COMPARATIVE ANALYSIS OF ENDOTHELIAL FUNCTION AND ELASTICCHARACTERISTICS OF THE ARTERIES IN CHILDREN WITH JUVENILE IDIOPATHIC AND REACTIVE ARTHRITIS
https://doi.org/10.15690/vsp.v13i2.983
Abstract
Aim: to estimate function of the endothelium and arterial elastic characteristics in children with various manifestations of juvenile
idiopathic (JIA) and reactive arthritis (ReA) and possible use of studied indicators for early and differential diagnostics. Patients and methods: in cross sectional study we analyzed arterial stiffness (SIngl) and endothelial function of 36 patients with JIA, 32 — with ReA and 23 healthy children with help of the pulse contour analysis. Results: children with JIA had significantly higher SIngl values (p = 0,0095) than patients with ReA and healthy children. SIngl of children with JIA positively correlated with disease activity (rs = 0,33; p = 0,048) and did not depend on duration of disease (rs = 0,025; p = 0,89). Children with JIA had significantly lower endothelialdependent vasodilatation function in comparison with healthy children (p = 0,026), but not with patients with ReA (p = 0,598). Conclusions: arterial stiffness in children with JIA significantly differs from indicators of patients with ReA and healthy children already at early stages of the disease and can be used as additional diagnostic criterion.
idiopathic (JIA) and reactive arthritis (ReA) and possible use of studied indicators for early and differential diagnostics. Patients and methods: in cross sectional study we analyzed arterial stiffness (SIngl) and endothelial function of 36 patients with JIA, 32 — with ReA and 23 healthy children with help of the pulse contour analysis. Results: children with JIA had significantly higher SIngl values (p = 0,0095) than patients with ReA and healthy children. SIngl of children with JIA positively correlated with disease activity (rs = 0,33; p = 0,048) and did not depend on duration of disease (rs = 0,025; p = 0,89). Children with JIA had significantly lower endothelialdependent vasodilatation function in comparison with healthy children (p = 0,026), but not with patients with ReA (p = 0,598). Conclusions: arterial stiffness in children with JIA significantly differs from indicators of patients with ReA and healthy children already at early stages of the disease and can be used as additional diagnostic criterion.
About the Authors
V. L. Мarchuk
Omsk State Medical Academy
Russian Federation
Varvara Marchuk, graduate student
Russian Federation
Varvara Marchuk, graduate student
N. V. Sobotuyk
Omsk State Medical Academy
Russian Federation
Russian Federation
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Review
For citations:
Мarchuk V.L., Sobotuyk N.V. COMPARATIVE ANALYSIS OF ENDOTHELIAL FUNCTION AND ELASTICCHARACTERISTICS OF THE ARTERIES IN CHILDREN WITH JUVENILE IDIOPATHIC AND REACTIVE ARTHRITIS. Current Pediatrics. 2014;13(2):124-128. (In Russ.) https://doi.org/10.15690/vsp.v13i2.983
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