston R., Leung T.S., Spitz I. Faecal flora in neonates with oesophageal atresia. Arch. Dis. Child. 1984; 59 (2): 126–130.

4. Лыкина Е.В. Влияние искусственного вскармливания на состояние желудочно–кишечного тракта у детей первого года жизни. Автореф. дис… к.м.н. М. 2007. 24 с.

5. Секреты гастроэнтерологии. Под ред. П.М. Мак Нелли. М. 1999. 673 с.

6. Van Niel C.W. Probiotics: not just for treatment anymore. Pediatrics. 2005; 115 (1): 174–177.

7. Salminen S., Benno Y., de Vos W. Intestinal colonisation, microbiota and future probiotics? Asia Pac. J. Clin. Nutr. 2006; 15 (4): 558–562.

8. Saavedra J.M., Bauman N.A., Oung I. et. al. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhoea and shedding of rotavirus. Lancet. 1994; 344 (8929): 1046–1049.

9. Chouraqui J.P., Grathwohl D., Labaune J.M. et al. Assessment of the safety, tolerance, and protective effect against diarrhea of infant formulas containing mixtures of probiotics or probiotics and prebiotics in a randomized controlled trial. Am. J. Clin. Nutr. 2008; 87 (5): 1365–1373.

10. Bullen C.L., Willis A.T. Resistance of the breast-fed infant to gastroenteritis. Br. Med. J. 1971; 3: 338–343.

11. Howie P.W., Forsyth J.S., Ogston S.A. et al. Protective effect of breast feeding against infection. BMJ. 1990; 300 (6716): 11–16.

12. Benno Y., Sawada K., Mitsooka T. The intestinal microflora of infants; composition of fecal flora in breast fed and bottle fed infants. Microbiol. Immunol. 1984; 28 (9): 975–986.

13. Duffy L.C., Riepenhoff–Talty M., Ryers Т.Е. et al. Modulation of rotavirus enteritis during breast feeding. Am. J. Dis. Child. 1986; 140 (11): 1164–1168.

14. Hotra M., Salo Y., Iwala S. et al. Clinical effects of bifidobacterium preparations on pediatric intractable diarrhea. Keio J. Med. 1987; 36 (3): 298–314.

15. Fukushima Y., Li S.T., Hara H. et al. Effect of follow up formula containing bifidobacteria (Nan BF) on fecal flora and fecal metabolites in healthy children. Bioscience Microflora. 1997; 16: 65–72.

16. Saavedra J.M. Microbes to fight microbes: a not so novel approach to controlling diarrheal disease. J. Pediatr. Gastroenteral. Nutr. 1995; 21 (2): 125–129.

17. Fukushima Y., Kawata Y., Hara H. et al. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int. J. Food Microbiol. 1998; 42: 39–44.

18. Link-Amster H., Rochat F., Saudan K.Y. et al. Modulation of a specific humoral immune response and change in intestinal flora mediated through fermented milk in take. FEMS Immunol. Med. Microbiol. 1994; 10: 55–64.

19. Shiffrin E.J., Roechar F., Link-Amster H. et al. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J. Dairy Sci. 1995; 78 (3): 491–497.

20. Agency response letter GRAS Notice No GRN 000049, U.S. Food and Drug Administration Center for Food Safety and Applied Nutrition Office of Food Additive Safety, March 10, 2002. Доступно на: http://www.cfsan.fda.gov/

21. Saavedra J.M., Abi-Hanna A., Moore N. Long term consumption of infant formulas containing life probiotic bacteria: tolerance and safety. Am. J. Clin. Nutr. 2004; 79: 261–267.

22. Sakata H., Yoshioka H., Fujita K. Development of the inlestinaj flora in very low birthweighr infants compared to normal full-term newborns. Eur. J. Ped. 1985; 114: 186-190.

23. Blakely J.L., Lubitz L., Barnes G.L. et al. Development of gut colonisation in preterm neonates. J. Med. Microbiol. 1982; 15: 519-529.

24. Gewolb I.H., Schwalbe R.S., Taciak V.L. et al. Stool microflora in extremely low birth weight infants. Arch. Dis. Child. Fetal. Neonatal. 1999; 80 (3): 167–173.

25. Bin-Nun A., Bromiker R., Wilschanski M. et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J. Pediatr. 2005; 147 (2): 192–196.

26. Mohan R., Koebnick C., Schildt J. et al. Effects of Bifidobacterium lactis Bb12 supplementation on body weight, fecal pH, acetate, lactate, calprotectin and IgA in preterm infants. Pediatr. Res. 2008; 64 (4): 418–422.


Review

For citations:


Zakharova I., Mazankova L., Dmitrieva Yu. MODERN PREBIOTICS IN CORRECTION OF INTESTINAL MICROBIOCENOSIS IN CHILDREN. Current Pediatrics. 2009;8(2):109-113.

Views: 750


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)