OSMOTIC LAXATIVES IN TREATMENT OF CHRONIC CONSTIPATIONS IN CHILDREN
https://doi.org/10.15690/vsp.v11i5.445
Abstract
A comparative trial including 80 patients at the age of 1–16 years old was performed in order to evaluate efficacy and safety of osmotic laxatives polyethylene glycol with molecular mass of 4000 kDa and lactulose (46 children received polyethylene glycol, 34 — lactulose) in children with chronic functional constipations. The observation period during the treatment lasted for 2 weeks, clinical and laboratory evaluation of the therapy efficacy and safety was carried out. The normalization of stool was achieved on the average in 3 days of treatment in both groups, pain and dyspepsia were arrested in the majority of the patients. Stool consistency was normalized. No side-effects were registered. However in the first days of lactulose treatment there were reliably more complaints on flatulence and rumbling, which passed spontaneously. Lactulose and polyethylene glycol were shown to be effective and safe in treatment of chronic functional constipations in children and can be recommended for usage even in infants.
Keywords: children, constipations, lactulose.
About the Authors
E. A. Kornienko
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
K. M. Komarov
Children Municipal Hospital № 22, St. Petersburg
Russian Federation
Russian Federation
M. Yu. Tipikina
N.F. Filatov Children Clinical Hospital № 5, St. Petersburg
Russian Federation
Russian Federation
T. B. Loboda
St. Petersburg State Pediatric Medical University
Russian Federation
Russian Federation
References
1. Talley N. Y., Jones M., Nuyts G., Dubois D. Risk factors for chronic constipation based on a general practice sample. Am. J. Gastroentrol. 2003; 98: 1107–1111.
2. Cheng C., Chan A. O., Hui W. M., Lam S. K. Coping strategies, illness perception, anxiety and depression of patients with idiopatic constipation: a population-based study. Aliment. Pharmacol. Ther. 2003; 18: 319–326.
3. Loening-Baucke V. Chronic constipation in children. Gastroenterology. 1993; 105: 1557–1564.
4. Di Lorenzo C., Flores A. F., Reddy S. N., Hyman P. E. Use of colonic manometry to differentiate causes of intractable constipation in children. J. Pediatr. 1992; 120: 690–695.
5. Xing J. H., Soffer E. E. Adverse effects of laxatives. Dis. Colon. Rectum. 2001; 44: 1201–1209.
6. Di Palma J. A., De Ridder P. H., Orlando R. C. A randomized placebo controlled multicentre study of the safety and efficacy of a new polyethylene glycol laxative. Am. J. Gastroenterol. 2000; 95: 446–450.
7. Dupont C., Ammar F., Leluyer B., Mathiex-Fortunet H., Garnier P. Polyethylene glycol (PEG) in constipating children: a dose deter mination study. Gastroenterology. 2000; 18 (2): 846.
8. Dupont C., Leluyer B., Maamri N., Morali A. Double-blind randomized evaluation of clinical and biological tolerance of polyethylene glycol in constipated children. J. Pediatr. Gastroenterol. Nutr. 2005; 41: 625–633.
9. Carraziari E., Badiali D., Bazzocchi G. Long term efficacy, safety and tolerability of low doses of isosmotic polyethylene glycol electrolyte balanced solution in the treatment of functional chronic constipation. Gut. 2000; 46: 522–526.
10. Autret E., Vasmant D. Determination of drug posology in pediatrics. Therapie. 1995; 50: 381–386.
11. Attar A., Lemann M., Ferguson A. Comparison of a low dose polyethylene glycol electrolyte solution with lactulose for treatment of chronic constipation. Gut. 1999; 44: 226–230.
Review
For citations:
Kornienko E.A., Komarov K.M., Tipikina M.Yu., Loboda T.B. OSMOTIC LAXATIVES IN TREATMENT OF CHRONIC CONSTIPATIONS IN CHILDREN. Current Pediatrics. 2012;11(5):152-155. (In Russ.) https://doi.org/10.15690/vsp.v11i5.445
Views:
827
Email this article 
