Papulopustular Acne: Differential Diagnosis and Therapy Algorithms in Prepubertal and Pubertal Age
https://doi.org/10.15690/vsp.v22i5.2639
Abstract
Acne is chronic inflammatory skin disease. Its examination and management tactics depend on the patient's age and disease clinical form. This article presents treatment algorithms for acne vulgaris in adolescent and pre-adolescent children and describes clinical cases.
About the Authors
Nikolay N. MurashkinRussian Federation
Moscow
Disclosure of interest:
receiving research grants from pharmaceutical companies Jansen, Eli Lilly, Novartis. Receiving fees for scientific counseling from companies Galderna, Pierre Fabre, Bayer, Leopharma, Pfizer, AbbVie, Amryt Pharma, Celgene, Mölnlycke Health Care AB, Zeldis Pharma
Maria A. Leonova
Russian Federation
Moscow
Disclosure of interest:
Other authors confirmed the absence of a reportable conflict of interests
Leonid A. Opryatin
Russian Federation
Moscow
Disclosure of interest:
receiving fees for scientific counseling from companies Eli Lilly, Jansen
Alexander I. Materikin
Russian Federation
Moscow
Disclosure of interest:
receiving research grants from pharmaceutical companies Eli Lilly, Novartis, AbbVie, Amryt Pharma, Jansen, Pfizer, Celgene. Receiving fees for scientific counseling from company Mölnlycke Health Care AB
Roman V. Epishev
Russian Federation
Moscow
Disclosure of interest:
receiving research grants from pharmaceutical companies Eli Lilly, Novartis, AbbVie, Amryt Pharma, Jansen, Pfizer, Celgene. Receiving fees for scientific counseling from company Mölnlycke Health Care AB
Dmitri V. Fedorov
Russian Federation
Moscow
Disclosure of interest:
Other authors confirmed the absence of a reportable conflict of interests
References
1. Araviiskaia ER, Murashkin NN, Namazova-Baranova LS, Ivanov RA. Modern Outlooks on Pathogenesis, Clinical Picture, Diagnosis and Management of Acne Vulgaris in Children and Adolescents. Voprosy sovremennoi pediatrii — Current Pediatrics. 2020;19(6):408–419. (In Russ). doi: https://doi.org/10.15690/vsp.v19i6.2141
2. Dreno B, Pecastaings S, Corvec S, et al. Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. J Eur Acad Dermatol Venereol. 2018;32 Suppl 2: 5–14. doi: https://doi.org/10.1111/jdv.15043
3. O’Neill A, Gallo R. Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris. Microbiome. 2018;6(1):177. doi: https://doi.org/10.1186/s40168-018-0558-5
4. Bolezni kozhi. Infektsii, peredavaemye polovym putem: Federal clinical guidelines. 5th ed., rev. and add. Moscow: Delovoi ekspress; 2016. 768 p. (In Russ). Доступно по: http://www.cnikvi.ru/docs/2335_maket_30.pdf. Ссылка активна на 22.09.2023.
5. Araviiskaia ER, Samtsov AV, Sokolovskiy EV, et al. Revisiting the question of assessment by severity and classification of acne. Vestnik Dermatologii i Venerologii. 2022;98(6):48–54. (In Russ). doi: https://doi.org/10.25208/vdv1374
6. Akne vul’garnye: Federal clinical guidelines. Russian Society of Dermatovenereologists and Cosmetologists; 2020. 33 p. Доступно по: https://www.cnikvi.ru/docs/clinic_recs/klinicheskierekomendatsii-2019-2020/files/КР Акне 2020.docx. Ссылка активна на 22.09.2023.
7. Thiboutot DM, Dreno B, Abanmi A, et al. Practical management of acne for clinicians: an international consensus from Global Alliance to improve outcomes in acne. J Am Acad Dermatol. 2018;78(2 Suppl 1):S1–S23. doi: https://doi.org/10.1016/j.jaad.2017.09.078
8. Nast A, Dréno B, Bettoli V, et al. European evidence-based (S3) guideline for the treatment of acne — update 2016 — short version. J Eur Acad Dermatol Venereol. 2016;30(8):1261–1268. doi: https://doi.org/10.1111/jdv.13776
9. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74(5): 945–973.e33. doi: https://doi.org/10.1016/j.jaad.2015.12.037
10. Samtsov AV, Araviiskaya ER. Federal’nye klinicheskie rekomendatsii po vedeniyu bol’nykh akne. Moscow: Russian Society of Dermatovenereologists and Cosmetologists; 2013. (In Russ).
11. Paller AS, Mancini AJ. Hurwitz Clinical Pediatric Dermatology E-Book: A Textbook of Skin Disorders of Childhood and Adolescence. 5th ed. Elsevier Health Sciences; 2015. p. 176.
12. Eichenfield LF, Krakowski AC, Piggott C, et al. Evidencebased recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013;131 Suppl 3:S163–S186. doi: https://doi.org/10.1542/peds.2013-0490B
13. Williams HC, Dellavalle RP, Garner S. Acne vulgaris. Lancet. 2012;379(9813):361–372. doi: https://doi.org/10.1016/S01406736(11)60321-8
14. Hafsi W, Arnold DL, Kassardjian M. Acne Conglobata. 2023 Jan 13. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023.
15. Fabbrocini G, Annunziata MC, D’Arco V, et al. Acne scars: pathogenesis, classification and treatment. Dermatol Res Pract. 2010;2010:893080. doi: https://doi.org/10.1155/2010/893080
16. Dreno B, Layton A, Zouboulis C, et al. Adult female acne: a new paradigm. J Eur Acad Dermatol Venereol. 2013;27(9):1063–1070. doi: https://doi.org/10.1111/jdv.12061
17. Cantatore-Francis JL, Glick SA. Childhood acne: evaluation and management. Dermatol Ther. 2006;19(4):202–209. doi: https://doi.org/10.1111/j.1529-8019.2006.00076.x
18. Nosachyova OA, Torshkhoeva RM, Torshkhoeva RM. Modern Methods of Acne Treatment in Children. Pediatricheskaya farmakologiya — Pediatric pharmacology. 2013;10(5):23–30. (In Russ). doi: https://doi.org/10.15690/pf.v10i5.819
19. Araviiskaia E, Dréno B. The role of topical dermocosmetics in acne vulgaris. J Eur Acad Dermatol Venereol. 2016;30(6):926–935. doi: https://doi.org/10.1111/jdv.13579
20. Nosachyova OA, Namazova-Baranova LS, Torshkhoeva RM, Gevorkyan AK. Modern Cosmetic Product for Acne Therapy in Children. Pediatricheskaya farmakologiya — Pediatric pharmacology. 2013;10(5):80–85. (In Russ). doi: https://doi.org/10.15690/pf.v10i5.828
21. Rosen T. Antibiotic resistance: an editorial review with recommendations. J Drugs Dermatol. 2011;10(7):724–733.
22. Kircik LH. Re-evaluating treatment targets in acne vulgaris: adapting to a new understanding of pathophysiology. J Drugs Dermatol. 2014;13(6):s57–s60.
23. Thielitz A, Abdel-Naser MB, Fluhr JW, et al. Topical retinoids in acne — an evidenc;e-based overview. J Dtsch Dermatol Ges. 2008;6(12):1023–1031. doi: https://doi.org/10.1111/j.1610-0387.2008.06741.x
24. Czernielewski J, Michel S, Bouclier M, et al. Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne. J Eur Acad Dermatol Venereol. 2001;15(Suppl 3):5–12. doi: https://doi.org/10.1046/j.0926-9959.2001.00006.x
25. Tan J, Gollnick HP, Loesche C, et al. Synergistic efficacy of adapalene 0.1%-benzoyl peroxide 2.5% in the treatment of 3855 acne vulgaris patients. J Dermatolog Treat. 2011;22(4):197–205. doi: https://doi.org/10.3109/09546631003681094
26. Gollnick HPM, Funke G, Kors C, et al. Efficacy of adapalene/ benzoyl peroxide combination in moderate inflammatory acne and its impact on patient adherence. J Dtsch Dermatol Ges. 2015;13(9):969. doi: https://doi.org/10.1111/ddg.12613
27. Dreno B, Bissonnette R, Gagne-Henley A, et al. Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/ Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, VehicleControlled Trial Using Intra-Individual Comparison. Am J Clin Dermatol. 2018;19(2):275–286. doi: https://doi.org/10.1007/s40257-018-0352-y
28. Bettoli V, Borghi A, Zauli S, et al. Maintenance Therapy for Acne Vulgaris: Efficacy of a 12-Month Treatment with Adapalene-Benzoyl Peroxide after Oral Isotretinoin and a Review of the Literature. Dermatology. 2013;227(2):97–102. doi: https://doi.org/10.1159/000350820
29. Poulin Y, Sanchez NP, Bucko A, et al. A 6-month maintenance therapy with adapalene-benzoyl peroxide gel prevents relapse and continuously improves efficacy among patients with severe acne vulgaris: results of a randomized controlled trial. Br J Dermatol. 2011;164(6):1376–1382. doi: https://doi.org/10.1111/j.13652133.2011.10344.x
30. Goldsmith LA, Bolognia JL, Callen JP, et al. American Academy of Dermatology. American Academy of Dermatology Consensus Conference on the safe and optimal use of isotretinoin: summary and recommendations. J Am Acad Dermatol. 2004;50(6):900–906. doi: https://doi.org/10.1016/j.jaad.2004.02.012
Review
For citations:
Murashkin N.N., Leonova M.A., Opryatin L.A., Materikin A.I., Epishev R.V., Fedorov D.V. Papulopustular Acne: Differential Diagnosis and Therapy Algorithms in Prepubertal and Pubertal Age. Current Pediatrics. 2023;22(5):393-399. (In Russ.) https://doi.org/10.15690/vsp.v22i5.2639