EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY
https://doi.org/10.15690/vsp.v12i1.578
Abstract
One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Fecal elastase 1 is a good marker of pancreatic exocrine secretion. The aim of the study was to evaluate the pancreatic exocrine secretion in children with type 1 diabetes mellitus with fecal elastase 1 test to estimate the possible need for exogenous pancreatic enzyme replacement therapy. The exocrine pancreatic function was evaluated in 54 diabetic children on the basis of steatocrite test and a determination of fecal elastase 1 concentrations. Compared to the controls, the diabetic children had significantly lower levels of fecal elastase 1 concentration (p<0,001). Steatorrhoea was registered in all patients with fecal elastase 1 level < 200 µg/g stool. All those patients were treated with pancreatin (creon) for 1 month. A reduction of fat excretion was observed in the pancreatin treated group at the end of the study. Pancreatin replacement therapy can be used safely in children with type 1 diabetes mellitus associated with exocrine pancreatic insufficiency.
About the Authors
A. A. Nizhevich
Bashkir State Medical University, the Republic of Bashkortostan
Russian Federation
Russian Federation
G. M. Yakupova
Children’s Republican Hospital, Ufa, the Republic of Bashkortostan
Russian Federation
Russian Federation
O. A. Malievskii
Bashkir State Medical University, the Republic of Bashkortostan
Russian Federation
Russian Federation
E. N. Akhmadeeva
Bashkir State Medical University, the Republic of Bashkortostan
Russian Federation
Russian Federation
A. M. Farkhutdinova
Children’s Republican Hospital, Ufa, the Republic of Bashkortostan
Russian Federation
Russian Federation
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Review
For citations:
Nizhevich A.A., Yakupova G.M., Malievskii O.A., Akhmadeeva E.N., Farkhutdinova A.M. EXOCRINE PANCREATIC INSUFFICIENCY IN CHILDREN WITH TYPE 1 DIABETES MELLITUS: A NEW PROBLEM OF PEDIATRIC GASTROENTEROLOGY. Current Pediatrics. 2013;12(1):181-185. (In Russ.) https://doi.org/10.15690/vsp.v12i1.578
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