TREATMENT OF ALLERGIC RHINITIS IN CHILDREN: SELECTION OF ANTIHISTAMINE DRUG AND NECESSITY OF FURTHER INVESTIGATIONS
https://doi.org/10.15690/vsp.v12i6.876
Abstract
This literature review contains analysis of research results on treatment of allergic rhinitis in children according to the evidence-based medicine. Oral and intranasal antihistamine drugs along with intranasal steroids are the first-line drugs for treatment of allergic rhinitis, although the latter are more efficient in suppression of nasal stuffiness. First- and second-generation antihistamine agents used nowadays in medical practice are discussed in the article. The advantages of non-sedative 2d-genereation antihistamine drugs, especially so called active metabolites (fexofenadine, cetirizine, levocetirizine, desloratadine) are emphasized. The data on loratadine and desloratadine as ones of the most effective drugs in childhood allergic rhinitis are shown in detail. The possible directions for the further investigations in order to provide effective control over allergic inflammation in children resistant to medicinal agents are discussed.
About the Author
A. V. Karaulov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Karaulov Aleksandr Viktorovich, Doctor of Medical Science, Professor, Corresponding Member of the Russian Academy of Medical Sciences, Head of the Department of Clinical Immunology and Allergy
Russian Federation
Karaulov Aleksandr Viktorovich, Doctor of Medical Science, Professor, Corresponding Member of the Russian Academy of Medical Sciences, Head of the Department of Clinical Immunology and Allergy
References
1. Guschin I. S., Ilyina N. I., Polner S. A. Allergichesky rinit. Posobiye dlya vrachey [Allergic rhinitis. Manual for physicians]. Moscow, Institut Immunologii Publ., 2002. 68 p.
2. Roberts G., Xatzipsalty M., Borrego L. M. et al. Paediatric rhinitis: position paper of the European Academy of Allergy and Clinical Immunology. Allergy. 2013; 68: 1102–1116.
3. Ant K., Pearce N., Anderson H. R. et al. Global map of the prevalence of symptoms of rhinoconjunctivts in children. The international study of Asthma and Allergies in Childhood ISAAC Phase Three. Allergy. 2009; 64: 123–148.
4. Karaulov A. V., Sidorenko I. V., Bosenko Yu. A. Rasprostranennost i klinicheskiye osobennosti allergicheskogo rinita u detey 1,5–4 let [Prevalence and clinical features of allergic rhinitis in children of 1.5–4 year-olds]. Rossyskiy allergologicheskiy zhurnal — Russian Allergology Journal. 2007; 4: 42–47.
5. Allergologiya i immunologiya [Allergology and immunology]. Under the general editorship of A. A. Baranov and R. M. Khaitov. Moscow, Soyuz pediatrov Rossii Publ., 2010. P. 75–91.
6. Karaulov A. V., Sidorenko I. V., Zakharzhevskaya T. V., Treskunov V. K. Antigistaminnye preparaty v lechenii allergicheskikh zabolevaniy u detey [Antihistamines in treating allergic diseases in children]. Rossyskiy allergologicheskiy zhurnal — Russian Allergology Journal. 2005; 2: 81–83.
7. Karaulov A. V. Novye kontseptsii razvitiya bronkhialnoy astmy: immunologicheskiye i geneticheskiye aspekty [New concepts of bronchial asthma development: Immunological and genetic aspects]. Praktikuyushchiy vrach — Practicing physician. 1998; 2: 3–5.
8. Karaulov A. V. Klinicheskaya immunologiya i allergologiya [Clinical Immunology and Allergology]. Moscow, MIA Publ., 2002. 651 p.
9. Gevorkyan A. K., Tomilova A.Yu., Namazova L. S., Botvinyeva V. V. Allergicheskiy rinit: diagnostika i lecheniye [Allergic rhinitis: Diagnosis and treatment]. Pediatricheskaya Farmakologiya — Pediatric Pharmacology. 2008; 5 (1): 62–67.
10. Bousquet J., Van Cauwenberge P., Khaltaev N. Allergic rhinitis and its impact on asthma. J. Allergy Clin. Immunol. 2001; 108 (Suppl. 5): 147–334.
11. Bachert C. A Review of the efficacy of Desloratadine, Fexofenadine and Levocetirizine in the treatment of Nasal congestion in patients with Allergic Rhinitis. Сlin. Ther. 2009; 3 (5): 921–944.
12. Karaulov A. V., Sidorenko I. V. Sovremennye protivoallergicheskie sredstva v apteke [Current Antiallergic Drugs in Pharmacy]. Moscow, MTsFER, 2006. 234 p.
13. Bousquet J., Bindsev, Jensen C. et al. The ARIA/EAACI criteria for antihistamines. Assessment of the efficacy, safety and pharmacology of desloratadine. Allergy. 2004; 59 (Suppl. 77): 4–16.
14. Vishnyova E. A., Alekseeva A. A., Gevorkyan A. K. Primeneniye dezloratadina pri allergicheskom rinite i soputstvuyushchey bronkhial noy astme u detey [Application of desloratadine in allergic rhinitis and concomitant bronchial asthma in children]. Pediatricheskaya Farmakologiya — Pediatric Pharmacology. 2008; 5 (2): 33–37.
15. Karaulov A. V. Klarotadin v lechenii allergicheskikh zabolevaniy [Clarotadine in the treatment of allergic diseases]. Rossyskiy immunologicheskiy zhurnal — Russian Immunology Journal. 2001; 6 (1): 109–112.
16. Clissold S. P., Sorkin E. M., Goa K. L. Loratadine: a preliminary review of its pharmacodynamic properties and therapeutic efficacy. Drugs. 1989; 37 (1): 42–57.
17. Roman I. J., Danzing M. R. Loratadine. A review of recent findings in pharmacology, pharmacokinetics, efficacy and safety, with a look at its use in combination with pseudoephedrine. Clin. Rev. Allergy. 1993; 11: 89–109.
18. Wilkinson C., Moskowitz H. Presented at llth International Conference on Alcohol, Drugs and Traffic Safety. Chicago. 1989.
19. van Cauwenberge P. B. Drug Invest. 1992; 4 (4): 283–291.
20. Yang Y. H., Lin Y. T., Lu M. Y., Tsai M. J., Chiang B. L. A doubleblind, placebocontrolled, and randomized study of loratadine (Clarityne) syrup for the treatment of allergic rhinitis in children aged 3 to 12 years. Asian Pac. J. Allergy Immunol. 2001; 19: 171–175.
21. Keam S. J., Plosker G. L. Rupatadine: a review of its use in the management of allergic disorders. Drugs. 2007; 67: 457–474.
22. Berger W. E. The safety and efficacy of desloratadine for the mana gement of allergic disease. Drug Saf. 2005; 28 (12): 1101–1118.
23. Schenkel E. J. Effect of desloratadine on the control of morning symptoms in patients with seasonal and perennial allergic rhinitis. Allergy Asthma Proceed. 2006; 27 (8): 465–472.
24. Villa E., Rogkakou A., Garelli V., Canonica G. W. Review of deslora tadine data using the ARIA guidelines. WAO J. 2012; 5: 6–13.
25. Baena Cagnani C. Desloratadine activity in concurrent seasonal allergic rhinitis and asthma. Allergy. 2001; 56 (Suppl. 65): 21–27.
26. Norman P., Dimmann A., Rabasseda. Desloratadine: a preclinical and clinical overview. Drugs Today. 2001; 37 (4): 215–227.
27. Karaulov A. V. Antigistaminnye preparaty s pozitsiy dokazatelnoy meditsiny: vybor preparatov pri allergicheskom rinite [Antihistamines from the evidence-based medicine point of view: Choosing drugs for allergic rhinitis treatment]. Rossyskiy allergologicheskiy zhurnal — Russian Allergology Journal. 2013; 2: 43–49.
28. Zakharzhevskaya T. V., Sidorenko I. V., Treskunov V. K., Karaulov A. V. Vozmozhnosti ispolzovaniya novogo nazalnogo spreya nazal v lechenii i profilaktike allergicheskogo rinita [Possibility of using the new nasal spray Nasal in treatment and prevention of allergic rhinitis]. Rossyskiy allergologicheskiy zhurnal — Russian Allergology Journal. 2009; 4: 82–86.
29. Brozek J., Bousquet J., Baena-Cagani C., Bonini S., Canonica G., Casale T. et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines — 2010 Revision using GRADE. J. Allergy Clin. Immunol. 2010; 126: 466–476.
Review
For citations:
Karaulov A.V. TREATMENT OF ALLERGIC RHINITIS IN CHILDREN: SELECTION OF ANTIHISTAMINE DRUG AND NECESSITY OF FURTHER INVESTIGATIONS. Current Pediatrics. 2013;12(6):67-72. (In Russ.) https://doi.org/10.15690/vsp.v12i6.876
Views:
995
Email this article 
