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THERAPEUTIC OPPORTUNITIES OF FUNCTIONAL COMPOUND, CONTAINING LACTULOSE, IN INFANTS UNDER FIRST YEAR OF LIFE WITH INFECTIONAL ENTEROCOLITIS AND INTESTINAL DISBIOSIS

Abstract

This trial studied effectiveness of prebiotic dose of lactulose in 200–400 ml of milk compound «Bifidus», in nutrition of infants under first year old, hospitalized with inflectional enterocolitis. Catamnestic observation of patients with diagnostics of faecal microflora showed increase of rate (on 29%) of durable stool normalization in children, whose nutrition contained of «Bifidus» compound during 1–1.5 months, compared to children, receiving compounds without prebiotic substances (p = 0.048). Besides, statistically significant increase of obligate populations of microbes in intestine of children, receiving breast feeding or lactulose-containing compound was detected. Such changes were revealed on the basis of stopping the symptoms of intestinal inflammatory process. Children, receiving compound with lactulose, showed restoration of micro biocenosis and decrease of rate of proliferation of opportunistic gram-negative pathogens.
Key words: children under first year old, inflectional enterocolitis, intestinal microflora, lactulose.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(4):63-71)

About the Authors

E.R. Meskina
M.F. Vladimirskiy Moscow Regional Scientific Clinical Institute
Russian Federation


L.V. Feklistova
M.F. Vladimirskiy Moscow Regional Scientific Clinical Institute
Russian Federation


A.Yu. Ushakova
M.F. Vladimirskiy Moscow Regional Scientific Clinical Institute
Russian Federation


L.V. Pozhalostina
M.F. Vladimirskiy Moscow Regional Scientific Clinical Institute
Russian Federation


E.I. Likhanskaya
M.F. Vladimirskiy Moscow Regional Scientific Clinical Institute
Russian Federation


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Review

For citations:


Meskina E., Feklistova L., Ushakova A., Pozhalostina L., Likhanskaya E. THERAPEUTIC OPPORTUNITIES OF FUNCTIONAL COMPOUND, CONTAINING LACTULOSE, IN INFANTS UNDER FIRST YEAR OF LIFE WITH INFECTIONAL ENTEROCOLITIS AND INTESTINAL DISBIOSIS. Current Pediatrics. 2009;8(4):63-71.

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