Reconsidered Concept of «Prebiotics» and Their Impact on the Child’s Organism
https://doi.org/10.15690/vsp.v16i6.1825
Abstract
Detection of a large number of oligosaccharides in breast milk predetermined their use in the composition of infant formula. The most studied prebiotic simulating the unique properties of breast milk oligosaccharides is the scGOS/lcFOS mixture. Its efficacy is confirmed in clinical studies. In 2017, the experts of the International Scientific Association of Probiotics and Prebiotics (ISAPP) adopted a new definition for «prebiotics», which greatly expanded the concept of their application. The World Allergy Organization (WAO) recommends the use of prebiotics in allergy- prone children. The guidelines are based on the results of studies of the influence of prebiotics on the intestinal microbi, a violation of the composition and functions of which predisposes to the development of allergy. Currently, the search for more promising technologies for the production of prebiotics continues.
About the Authors
Olga L. Lukoyanova
National Medical Research Center for Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
Disclosure of interest:
conducting research works with the support of Nestle, Heinz, Hero Rus, Philips
Tatyana E. Borovik
National Medical Research Center for Children’s Health
Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Disclosure of interest:
Russian Federation
Disclosure of interest:
conducting research works with the support of Nestle, Heinz, Hero Rus, Philips
Aleksandra V. Surzhik
National Medical Research Center for Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
Disclosure of interest:
conducting research works with the support of Nutricia
References
1. Prescott SL, Logan AC, Millstein RA, Katszman MA. Biodiversity, the human microbiome and mental health: moving toward a new clinical ecology for the 21st Century? International Journal of Biodiversity. 2016;2016:2718275. doi: 10.1155/2016/2718275.
2. David LA, Maurice CF, Carmody RN, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature. 2014; 505(7484):559–563. doi: 10.1038/nature12820.
3. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125(6):1401–1412.
4. Dosage-related bifidogenic effects of galacto- and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr. 2002;34(3):291–295. doi: 10.1097/00005176-200203000-00014.
5. Knol J, Scholtens P, Kafka C, et al. Colon microflora in infants fed formula with galacto- and fructo-oligosaccharides: more like breastfed infants. J Pediatr Gastroenterol Nutr. 2005;40(1):36–42.
6. Scholtens PA, Alliet P, Raes M, et al. Fecal secretory immunoglobulin A is increased in healthy infants who receive a formula with short-chain galacto-oligosaccharides and long- chain fructooligosaccharides. J Nutr. 2008;138(6):1141–1147.
7. van Hoffen E1, Ruiter B, Faber J, et al. A specific mixture of shortchain galacto- oligosaccharides and long-chain fructo-oligosaccharides induces a beneficial immunoglobulin profile in infants at high risk for allergy. Allergy. 2009;64(3):484–487. doi: 10.1111/j.1398-9995.2008.01765.x.
8. Bode L. Human milk oligosaccharides: every baby needs a sugar mama. Glycobiology. 2012;22(9):1147–1162. doi: 10.1093/glycob/cws074.
9. Bode L, Jantscher-Krenn E. Structure-function relationship of human milk oligosaccharides. Adv Nutr. 2012;3(3):383S–391S. doi: 10.3945/an.111.001404.
10. Bao Y, Chen C, Newburg DS. Quantification of neutral human milk oligosaccharides by graphitic carbon high-performance liquid chromatography with tandem mass spectrometry. Anal Biochem. 2013;433(1):28–35. doi: 10.1016/j.ab.2012.10.003.
11. Thurl S, Henker J, Siegel M, et al. Detection of four human milk groups with respect to Lewis blood group dependent oligosaccharides. Glycoconj J. 1997;14(7):795–799.
12. Rudloff S, Obermeier S, Borsch C, et al. Incorporation of orally applied C-galactose into milk lactose and oligosaccharides. Glycobiology. 2006;16(6):477–487. doi: 10.1093/glycob/cwj092.
13. Rudloff S, Pohlentz G, Borsch C, et al. Urinary excretion of in vivo 13C-labelled milk oligosaccharides in breastfed infants. Br J Nutr. 2011;107(7):957–963. doi: 10.1017/S0007114511004016.
14. Vos AP, M’Rabet L, Stahl B, et al. Immune-modulatory effects and potential working mechanisms of orally applied nondigestible carbohydrates. J Crit Rev Immunol. 2007;27(2):97–140.
15. Coppa GV, Zampini L, Galeazzi T. Prebiotics in human milk: a review. Dig Liver Dis. 2006;38 Suppl 2:S291–294. doi: 10.1016/S1590-8658(07)60013-9.
16. Jantscher-Krenn E, Zherebtsov M, Nissan C, et al. The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Gut. 2013;61(10):1417–1425. doi: 10.1136/gutjnl-2011-301404.
17. Zivkovic AM, German JB, Lebrilla CB, Mills DA. Human milk glycobiome and its impact on the infant gastrointestinal microbiota. Proc Natl Acad Sci U S A. 2011;108 Suppl 1:4653– 4658. doi: 10.1073/pnas.1000083107.
18. Wang B, Brand-Miller J, McVeagh P, Petocz P. Concentration and distribution of sialic acid in human milk and infant formulas. Am J Clin Nutr. 2001;74(4):510–515.
19. Gibson G, Hutkins R, Sanders M, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol. 2017;14:491–502. doi: 10.1038/nrgastro.2017.75.
20. Cuello-Garcia CA, Fiocchi A, Pawankar R, et al. World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): prebiotics. World Allergy Organ J. 2016;9:10. doi: 10.1186/s40413-016-0102-7.
21. Huang YJ, Marsland BJ, Bunyavanich S, et al. The microbiome in allergic disease: current understanding and future opportunities- 2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology. J Allergy Clin Immunol. 2017;139(4): 1099–1110. doi: 10.1016/j.jaci.2017.02.007.
22. Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med. 2014;20(2):159–166. doi: 10.1038/nm.3444.
23. Fransen CT, Van Laere KM, van Wijk AA, et al. alpha-D-Glcp-(1<->1)-beta-D-Galp- containing oligosaccharides, novel products from lactose by the action of beta- galactosidase. Carbohydr Res. 1998;314(1–2):101–114. doi: 10.1016/S0008-6215(98)00285-7.
24. Valdes-Varela L, Ruas-Madiedo P, Gueimonde M. In vitro fermentation of different fructo-oligosaccharides by Bifidobacterium strains for the selection of synbiotic combinations. Int J Food Microbiol. 2017;242:19–23. doi: 10.1016/j.ijfoodmicro.2016.11.011.
25. Vandenplas Y, Ludwig T, Bouritius H, et al. Randomised controlled trial demonstrates that fermented infant formula with shortchain galacto-oligosaccharides and long-chain fructo-oligosaccharides reduces the incidence of infantile colic. Acta Paediatr. 2017;106(7):1150–1158. doi: 10.1111/apa.13844.
26. ec.europa.eu [Internet]. Additional statement on the use of resistant short chain carbohydrates (oligofructosyl-saccharose and oligogalactosyl-lactose) in infant formulae and in follow-on formulae [cited 2017 Oct 19]. Available from: https://ec.europa.eu/food/sites/food/files/safety/docs/sci-com_scf_out109_en.pdf.
27. fsvps.ru [интернет]. Директива комиссии (EC) № 2006/141/ ЕС от 22.12.06 о смесях для детского питания первой и второй ступеней, вносящая изменения в Директиву 1999/21/ЕС [доступ от 21.10.2017]. Доступ по ссылке https://www.fsvps.ru/fsvpsdocs/ru/laws/eu/2006-141.pdf.
28. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the essential composition of infant and follow-on formulae. EFSA Journal. 2014;12(7):3760. doi: 10.2903/j.efsa.2014.3760.
29. Bruzzese E, Volpicelli M, Squeglia V, et al. A formula containing galacto- and fructooligosaccahrides prevents intestinal and extra intestinal infections: аn observational study. Clin Nutr. 2009;28(2):156–161. doi: 10.1016/j.clnu.2009.01.008.
30. Gruber C, van Stuivenberg M, Mosca F, et al. Immunoactive prebiotics transiently prevent occurrence of early atopic dermatitis among low-atopy-risk infants. J Allergy Clin Immunol. 2015;136(6):1696–1698.e1. doi: 10.1016/j.jaci.2015.07.049.
31. Boyle RJ, Tang ML, Chiang WC, et al. Prebiotic-supplemented partially hydrolysed cow’s milk formula for the prevention of eczema in high-risk infants: a randomized controlled trial. Allergy. 2016;71(5):701–710. doi: 10.1111/all.12848.
32. Sprenger GA, Baumgartner F, Albermann C. Production of human milk oligosaccharides by enzymatic and whole-cell microbial biotransformations. J Biotechnol. 2017;258:79–91. doi: 10.1016/j.jbiotec.2017.07.030.
33. Huang D, Yang K, Liu J, et al. Metabolic engineering of Escherichia coli for the production of 2’-fucosyllactose and 3-fucosyllactose through modular pathway enhancement. Metab Eng. 2017;41: 23–38. doi: 10.1016/j.ymben.2017.03.001.
34. Moro G, Minoli I, Mosca M, et al. Dosage-related bifidogenic effects of galacto-and fructooligosaccharides in formula-fed term infants. J Pediatr Gastroenterol Nutr. 2002;34(3):291–295.
35. Coulet M, Phothirath P, Constable A, et al. Pre-clinical safety assessment of the synthetic human milk, nature-identical, oligosaccharide lacto-N-neotetraose (LNnT). Food Chem Toxicol. 2013; 62:528–537. doi: 10.1016/j.fct.2013.09.018.
36. Coulet M, Phothirath P, Allais L. Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2’-O-Fucosyllactose (2’FL). Regul Toxicol Pharmacol. 2014; 68(1):59–69. doi: 10.1016/j.yrtph.2013.11.005.
37. Marriage BJ, Buck RH, Goehring KC, et al. Infants fed a lower calorie formula with 2’FL show growth and 2’FL uptake like breastfed infants. J Pediatr Gastroenterol Nutr. 2015;61(6):649–658. doi: 10.1097/MPG.0000000000000889.
38. Puccio G, Alliet P, Cajozzo C, et al. Effects of infant formula with human milk oligosaccharides on growth and morbidity: a randomized multicenter trial. J Pediatr Gastroenterol Nutr. 2017;64(4): 624–631. doi: 10.1097/MPG.0000000000001520.
39. Aly H, Said RN, Wali IE, et al. Medically-graded honey supplementation formula to preterm infants as a prebiotic: а randomized controlled trial. J Pediatr Gastroenterol Nutr. 2017;64(6):966–970. doi: 10.1097/MPG.0000000000001597.
Review
For citations:
Lukoyanova O.L., Borovik T.E., Surzhik A.V. Reconsidered Concept of «Prebiotics» and Their Impact on the Child’s Organism. Current Pediatrics. 2017;16(6):516-521. (In Russ.) https://doi.org/10.15690/vsp.v16i6.1825
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