NEW DATA ON INFLUENCE OF PREBIOTICS ON MORBIDITY OF INFANTS
Abstract
The article presents new data on positive effect of prebiotical complex on immune system. The decrease of mortality with as intestinal infections, as infections of upper airways was shown on the basis of nutrition with milk compound, fortified with prebiotics.
Key words: infants, adapted milk compounds, prebiotics, immunity, infections.
(Voprosy sovremennoi pediatrii — Current Pediatrics. 2009;8(6):117-122)
References
1. Howie P., Forsyth J., Ogston S. et al. Protective effect of breast feeding against infection. Br. Med. J. 1990; 300: 11–16.
2. Kunz C., Rudloff S., Baier W. et al Oligosaccharides in human milk: structural, functional and metabolic aspects. Annu. Rev. Nutr. 2000; 20: 699–722.
3. Newburg D. Oligosaccharides in human milk and bacterial colonization. J. Pediatr. Gastroenterol. Nutr. 2000; 30: 8–17.
4. Orrhage K., Nord C. Factors controlling the bacterial colonization of the intestine in breast fed infants. Acta Paediatr. 1999; 88 (Suppl. 430): 47–57.
5. Gibson G., Roberfroid M. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J. Nutr. 1995; 125: 1401–1412.
6. Boehm G., Stahl B. Oligosaccharides. In: Mattila-Sandholm T, editor. Functional dairy products. Cambridge: Woodhead Publ. 2003. P. 203–243.
7. Boehm G., Lidestri M., Casetta P. et al. Supplementation of a bovine milk formula with an oligosaccharide mixture increases counts of fecal bifidobacteria in preterm infants. Arch. Dis. Child Fetal Neonatal Ed. 2002; 86: 178–181.
8. Moro G., Minoli I., Mosca M.et al. Dosage related bifidogenic effects of galacto- and fructo–oligosaccharides in formula fed term infants. J. Pediatr. Gastroenterol. Nutr. 2002; 34: P. 291–295.
9. Knol J., Scholtens P., Kafka C. et al. Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breast-fed infants. J. Pediatr. Gastroenterol. Nutr. 2005; 40: 36–42.
10. Harmsen H., Wildeboer–Veloo A., Raangs G. et al. Analysis of intestinal flora development in breast-fed and formula fed infants by using molecular identification and detection methods. J. Pediatr. Gastroenterol. Nutr. 2000; 30: 61–67.
11. Ouwehand A., Isolauri E., Salminen S. The role of the intestinal microflora for the development of the immune system in early childhood. Eur. J. Nutr. 2002; 41 (Suppl. 1): 132–137.
12. Björkstén B., Sepp E., Julge K. et. al. Allergy development and the intestinal microflora during the first year of life. J. Allergy. Clin. Immunol. 2001; 108: 516–520.
13. Kohler H., McCormick B., Walker W. Bacterial enterocyte crosstalk: cellular mechanisms in health and disease. J. Pediatr. Gastroenterol. Nutr. 2003; 36: 175–185.
14. Bruzzese E., Volpicelli M., Squeglia V. et al. A formula containing galacto– and fructo–oligosaccharides prevents intestinal and extra-intestinal infections: an observational study. Clin. Nutr. 2009; 28 (2): 156–161.
15. Vesikari T., Van Damme P., Giaquinto C. et al. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition. European Society for Paediatric Infectious Diseases. Evidence based recommendations for rotavirus vaccination in Europe. J. Pediatr. Gastroenterol. Nutr. 2008; 46 (2): 38–48.
16. American Academy of Paediatrics Committee on Infectious Diseases. Prevention of influenza: recommendations for influenza immunization of children 2006–2007. Pediatrics. 2007; 119: 846–851.
17. Moro G., Minoli I., Mosca M. et al. Dosage related bifidogenic effects of galacto– and fructo– oligosaccharides in formula fed term infants. J. Pediatr. Gastroenterol. Nutr. 2002; 34: 291–295.
18. Vos A., Haarman M., Buco A. et al. A specific prebiotic oligosaccharide mixture stimulates delayed type hypersensitivity in a murine influenza vaccination model. Int. Immunopharmacol. 2006; 6: 1277–1286.
19. Vos A., Haarman M., van Ginkel J-W. et al. Dietary supplementation of neutral and acidic oligosaccharides enhances Th1-dependent vaccination responses in mice. Pediatr. Allergy Immunol. 2007; 18: 304–312.
Review
For citations:
Surzhik A. NEW DATA ON INFLUENCE OF PREBIOTICS ON MORBIDITY OF INFANTS. Current Pediatrics. 2009;8(6):117-120.
Email this article 
