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REVIEW OF SAFETY AND TOLERANCE OF OMALIZUMAB

Abstract

The review of safety of monoclonal anti-ige-antibodies (xolair) — a new medication for the treatment of severe allergic bronchial asthma is presented. Local and system adverse events, originating after injection of medicament in clinical studies and following administration in patients are discussed.
Key words: children, bronchial asthma, monoclonal anti Ige antibodies.

About the Author

A.V. Emel'yanov
St-Petersburg Medical Academy of Postgraduate Education
Russian Federation


References

1. Djukanovich R., Wilson S.J., Kraft M. et al. Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am. J. Respir. Crit. Care Med. 2004; 170 (6): 583–593.

2. Global Initiative for Аsthma. NHLB/WHO Workshop Report. 2007. 103 с.

3. Walker S., Monteil M., Phelan K. et al. Anti–IgE for chronic asthma in adults and children. Cochrane Database Syst. Rev. 2006; 2: CD003559.

4. Deniz Y.M., Gupta N. Safety and tolerability of omalizumab (Xolair), a recombinant humanized monoclonal anti-IgE antibody. Clin. Rev. Allergy Immunol. 2005; 29 (1): 31–48.

5. Cox L., Platt-Mills T., Finegold I. et al. American Academy of Allergy Asthma Immunology/American College of Asthma, Allergy and Immunology Join Task Report on omalizumab associate anaphylaxis. J. Allergy Clin. Immunol. 2007; 120 (7): 1373–1377

6. Giavina-Banchi P., Giavina-Banchi M., Agondi R. et al. Omalizumab and Churg–Strauss syndrome. J. Allergy Clin. Immunol. 2008; 122 (1): 217.


Review

For citations:


Emel'yanov A. REVIEW OF SAFETY AND TOLERANCE OF OMALIZUMAB. Current Pediatrics. 2008;7(5):87-90.

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ISSN 1682-5527 (Print)
ISSN 1682-5535 (Online)