Muckle–Wells Syndrome in a Child With Recurrent Urticaria
Elena M. Kamaltynova,
Iulia P. Chasovskikh,
Zinaida A. Maevskaia,
Svetlana O. Salugina,
Evgenii S. Fedorov,
Inna E. Gerbek https://doi.org/10.15690/vsp.v16i2.1721
Abstract
Cryopyrin associated periodic syndromes (CAPS) are rare monogenic autoinflammatory diseases from the group of hereditary periodic syndromes caused by a regulation defect of inflammatory cytokines, in particular interleukin 1β. They include familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS), and neonatal-onset multisystem inflammatory disease (CINCA/NOMID). Previously, Muckle–Wells syndrome was considered as a triad of symptoms — urticaria, deafness, and reactive amyloidosis. Today, the spectrum of symptoms is constantly expanding: it includes fever, fatigue, conjunctivitis, arthralgia, arthritis, myalgia, irritability, headache, abdominal pain, mouth ulcers, pericarditis, which involves doctors of different specialties in the diagnostic and treatment process, who are not always familiar with this disease. In Russia, single observations of this disease have been described. We present the clinical case of Muckle–Wells syndrome in a 5-year-old child, whose first symptoms appeared at the age of 2 months. This observation underscores the complexity of diagnosing the syndrome in children.
About the Authors
Elena M. Kamaltynova
Siberian State Medical University;
Regional Children’s Hospital
Russian Federation
Tomsk
Russian Federation
Tomsk
Iulia P. Chasovskikh
Siberian State Medical University
Russian Federation
Tomsk
Russian Federation
Tomsk
Zinaida A. Maevskaia
Siberian State Medical University;
Regional Children’s Hospital
Russian Federation
Tomsk
Russian Federation
Tomsk
Svetlana O. Salugina
Research Institute of Rheumatology named after V.A. Nasonova
Russian Federation
Moscow
Russian Federation
Moscow
Evgenii S. Fedorov
Research Institute of Rheumatology named after V.A. Nasonova
Russian Federation
Moscow
Russian Federation
Moscow
Inna E. Gerbek
Siberian State Medical University;
Tomsk Regional Clinical Hospital
Russian Federation
Tomsk
Russian Federation
Tomsk
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Review
For citations:
Kamaltynova E.M., Chasovskikh I.P., Maevskaia Z.A., Salugina S.O., Fedorov E.S., Gerbek I.E. Muckle–Wells Syndrome in a Child With Recurrent Urticaria. Current Pediatrics. 2017;16(2):180-183. (In Russ.) https://doi.org/10.15690/vsp.v16i2.1721
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