Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review
https://doi.org/10.15690/vsp.v23i2.2722
Abstract
The pathogenesis of inflammatory bowel diseases still remains unclear nowadays. Genetic disposition, impaired immune regulation, disturbance in intestinal microbiota composition, exposure to environmental factors are associated with the development of inflammation in intestinal mucosa and increased epithelial penetrance that define disease's development and progression. There is a theory in scientific literature that vitamin D deficiency (among other environmental factors) increases the risk of inflammatory bowel disease. However, the role of vitamin D in the development of gastrointestinal tract diseases remains poorly studied. This article presents current data on the vitamin D effect on the intestinal mucosa barrier function, on the immune system and on the intestinal microbiota in the context of inflammatory bowel diseases pathogenesis.
Supporting agencies: Not specified.
About the Authors
Anatoly I. Khavkin
Research and Clinical Institute for Children; Belgorod State University
Russian Federation
Disclosure of interest:
Russian Federation
Moscow; Belgorod
Disclosure of interest:
None
Andrew V. Nalyotov
Donetsk State Medical University named after M. Gorky
Russian Federation
Disclosure of interest:
Russian Federation
Donetsk
Disclosure of interest:
None
Dmitry I. Masyuta
Donetsk State Medical University named after M. Gorky
Russian Federation
Disclosure of interest:
Russian Federation
Donetsk
Disclosure of interest:
None
Ravil F. Makhmutov
Donetsk State Medical University named after M. Gorky
Russian Federation
Disclosure of interest:
Russian Federation
Donetsk
Disclosure of interest:
None
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Review
For citations:
Khavkin A.I., Nalyotov A.V., Masyuta D.I., Makhmutov R.F. Role of Vitamin D in the Pathogenesis of Inflammatory Bowel Diseases: Literature Review. Current Pediatrics. 2024;23(2):58-62. (In Russ.) https://doi.org/10.15690/vsp.v23i2.2722
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