DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN
https://doi.org/10.15690/vsp.v12i5.807
Abstract
Aim: to investigate sFas-receptor and its ligand, sFas-L, cytochrome C and annexin V as the apoptotic markers in children with CKD to determine the renal cell apoptosis role in the progression of a renal disease. Patients and methods: 68 children with CKD 1–3 from 3 to 17 years were examined. Results: sFas-R, sFas-L, annexin V significant differed from normal value at all stages of CKD. Cytochrome C level was significantly higher than normal in children with CKD1. But tended to increase at and 2 and 3 stages correspondingly. Significant correlation was determinated between proteinuria and the combination of all four markers. Сomparing serum levels of apoptosis markers in children with non-immune disorders without renal dysfunction treated and iACE not treated and in patients with CKD-2 t a significant excess of the level of sFas-R in patients without iACE therapy was found. Conclusions: Fas-mediated and mitochondrial programmed cell death are implicated in development and progression of CKD. ACE inhibitors reduced the severity of apoptosis, primarily by inhibiting the activity of its Fas-mediated pathway.
About the Authors
O. V. Komarova
Scientific Centre of Children Health of RAMS, Moscow
Russian Federation
Komarova Olga Viktorovna, Candidate of Medical Sciences, Senior Researcher of the Department of Nephrology
Russian Federation
Komarova Olga Viktorovna, Candidate of Medical Sciences, Senior Researcher of the Department of Nephrology
A. G. Kucherenko
Scientific Centre of Children Health of RAMS, Moscow
Russian Federation
Russian Federation
I. E. Smirnov
Scientific Centre of Children Health of RAMS, Moscow
Russian Federation
Russian Federation
A. N. Tsygin
Scientific Centre of Children Health of RAMS, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Komarova O.V., Kucherenko A.G., Smirnov I.E., Tsygin A.N. DYNAMICS OF CONCENTRATION OF APOPTOSIS SERUM MARKERS IN ASSESSMENT OF PROGNOSIS OF CHRONIC KIDNEY DISEASE IN CHILDREN. Current Pediatrics. 2013;12(5):104-107. (In Russ.) https://doi.org/10.15690/vsp.v12i5.807
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