MELATONIN SECRETION AND HYPERSOMNIA IN CHILDREN AND ADOLESCENTS AFTER CRANIOPHARYNGIOMA RESECTION
https://doi.org/10.15690/vsp.v11i5.423
Abstract
Craniopharyngioma is a rare embryonic tumor of the chiasm-sellar region with low malignancy rate but high frequency of recurrence. In spite of the favorable outcome and satisfactory results of treatment the patients quality of life worsens due to complications associated with anatomic localization of craniopharyngioma close to the optic nerve, optic chiasm, hypophysis and hypothalamus. The development of hypothalamic obesity is observed in 25–60% of children and adolescents after surgical treatment of craniopharyngioma, which is usually accompanied with significant disturbances of circadian rhythm and has the most important influence on patients quality of life.
About the Authors
E. Yu. Il'ina
I.M. Sechenov First Moscow State Medical University,
Russian Federation
Russian Federation
N. A. Strebkova
Institute of Pediatric Endocrinology of the FSFI ESC, Moscow
Russian Federation
Russian Federation
V. A. Peterkova
Institute of Pediatric Endocrinology of the FSFI ESC, Moscow, Russian Federation
Russian Federation
Russian Federation
References
1. Muller H. L., Kaatsch P., Warmuth-Metz M. et al. Childhood craniopharyngioma — diagnostic and therapeutic strategies. Monatsschr. Kinderheilkunde. 2003; 151: 1056–1063.
2. Muller H. L. et al. Childhood craniopharyngioma. Recent advances in diagnosis, treatment and follow-up. Horm. Res. 2008; 69: 193–202.
3. Muller H. L. et al. Childhood craniopharyngioma: current strategies in laboratory diagnostics and endocrine treatment. Lab. Med. 2003; 27: 377–385.
4. Fahlbusch R., Honegger J., Paulus W. et al. Surgical management of craniopharyngiomas: experience with 168 patients. J. Neuro surg. 1999; 90: 237–250.
5. Muller H. L., Bueb K., Bartels U. et al. Obesity after childhood craniopharyngioma — German multicenter study on preoperative risk factors and quality of life. Klin. Padiatr. 2001; 213: 244–249. Medline. doi:10.1055/s-2001-16855.
6. Brzezinski A. et al. Melatonin in humans. N. Eng. J. Med. 1997; 336 (3): 186–195.
7. Hardeland R. et al. Melatonin, hormone of darkness and more — occurrence, control mechanisms, actions, and bioactive metabolites. Cell. Mol. Life Sci. 2008; 65 (13): 2001–2018.
8. Muller H. L., Handwerker G., Wollny B. et al. Melatonin secretion and increased daytime sleepiness in childhood craniopharyngioma patients. J. Clin. Endocrinol. Metab. 2002; 87 (8): 3993–3996.
9. Muller H. L., Handwerker G., Gebhardt U. et al. Melatonin treatment in obese patients with childhood craniopharyngioma and increased daytime sleepiness. Cancer Causes Control. 2006; 17 (4): 583–589.
10. Lin L., Faraco J., Li R. et al. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell. 1999; 98 (3): 365–376.
11. Chemelli R. M., Willie J. T., Sinton C. M. et al. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999; 98 (4): 437–451.
12. Nishino S., Ripley B., Overeem S. et al. Hypocretin (orexin) deficiency in human narcolepsy. Lancet. 2000; 355 (9197): 39–40.
13. Krahn L. E., Boeve B. F., Oliver L., Silber M. H. Hypocretin (orexin) and melatonin values in a narcoleptic- like sleep disorder after pinealectomy. Sleep Medicine. 2002; 3 (6): 521–523.
14. Marcus C. L., Trescher W. H., Halbower A. C., Lutz J. Secondary narcolepsy in children with brain tumors. Sleep. 2002; 25 (4): 435–439.
15. Laakso M. L., Porkka-Heiskanen T., Alila A. et al. Correlation between salivary and serum melatonin: dependence on serum melatonin levels. J. Pineal. Res. 1990; 9: 39–50.
16. Bloch K. E., Schoch O. D., Zhang J. N., Russi E. W. German version of the Epworth Sleepiness Scale. Respiration. 1999; 66: 440–447.
Review
For citations:
Il'ina E.Yu., Strebkova N.A., Peterkova V.A. MELATONIN SECRETION AND HYPERSOMNIA IN CHILDREN AND ADOLESCENTS AFTER CRANIOPHARYNGIOMA RESECTION. Current Pediatrics. 2012;11(5):19-23. (In Russ.) https://doi.org/10.15690/vsp.v11i5.423
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