Clinical Case of Rare Variant of Inherited Dermatosis: Acrodermatitis Enteropathica

Background. Acrodermatitis enteropathica is the rare form of inherited dermatoses. The disease onset in children is associated with the ablactation and the beginning of cow milk products use, that makes differential diagnosis of acrodermatitis and allergic dermatoses pretty difficult. The caution of specialists to hypozincemia at periorificial dermatitis combined with alopecia and diarrhea in infants will allow to establish correct diagnosis and choose management timely. Clinical Case Description. The clinical case of erosive- desquamative dermatitis combined with alopecia and hypozincemia is presented in this article. Positive dynamics of skin lesion due to administration with zinc sulfate medication is shown. Conclusion. The presence of periorificial dermatitis in the child of any age requires to perform the differential diagnosis for zinc deficiency conditions.

1. Mortz CG, Brockow K, Bindslev-Jensen C, Broesby-Olsen S. It looks like childhood eczema but is it? Clin Exp Allergy. 2019;49(6):744-753. doi: 10.1111/cea.13381.

2. Danbolt N. Acrodermatitis enteropathica. Br J Dermatol. 1979; 100(1):37-40. doi: 10.1111/j.1365-2133.1979.tb03567.x.

3. Kulichenko TV, Lashkova YS, Pushkov AA, Savostianov KV. Case of enteropathic acrodermatitis due to genetic mutations not previously described in literature. Current Pediatrics. 2016;15(4):391-395. (In Russ). doi: 10.15690/vsp.v15i4.159.

4. Del Ciampoa I, Sawamurab R, del Ciampob L, Fernandes M. Acrodermatite enteropatica: manifestacoes clinicas e diagnostic pediatrico. Rev Paul Pediatr. 2018;36(2). doi: 10.1590/1984-0462/;2018;36;2;00010.

5. Glutsch V, Hamm H, Goebeler M. Zinc and skin: an update. J Dtsch Dermatol Ges. 2019;17(6):589-596. doi: 10.1111/ddg.13811.

6. Ota E, Mori R, Middleton P et al. Zinc supplementation for improving pregnancy and infant outcome. Cochrane Database Syst Rev. 2015;(2):CD000230. doi: 10.1002/14651858.CD000230. pub5.

7. Kaya Erdogan H, Bulur I, Saracoglu ZN, et al. Acrodermatitis enteropathica: a novel mutation of the SLC39A4 gene in a Turkish boy. J Dermatol. 2016;43(8):966-968. doi: 10.1111/1346-8138.13313.

8. Roman MA, Arroyo AE. Acrodermatiti enteropatica. Bol Med Hosp Infant Mex.