PREVENTION AND TREATMENT OF ACUTE RESPIRATORY INFECTIONS OF NASAL PHARYNX AMONG THE PATIENTS, SUFFERING FROM JUVENILE ARTHRITIS

Abstract

The research objective is to appraise the effectiveness of topic lysates in prevention and treatment of respiratory infections of nasal pharynx among the patients with juvenile arthritis. The authors have examined 118 children aged between 12 and 16 years old. The main group comprised 68 children with juvenile arthritis without any implications of the acute respiratory infection or within the decubation (in 5–10 days after the acute respiratory infection), who underwent 14bdays course of the medication from the group of topic lysates according to the prevention scheme. The comparison group comprised 20 children with juvenile arthritis, who did not receive any topic immunomodulators. The control group comprised 30 practically healthy children (AVERAGELY AGED 14,8 Ѓ 2,3 YEARS). Before the prescription of the prevention course of topic lysates and in 1 and 3 months after the treatment children underwent clinical and laboratory examination. The research findings showed that the application of the medication from the group of topic lysates among children with juvenile arthritis ensured the reduction of acute respiratory infection growth frequency by 2,3 times and reduction of entinflammatory change implications by 2,2 times (Р < 0,05). The treatment with the bacterial lysate caused the firm reduction of S. аureus and S. saprophyticus sowing for the period of no less than 3 months (Р < 0,05). The firm reduction of sowing was observed in 50% of cases, whereas the normalization of microflora of nasal pharynx was observed among 41% of the patients. The application of local immunomodulators among children led to normalization of Igg and siga indices in the saliva (p < 0,05) for the period of no less than 3 months, which was accompanied by the reduction of acute respiratory infection frequency by 2,3 times, reduction of ent inflammatory change implications by 2,2 times and necessity in the antibacterial therapy if compared with the pervious year by 2,1 times (P < 0,05).
Key words: juvenile arthritis, children, acute respiratory infections, prevention.