The Role of Systemic Inflammation in Psychiatric Disorders Development in Children: Literature Review
https://doi.org/10.15690/vsp.v23i4.2780
Abstract
There has been significant increase in mental disorders prevalence in pediatric population around the world. Increasing incidence of autism, intellectual incapacity, hyperkinetic disorders, and schizophrenia gives causes for specific concern. Clarifying mental disorders’ etiology and pathogenesis is the priority of researchers. The role of systemic inflammation in psychiatric disorders development currently remains the least studied. However, it can already be stated that generalized peripheral inflammation is the important factor associated with the development of mental disorders both in adults and children. This review presents latest data, as well as an authors’ assessment of systemic inflammation role in the most common mental disorders development in children. Comparative analysis of acute and chronic systemic inflammation manifestations has been performed. The major pathogenetic mechanisms of “systemic damage” in mental disorders have been identified.
Keywords
children,
systemic inflammation,
cytokines,
hematological indices,
autism,
mental retardation,
attention deficit and hyperactivity disorder,
schizophrenia
Supporting agencies: The study was carried out within the national assignment of National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev of the Ministry of Health of Russian Federation for 2024-2026 (XSOZ 2024 0012).
About the Authors
Daria A. Emelina
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev
Russian Federation
Disclosure of interest:
Russian Federation
Saint Petersburg
Disclosure of interest:
Not declared.
Ilya V. Kravchenko
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev
Russian Federation
Disclosure of interest:
Russian Federation
Saint Petersburg
Disclosure of interest:
Not declared.
Igor V. Makarov
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev
Russian Federation
Disclosure of interest:
Russian Federation
Saint Petersburg
Disclosure of interest:
Not declared.
Rauf F. Gasanov
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev
Russian Federation
Disclosure of interest:
Russian Federation
Saint Petersburg
Disclosure of interest:
Not declared.
Ekaterina S. Prokhorenko
National Medical Research Center for Psychiatry and Neurology named after V.M. Bekhterev
Russian Federation
Disclosure of interest:
Russian Federation
Saint Petersburg
Disclosure of interest:
Not declared.
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For citations:
Emelina D.A., Kravchenko I.V., Makarov I.V., Gasanov R.F., Prokhorenko E.S. The Role of Systemic Inflammation in Psychiatric Disorders Development in Children: Literature Review. Current Pediatrics. 2024;23(4):204-212. (In Russ.) https://doi.org/10.15690/vsp.v23i4.2780
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