Preview

Current Pediatrics

Advanced search

ROLE OF AZITHROMYCIN IN COMPLEX TREATMENT OF RESPIRATORY DISEASES IN CHILDREN

Abstract

The article contains the analysis of the role of azithromycin (sumamed) in treatment of respiratory diseases in children. It is noted that azithromycin is an efficient antibacterial drug for treatment of extramural and uncomplicated pneumonia and is the drug of choice for atypical mycoplasmal and chlamidia trachomatis pneumonia, as well as for relapses of chronic bronchopulmonary diseases in children. High sensitivity to azithromycin of main pneumotropic and atypical agents, convenience of application, presence of children's pharmaceutical forms, reduction of administration to 1 time per day in case of short treatment schedules, high efficiency and absence of serious adverse events make it possible to recommend this antibiotic as an available means for treatment of respiratory diseases in infants and senior children not only as in patients but as out patients as well.
Key words: children, azithromycin, treatment, respiratory diseases.

About the Authors

E.V. Sereda
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


L.K. Katosova
Scientific Center of Children's Health, Russian Academy of Medical Sciences, Moscow
Russian Federation


References

1. Таточенко В.К., Середа Е.В., Федоров А.М. и др. Антибактериальная терапия пневмоний у детей. Антибиотики и химиотерапия. 2000; 45 (5): 33–40.

2. Середа Е.В., Катосова Л.К. Оральные антибактериальные препараты при бронхолегочных заболеваниях у детей. РМЖ. 2001; 9 (16–17): 706–709.

3. Страчунский Л.С., Козлов С.Н. Макролиды в современной клинической практике. Смоленск: Русич. 1998. 302 с.

4. Катосова Л.К., Спичак Т.В., Бобылев В.А. и др. Этиологическое значение Chlamydia pneumoniae у детей с рецидивирующими и хроническими болезнями легких. Вопросы современной педиатрии. 2003; 2 (1): 47–50.

5. Чучалин А.Г., Синопальников А.И., Страчунский Л.С. и др. Инфекционное обострение хронической обструктивной болезни легких. Практические рекомендации по диагностике, лечению, профилактике. Российский медицинский вестник. 2006; 12: 4–18.

6. Козлов С.Н., Рачина С.А., Домникова Н.П. Фармакоэпидемиологический анализ лечения внебольничной пневмонии в амбулаторных условиях. КМАХ. 2000; 2: 74–81.

7. Кашимото К. Место макролидов в педиатрической практике. Материалы Международной конференции «Антибактериальная терапия в педиатрической практике». М. 1999. С. 52–55.

8. Esposito S., Bosis S., Faelli N. et al. Role of atypical bacteria and azythromicin therapy for children with recurrent respiratory tract infections. Pediatr. Infect. Dis. J. 2005; 24 (5): 438–444.

9. Onodera S., Shiba K. Tissue and body fluid concentrations of azythromicin. 3rd JCMAS. Lisbon. 1996. P. 414.

10. Страчунский Л.С., Белоусов Ю.Б., Козлов С.Н. Антибактериальная терапия. М. 2000. 191 с.

11. Azythromicin. Drug Facts and Comparisons. Wolters Kluwer Health Inc. 2005. Р. 14.

12. Ballow C., Amsden G. Azythromicin the first azalide antibiotic. Ann. Pharmacother. 1992; 26 (10): 1253–1261.

13. Woo P., Lau S., Yuen K. Macrolides as immunomodulatory agents. Curr. Med. Chem. 2002; 1: 131–141.

14. Amsden G. Anti–inflammatory effects of macrolides an underappereciated benefit in the treatment of community acquired respiratory tract infections and chronic inflammatory pulmonary conditions? J. Antimicrob. Chemother. 2005; 55 (1): 10–21.

15. Карпов О.И. Макролиды: новая парадигма: фармакодинамика/иммуномодуляция. Клиническая фармакология и терапия 2005; 5: 20–23.

16. Asgrimsson V., Gudjonsson T., Gudmundsson G. et al. Novel Effects of Azythromicin on Tight Junction Proteins in Human Airway Epithelia. Antimicrob. Agents. Chember. 2006; 50 (5): 1805–1812.

17. Mullin J., Agostino N., Rendon-Huerta E. et al. Keynote review: epithelial and endothelial barriers in human disease. Drag. Discow. Today. 2005; 10 (6): 395–408.

18. Keicho N., Kuboh S. Diffuse panbronchiolitis: role of macrolides in therapy. Am. J. Respir. Med. 2002; 1 (2): 119–131.

19. Saiman L., Marshall B., Mayer–Hamblett N. et al. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA. 2003; 290 (13): 1749–1756.

20. Schultz M. Macrolide activities beyond their antimicrobial effects: macrolides in diffuse panbronchiolitis and cystic fibrosis. J. Antimicrob. Chemober. 2004; 54 (1): 21–28.

21. Жарикова Л.П. Азитромицин: что нужно знать педиатру? Фарматека. 2007; 17: 31–37.


Review

For citations:


Sereda E., Katosova L. ROLE OF AZITHROMYCIN IN COMPLEX TREATMENT OF RESPIRATORY DISEASES IN CHILDREN. Current Pediatrics. 2008;7(1):105-110.

Views: 572


ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)