Outcomes of Antibiotic Therapy During Perinatal Period for the Early Age Child’s Intestinal Microbiota
Irina A. Belyaeva,
Leyla S. Namazova-Baranova,
Elena P. Bombardirova,
Tatyana V. Turti,
Regina A. Shukenbayeva https://doi.org/10.15690/vsp.v23i6.2822
Abstract
This literature review provides data on antibiotic therapy (AT) consequences that child may be exposed during the perinatal period considering the development of the most crucial body system — intestinal microbiota. The main characteristics of the intestinal microbiota disturbance in infants due to various AT exposure time and volume are presented. Moreover, antibiotics' effects on the intestinal microbiota development in full-term and premature babies are covered. Modern data on the development of pathobionts and symbionts resistome within intestinal microbiota in «mother-child» complex and variants of vertical (from mother to child) and horizontal (between microorganisms) transmission of antibiotic resistance genes are presented. The major strategies for minimizing the negative consequences of perinatal AT are described
Keywords
perinatal period,
newborns,
antibiotics,
intestinal microbiota,
resistome,
breast feeding,
probiotics
Supporting agencies: Not specified.
About the Authors
Irina A. Belyaeva
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Morozovskaya Children’s City Hospital
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Irina A. Belyayeva — lecturing for pharmaceutical
companies Progress, Akrikhin, Bayer, AstraZeneca, Abbott
Laboratories.
Leyla S. Namazova-Baranova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Leyla S.Namazova-Baranova — receiving research
grants from pharmaceutical companies Pierre Fabre,
Genzyme Europe B. V., Astra Zeneca PLC, Gilead / PRA
“Pharmaceutical Research Associates CIS”, Teva Branded
Pharmaceutical products R&D, Inc / “PPD Development
(Smolensk)” LLC, “Stallerzhen S.A.” / “Quintiles GMBH”
(Austria).
Elena P. Bombardirova
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Author confirmed the absence of a reportable
conflict of interests.
Tatyana V. Turti
Research Institute of Pediatrics and Children’s Health in Petrovsky National Research Centre of Surgery; Pirogov Russian National Research Medical University; Research Institute for Healthcare Organization and Medical Management
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Tatyana V. Turti — lecturing for pharmaceutical companies Progress, Akrikhin.
Regina A. Shukenbayeva
Pirogov Russian National Research Medical University
Russian Federation
Disclosure of interest:
Russian Federation
Moscow
Disclosure of interest:
Author confirmed the absence of a reportable
conflict of interests.
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Belyaeva I.A., Namazova-Baranova L.S., Bombardirova E.P., Turti T.V., Shukenbayeva R.A. Outcomes of Antibiotic Therapy During Perinatal Period for the Early Age Child’s Intestinal Microbiota. Current Pediatrics. 2024;23(6):447-455. (In Russ.) https://doi.org/10.15690/vsp.v23i6.2822
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