THE ROLE OF EPIDERMAL BARRIER IMPAIRMENTS IN ATOPIC DERMATITIS: MODERN CONCEPTS OF DISEASE PATHOGENESIS
https://doi.org/10.15690/vsp.v17i1.1859
Abstract
Atopic dermatitis is a common chronic inflammatory skin disease characterized by a recurring course and progressive decrease in the quality of life. Recent studies in this area demonstrate the multifaceted pathogenesis of atopic dermatitis. Interaction of such factors as epidermal dysfunction, immune system disorders, and the consequences of genetic mutations contributes not only to the development of the disease but also to its progression and chronic course. The article presents various components of the etiopathogenesis of atopic dermatitis, describes the role of lipids, thereby the new therapeutic targets are revealed to specialists.
Supporting agencies: Zeldis-Pharma LLC
About the Authors
Nikolay N. Murashkin
National Medical Research Center of Children’s Health; Sechenov First Moscow State Medical University (Sechenov University)
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Receiving research grants from pharmaceutical companies Jansen, Eli Lilly; receiving fees for scientific consulting from Galderma, Bayer, Meda, Jansen, Pfizer, Zeldis-Pharma LLC
Eduard T. Ambarchian
National Medical Research Center of Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Not declared
Alexander I. Materikin
National Medical Research Center of Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Not declared
Roman V. Epishev
National Medical Research Center of Children’s Health
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Not declared
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Review
For citations:
Murashkin N.N., Ambarchian E.T., Materikin A.I., Epishev R.V. THE ROLE OF EPIDERMAL BARRIER IMPAIRMENTS IN ATOPIC DERMATITIS: MODERN CONCEPTS OF DISEASE PATHOGENESIS. Current Pediatrics. 2018;17(1):85-88. (In Russ.) https://doi.org/10.15690/vsp.v17i1.1859
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