Prevalence of Vitamin D Insufficiency/Deficiency and Their Role in Atopic Dermatitis Development and Course in Children
https://doi.org/10.15690/vsp.v21i4.2435
Abstract
Various conclusive evidence on the role of vitamin D in the pathogenesis of atopic dermatitis (AD) has been obtained in recent decades. Many studies have shown that patients with AD have low concentration of 25(OH)D in blood associated with high concentration of allergen specific IgE (according to several reports). The analysis of low 25(OH)D concentration prevalence, association of vitamin D deficiency with AD severity and sensitization to allergens, and association of vitamin D disorders with risk of AD development is presented.
About the Authors
Tatiana S. Kashinskaya
Altai State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Barnaul
Disclosure of interest:
Not declared
Natalia V. Shakhova
Altai State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Barnaul
Disclosure of interest:
Not declared
Yrij F. Lobanov
Altai State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Barnaul
Disclosure of interest:
Not declared
Elena M. Kamaltynova
Siberian State Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Tomsk
Disclosure of interest:
Not declared
References
1. Bickers DR, Lim HW, Margolis D, Weinstock MA, et al. American Academy of Dermatology Association; Society for Investigative Dermatology. The burden of skin diseases: 2004 a joint project of the American Academy of Dermatology Association and the Society for Investigative Dermatology. J Am Acad Dermatol. 2006;55(3): 490–500. doi: https://doi.org/10.1016/j.jaad.2006.05.048
2. Hallit S, Raherison C, Malaeb D, et al. The AAA Risk Factors Scale: A New Model to Screen for the Risk of Asthma, Allergic Rhinitis and Atopic Dermatitis in Children. Med Princ Pract. 2018;27(5): 472–480. doi: https://doi.org/10.1159/000490704
3. McDonnell DP, Mangelsdorf DJ, Pike JW, et al. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science. 1987;235(4793):1214–1217. doi: https://doi.org/10.1126/science.3029866
4. Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5(7):2502–2521. doi: https://doi.org/10.3390/nu5072502
5. Tsoukas CD, Provvedini DM, Manolagas SC. 1,25-dihydroxyvitamin D3: a novel immunoregulatory hormone. Science. 1984;224(4656):1438–1440. doi: https://doi.org/10.1126/science.6427926
6. Gour N, Wills-Karp M. IL-4 and IL-13 signaling in allergic airway disease. Cytokine. 2015;75(1):68–78. doi: https://doi.org/10.1016/j.cyto.2015.05.014
7. D’Ambrosio D, Cippitelli M, Cocciolo MG, et al. Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J Clin Invest. 1998;101(1):252–262. doi: https://doi.org/10.1172/JCI1050
8. Chirumbolo S. Role of vitamin D3 in atopic dermatitis and immunity: some comments. Allergy Asthma Proc. 2015;36(3): 234–235. doi: https://doi.org/10.2500/aap.2015.34.3843
9. Di Filippo P, Scaparrotta A, Rapino D, et al. Vitamin D supplementation modulates the immune system and improves atopic dermatitis in children. Int Arch Allergy Immunol. 2015;166(2): 91–96. doi: https://doi.org/10.1159/000371350
10. Boonstra A, Barrat FJ, Crain C, et al. 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol. 2001;167(9):4974–4980. doi: https://doi.org/10.4049/jimmunol.167.9.4974
11. Lowry MB, Guo C, Borregaard N, Gombart AF. Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells. J Steroid Biochem Mol Biol. 2014;143:183–191. doi: https://doi.org/10.1016/j.jsbmb.2014.02.004
12. Chung C, Silwal P, Kim I, et al. Vitamin D-Cathelicidin Axis: at the Crossroads between Protective Immunity and Pathological Inflammation during Infection. Immune Netw. 2020;20(2):e12. doi: https://doi.org/10.4110/in.2020.20.e12
13. Bikle DD. Vitamin D and the skin. J Bone Miner Metab. 2010;28(2):117–130. doi: https://doi.org/10.1007/s00774-009-0153-8
14. Sharief S, Jariwala S, Kumar J, et al. Vitamin D levels and food and environmental allergies in the United States: results from the National Health and Nutrition Examination Survey 2005–2006. J Allergy Clin Immunol. 2011;127(5):1195–1202. doi: https://doi.org/10.1016/j.jaci.2011.01.017
15. Antal AS, Dombrowski Y, Koglin S, et al. Impact of vitamin D3 on cutaneous immunity and antimicrobial peptide expression. Dermatoendocrinol. 2011;3(1):18–22. doi: https://doi.org/10.4161/derm.3.1.14616
16. Han TY, Kong TS, Kim MH, et al. Vitamin D Status and Its Association with the SCORAD Score and Serum LL-37 Level in Korean Adults and Children with Atopic Dermatitis. Ann Dermatol. 2015;27(1):10–14. doi: https://doi.org/10.5021/ad.2015.27.1.10
17. Cheon BR, Shin JE, Kim YJ, et al. Relationship between serum 25-hydroxyvitamin D and interleukin-31 levels, and the severity of atopic dermatitis in children. Korean J Pediatr. 2015;58(3):96–101. doi: https://doi.org/10.3345/kjp.2015.58.3.96
18. Su O, Bahalı AG, Demir AD, et al. The relationship between severity of disease and vitamin D levels in children with atopic dermatitis. Postepy Dermatol Alergol. 2017;34(3): 224–227. doi: https://doi.org/10.5114/pdia.2017.66054
19. Sanmartin R, Pardos C, Doste D, et al. The association between atopic dermatitis and serum 25-hydroxyvitamin D in children: Influence of sun exposure, diet, and atopy features-A cross-sectional study. Pediatr Dermatol. 2020;37(2):294–300. doi: https://doi.org/10.1111/pde.14049
20. Farajzadeh S, Reghabatpour L, Aflatoonian M, et al. Assessment of serum level of 25-hydroxy-vitamin D in Iranian children with atopic dermatitis, in Kerman city, an area with high sun exposure. Journal of Pakistan Association of Dermatologists. 2015;25(2):96–100.
21. Guo Y, Yu L, Deng YH, et al. Associations between serum 25-hydroxyvitamin D levels and allergic sensitization in early childhood. Allergol Immunopathol (Madr). 2020;48(1):84–89. doi: https://doi.org/10.1016/j.aller.2019.06.016
22. Rudenko EV. Sovremennye tendentsii v diagnostike, profilaktike i lechenii defitsita vitamina D. Meditsinskie novosti. 2020;(8):31–36. (In Russ).
23. Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930. doi: https://doi.org/10.1210/jc.2011-0385
24. Cashman KD, Dowling KG, Skrabakova Z, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4): 1033–1044. doi: https://doi.org/10.3945/ajcn.115.120873
25. Maguire JL, Birken CS, O’Connor DL, et al. Prevalence and predictors of low vitamin D concentrations in urban Canadian toddlers. Paediatr Child Health. 2011;16(2):e11–e15. doi: https://doi.org/10.1093/pch/16.2.e11
26. Petrenya N, Lamberg-Allardt C, Melhus M, et al. Vitamin D status in a multi-ethnic population of northern Norway: the SAMINOR 2 Clinical Survey. Public Health Nutr. 2020;23(7):1186–1200. doi: https://doi.org/10.1017/S1368980018003816
27. Gessner BD, Plotnik J, Muth PT. 25-hydroxyvitamin D levels among healthy children in Alaska. J Pediatr. 2003;143(4):434–437. doi: https://doi.org/10.1067/S0022-3476(03)00410-4
28. Nichols EK, Khatib IM, Aburto NJ, et al. Vitamin D status and associated factors of deficiency among Jordanian children of preschool age. Eur J Clin Nutr. 2015;69(1):90–95. doi: https://doi.org/10.1038/ejcn.2014.142
29. Al-Alyani H, Al-Turki HA, Al-Essa ON, et al. Vitamin D deficiency in Saudi Arabians: A reality or simply hype: A meta-analysis (2008–2015). J Family Community Med. 2018;25(1):1–4. doi: https://doi.org/10.4103/jfcm.JFCM_73_17
30. Al-Daghri NM. Vitamin D in Saudi Arabia: Prevalence, distribution and disease associations. J Steroid Biochem Mol Biol. 2018;175:102–107. doi: https://doi.org/10.1016/j.jsbmb.2016.12.017
31. Torkaman M, Abolghasemi H, Amirsalari S, et al. Comparison of the Vitamin D Status of Children Younger and Older Than 2 Years in Tehran: Are Supplements Really Necessary? Int J Endocrinol Metab. 2016;14(2):e34676. doi: https://doi.org/10.5812/ijem.34676
32. Poh BK, Rojroongwasinkul N, Nguyen BK, et al. SEANUTS Study Group. 25-hydroxy-vitamin D demography and the risk of vitamin D insufficiency in the South East Asian Nutrition Surveys (SEANUTS). Asia Pac J Clin Nutr. 2016;25(3):538–548. doi: https://doi.org/10.6133/apjcn.092015.02
33. Cairncross CT, Stonehouse W, Conlon CA, et al. Predictors of vitamin D status in New Zealand preschool children. Matern Child Nutr. 2017;13(3):e12340. doi: https://doi.org/10.1111/mcn.12340
34. Horton-French K, Dunlop E, Lucas RM, et al. Prevalence and predictors of vitamin D deficiency in a nationally representative sample of Australian adolescents and young adults. Eur J Clin Nutr. 2021;75(11):1627–1636. doi: https://doi.org/10.1038/s41430-021-00880-y
35. Zaharova IN, Maltsev SV, Borovik TE, et al. Results of a multicenter research «Rodnichok» for the study of vitamin D insufficiency in infants in Russia. Pediatria. Journal n.a. G.N. Speransky. 2013;91(1):62–67. (In Russ).
36. Park JH, Hong IY, Chung JW, Choi HS. Vitamin D status in South Korean population: Seven-year trend from the KNHANES. Medicine (Baltimore). 2018;97(26):e11032. doi: https://doi.org/10.1097/MD.0000000000011032
37. Looker AC, Pfeiffer CM, Lacher DA, et al. Serum 25-hydroxyvitamin D status of the US population: 1988–1994 compared with 2000–2004. Am J Clin Nutr. 2008;88(6):1519–1527. doi: https://doi.org/10.3945/ajcn.2008.26182
38. Vijay K. Toll-like receptors in immunity and inflammatory diseases: Past, present, and future. Int Immunopharmacol. 2018;59: 391–412. doi: https://doi.org/10.1016/j.intimp.2018.03.002
39. Sroka-Tomaszewska J, Trzeciak M. Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int J Mol Sci. 2021;22(8):4130. doi: https://doi.org/10.3390/ijms22084130
40. Elisyutina OG. Klinicheskie fenotipy i molekulyarnogeneticheskaya kharakteristika endotipov atopicheskogo dermatita. [astract of dissertation]. Moscow; 2019. 48 p. (In Russ).
41. Novak N, Bieber T. FcεRI-Toll-like receptor interaction in atopic dermatitis. Curr Probl Dermatol. 2011;41:47–53. doi: https://doi.org/10.1159/000323295
42. Stukova ЕI, Keniksfest YV. Patuogenesis significance of staphylococcus aureus in atopic dermatitis. Fundamental Research. 2013;(7 Pt 3):680–687. (In Russ).
43. Yip KH, Kolesnikoff N, Yu C, et al. Mechanisms of vitamin D3 metabolite repression of IgE-dependent mast cell activation. J Allergy Clin Immunol. 2014;133(5):1356–1364, 1364.e1–e14. doi: https://doi.org/10.1016/j.jaci.2013.11.030
44. Lipinska-Opalka A, Tomaszewska A, Kubiak JZ, Kalicki B. Vitamin D and Immunological Patterns of Allergic Diseases in Children. Nutrients. 2021;13(1):177. doi: https://doi.org/10.3390/nu13010177
45. Anderson J, Do LAH, Toh ZQ, et al. Vitamin D Induces Differential Effects on Inflammatory Responses During Bacterial and/or Viral Stimulation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2020;11:602. doi: https://doi.org/10.3389/fimmu.2020.00602
46. Xie Z, Komuves L, Yu QC, et al. Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. J Invest Dermatol. 2002;118(1):11–16. doi: https://doi.org/10.1046/j.1523-1747.2002.01644.x
47. Bikle DD, Gee E, Pillai S. Regulation of keratinocyte growth, differentiation, and vitamin D metabolism by analogs of 1,25-dihydroxyvitamin D. J Invest Dermatol. 1993;101(5):713–718. doi: https://doi.org/10.1111/1523-1747.ep12371681
48. Smith M, O’Brien EC, Alberdi G, et al. Association between vitamin D status in early pregnancy and atopy in offspring in a vitamin D deplete cohort. Ir J Med Sci. 2020;189(2):563–570. doi: https://doi.org/10.1007/s11845-019-02078-5
49. Wei Z, Zhang J, Yu X. Maternal vitamin D status and childhood asthma, wheeze, and eczema: A systematic review and metaanalysis. Pediatr Allergy Immunol. 2016;27(6):612–619. doi: https://doi.org/10.1111/pai.12593
50. Luo C, Hong D-D, Sun Y-N, et al. Early life Vitamin D supplementation for preventing allergic diseases: A systematic review and meta-analysis of randomized controlled trials. Authorea. 2020. October 08. Available online: https://www.authorea.com/users/365342/articles/485479-early-life-vitamin-dsupplementation-for-preventing-allergic-diseases-a-systematicreview-and-meta-analysis-of-randomized-controlled-trials?commit=7dceab91720eebce7d63fd270fa884a430cb1dac. Accessed on August 25, 2022.
51. Li MM, Lu CY, Wang XM. Predictive value of cord blood 25(OH)D3 for early infantile atopic dermatitis. Zhongguo Dang Dai Er Ke Za Zhi. 2018;20(4):303–307. doi: https://doi.org/10.7499/j.issn.1008-8830.2018.04.010
52. Palmer DJ, Sullivan TR, Skeaff CM, et al. Higher cord blood 25-hydroxyvitamin D concentrations reduce the risk of early childhood eczema: in children with a family history of allergic disease. World Allergy Organ J. 2015;8(1):28. doi: https://doi.org/10.1186/s40413-015-0077-9
53. Pacheco-Gonzalez RM, Garcia-Marcos L, Morales E. Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies. Pediatr Allergy Immunol. 2018; 29(3):243–253. doi: https://doi.org/10.1111/pai.12876
54. Rueter K, Jones AP, Siafarikas A, et al. In “High-Risk” Infants with Sufficient Vitamin D Status at Birth, Infant Vitamin D Supplementation Had No Effect on Allergy Outcomes: A Randomized Controlled Trial. Nutrients. 2020;12(6):1747. doi: https://doi.org/10.3390/nu12061747
55. Back O, Blomquist HK, Hernell O, Stenberg B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol. 2009;89(1):28–32. doi: https://doi.org/10.2340/00015555-0541
56. Kashinskaya TS, Shakhova NV. Narusheniya priema vitamina D u detei pervogo goda zhizni, kak risk razvitiya atopicheskogo dermatita u doshkol’nikov. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(4): 232–233. (In Russ).
57. Cheng HM, Kim S, Park GH, et al. Low vitamin D levels are associated with atopic dermatitis, but not allergic rhinitis, asthma, or IgE sensitization, in the adult Korean population. J Allergy Clin Immunol. 2014;33(4):1048–1055. doi: https://doi.org/10.1016/j.jaci.2013.10.055
58. Hattangdi-Haridas SR, Lanham-New SA, Wong WHS, et al. Vitamin D Deficiency and Effects of Vitamin D Supplementation on Disease Severity in Patients with Atopic Dermatitis: A Systematic Review and Meta-Analysis in Adults and Children. Nutrients. 2019;11(8):1854. doi: https://doi.org/10.3390/nu11081854
59. Kashinskaya TS, Shakhova NV. Association Between 25(ОН)D Concentration and Atopic Dermatitis and Its Severity Children Aged from 3 to 6 Years: Cross Sectional Study. Voprosy sovremennoi pediatrii — Current Pediatrics. 2021;20(3):232–237. (In Russ). doi: https://doi.org/10.15690/vsp.v20i3/2273
60. Lee YW, Choon SE, Izham S. Serum 25-Hydroxyvitamin D deficiency in Malaysian children with severe atopic dermatitis. Med J Malaysia. 2019;74(4):259–265.
61. Hata TR, Audish D, Kotol P, et al. A randomized controlled doubleblind investigation of the effects of vitamin D dietary supplementation in subjects with atopic dermatitis. J Eur Acad Dermatol Venereol. 2014;28(6):781–789. doi: https://doi.org/10.1111/jdv.12176
62. Chaweekulrat P, Suppasilp C, Suktitipat B. A Systematic Review and Meta-analysis of Association between Serum Vitamin D and Atopic Dermatitis. Siriraj Med J. 2015;67:219–226.
63. Akan A, Azkur D, Ginis T, et al. Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations. Pediatr Dermatol. 2013;30(3):359–363. doi: https://doi.org/10.1111/pde.12058
64. Robl R, Uber M, Abagge KT, et al. Serum Vitamin D Levels Not Associated with Atopic Dermatitis Severity. Pediatr Dermatol. 2016;33(3):283–288. doi: https://doi.org/10.1111/pde.12795
65. Amestejani M, Salehi BS, Vasigh M, et al. Vitamin D supplementation in the treatment of atopic dermatitis: a clinical trial study. J Drugs Dermatol. 2012;11(3):327–330.
66. Imoto RR, Uber M, Abagge KT, et al. Vitamin D supplementation and severity of atopic dermatitis: pre-post assessment. Allergol Immunopathol (Madr). 2021;49(2):66–71. doi: https://doi.org/10.15586/aei.v49i2.67
67. Kim MJ, Kim SN, Lee YW, et al. Vitamin D Status and Efficacy of Vitamin D Supplementation in Atopic Dermatitis: A Systematic Review and Meta-Analysis. Nutrients. 2016;8(12):789. doi: https://doi.org/10.3390/nu8120789
68. Kim G, Bae JH. Vitamin D and atopic dermatitis: A systematic review and meta-analysis. Nutrition. 2016;32(9):913–920. doi: https://doi.org/10.1016/j.nut.2016.01.023
69. Zhu Z, Yang Z, Wang C, Liu H. Assessment of the Effectiveness of Vitamin Supplement in Treating Eczema: A Systematic Review and Meta-Analysis. Evid Based Complement Alternat Med. 2019; 2019:6956034. doi: https://doi.org/10.1155/2019/6956034
70. Ercan N, Bostanci IB, Ozmen S, Tekindal MA. Is there an association between vitamin D levels and cow’s milk protein allergy at infancy? Arch Argent Pediatr. 2019;117(5):306–313. doi: https://doi.org/10.5546/aap.2019.eng.306
71. Baek JU, Hwangbo JW, Lee HR, Lee SY. Vitamin D insufficiency is associated with food sensitization in children under 2 years with atopic dermatitis. Allergy Asthma Respir Dis. 2013;1(3):211–215.
72. Kashinskaya TS, Shakhova NV. Assotsiatsiya urovnya vitamina D so stepen’yu tyazhesti i sensibilizatsiei k allergenam pri atopicheskom dermatite u detei 3–6 let. Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics). 2021;66(4):185. (In Russ).
73. Ibrahim HM, El-Taieb MA, Hassan MH, et al. Relations between vitamin D3, total and specific IgE for house dust mites in atopic dermatitis patients. Sci Rep. 2020;10(1):21000. doi: https://doi.org/10.1038/s41598-020-77968-1
74. Jang YH, Sim HB, Moon SY, Lee WJ, Lee SJ, Jin M, Kim SH, Kim DW. House Dust Mite Sensitization Is Inversely Associated with Plasma 25-Hydroxyvitamin D3 Levels in Patients with Severe Atopic Dermatitis. Ann Dermatol. 2017;29(4):400–406. doi: https://doi.org/10.5021/ad.2017.29.4.400
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For citations:
Kashinskaya T.S., Shakhova N.V., Lobanov Y.F., Kamaltynova E.M. Prevalence of Vitamin D Insufficiency/Deficiency and Their Role in Atopic Dermatitis Development and Course in Children. Current Pediatrics. 2022;21(4):305-310. (In Russ.) https://doi.org/10.15690/vsp.v21i4.2435
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