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Вопросы современной педиатрии

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Хронический небактериальный («стерильный») остеомиелит в практике детского ревматолога, современные подходы к диагностике и лечению: обзор литературы и анализ собственных данных

https://doi.org/10.15690/vsp.v15i1.1498

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Аннотация

В статье представлены современные данные о патогенезе, особенностях клинических проявлений и диагностике различных вариантов хронического небактериального («стерильного») остеомиелита (ХНО, англ. chronic non-bacterial osteomyelitis, CNO). Приведено описание наследственных форм заболевания, таких как синдромы дефицита антагониста интерлейкина 1 (DIRA), стерильного гнойного артрита в сочетании с гангренозной пиодермией и акне (PAPA-синдром), дизэритропоэтической анемии в сочетании с хроническим небактериальным остеомиелитом (Majeed-синдром). В основе патогенеза ХНО и родственных заболеваний лежит гиперпродукция провоспалительных цитокинов, в частности интерлейкина-1β и фактора некроза опухоли α. Приведены основанные на данных литературы и собственных наблюдениях рекомендации по диагностике и лечению ХНО.

Об авторах

О. Л. Копчак
Санкт-Петербургский государственный педиатрический медицинский университет; Кировская детская областная больница
Россия

Санкт-Петербург;

 врач-ревматолог, 610000, Киров, ул. Менделеева, д. 16



М. М. Костик
Санкт-Петербургский государственный педиатрический медицинский университет
Россия
Санкт-Петербург


А. Ю. Мушкин
Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии
Россия
Санкт-Петербург


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Для цитирования:


Копчак О.Л., Костик М.М., Мушкин А.Ю. Хронический небактериальный («стерильный») остеомиелит в практике детского ревматолога, современные подходы к диагностике и лечению: обзор литературы и анализ собственных данных. Вопросы современной педиатрии. 2016;15(1):33-44. https://doi.org/10.15690/vsp.v15i1.1498

For citation:


Kopchak O.L., Kostik M.M., Mushkin A.Y. Chronic Non-Bacterial («Sterile») Osteomyelitis in the Practice of Pediatric Rheumatologist, the Contemporary Diagnostic and Treatment Approaches: Literature Review and Own Data Analysis. Current Pediatrics. 2016;15(1):33-44. (In Russ.) https://doi.org/10.15690/vsp.v15i1.1498

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