Genetic Factors Associated with Toe Walking in Children
https://doi.org/10.15690/vsp.v19i2.2108
Abstract
The article describes genetic factors associated with toe walking in children. Association of gait abnormality with variants in genes listed below is shown: PMP22 (peripheral myelin protein 22), EGR2 (early growth response protein 2), AIFM1 (apoptosis inducing factor mitochondria associated 1), MORC2 (member of the Microrchidia family CW-type zinc finger 2), DHTKD1 (dehydrogenase E1 and transketolase domain containing 1), GDAP1 (ganglioside induced differentiation associated protein 1), KIF1B (kinesin family member 1B), FGD4 (FYVE, RhoGEF and PH domain containing 4), SBF2 (SET binding factor 2), SH3TC2 (SH3 domain and tetratricopeptide repeats 2), NAGLU (N-acetyl-alpha-glucosaminidase), NEFL (neurofilament light) и PRX (periaxin). Genetic testing of patients with toe walking is crucial for accurate diagnostics of this pathology as well as clinical examination.
Supporting agencies: Not specified.
About the Authors
David Pomarino
Praxis Pomarino
Germany
Hamburg.
Disclosure of interest:
Germany
Hamburg.
Disclosure of interest:
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren are the employees of commercial organization Praxis Pomarino (Hamburg, Germany). This organization is engaged in diagnostics and management of children with idiopathic toe walking. David Pomarino is the head of Praxis Pomarino, Anneke Thren is the doctor at Praxis Pomarino, Stefaine Morigeau and Johanna R. Thren are assistants at Praxis Pomarino. Anna A. Emelina confirmed the absence of a reportable conflict of interests.
Anneke Thren
Praxis Pomarino
Germany
Hamburg.
Disclosure of interest:
Germany
Hamburg.
Disclosure of interest:
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren are the employees of commercial organization Praxis Pomarino (Hamburg, Germany). This organization is engaged in diagnostics and management of children with idiopathic toe walking. David Pomarino is the head of Praxis Pomarino, Anneke Thren is the doctor at Praxis Pomarino, Stefaine Morigeau and Johanna R. Thren are assistants at Praxis Pomarino. Anna A. Emelina confirmed the absence of a reportable conflict of interests.
Stefaine Morigeau
Praxis Pomarino
Germany
Hamburg.
Disclosure of interest:
Germany
Hamburg.
Disclosure of interest:
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren are the employees of commercial organization Praxis Pomarino (Hamburg, Germany). This organization is engaged in diagnostics and management of children with idiopathic toe walking. David Pomarino is the head of Praxis Pomarino, Anneke Thren is the doctor at Praxis Pomarino, Stefaine Morigeau and Johanna R. Thren are assistants at Praxis Pomarino. Anna A. Emelina confirmed the absence of a reportable conflict of interests.
Johanna R. Thren
Praxis Pomarino
Germany
Hamburg.
Disclosure of interest:
Germany
Hamburg.
Disclosure of interest:
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren are the employees of commercial organization Praxis Pomarino (Hamburg, Germany). This organization is engaged in diagnostics and management of children with idiopathic toe walking. David Pomarino is the head of Praxis Pomarino, Anneke Thren is the doctor at Praxis Pomarino, Stefaine Morigeau and Johanna R. Thren are assistants at Praxis Pomarino. Anna A. Emelina confirmed the absence of a reportable conflict of interests.
Anna A. Emelina
Samara State Medical University
Russian Federation
Samara.
Disclosure of interest:
Russian Federation
Samara.
Disclosure of interest:
David Pomarino, Anneke Thren, Stefaine Morigeau, Johanna R. Thren are the employees of commercial organization Praxis Pomarino (Hamburg, Germany). This organization is engaged in diagnostics and management of children with idiopathic toe walking. David Pomarino is the head of Praxis Pomarino, Anneke Thren is the doctor at Praxis Pomarino, Stefaine Morigeau and Johanna R. Thren are assistants at Praxis Pomarino. Anna A. Emelina confirmed the absence of a reportable conflict of interests.
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For citations:
Pomarino D., Thren A., Morigeau S., Thren J.R., Emelina A.A. Genetic Factors Associated with Toe Walking in Children. Current Pediatrics. 2020;19(2):146-149. (In Russ.) https://doi.org/10.15690/vsp.v19i2.2108
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