SEROLOGICAL MARKERS OF CELIAC DISEASE AND HLA II ANTIGENS IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS TYPE 1
https://doi.org/10.15690/vsp.v11i1.128
Abstract
We have studied incidenceof immunological markers of celiac disease in children with diabetes mellitus type 1 (DM1) and their correlation with clinical peculiarities and polymorphous alleles of HLA. It was shown that incidence of celiac markers is higher in DM1 children than in general population and makes up 7.4%. Patients who were seropositive with celiac antigens had gastrointestinal symptoms and iron deficiency more often. The occurrence rate of other autoimmune disorders in seropositive patients was 24%, with high count of autoantibodies towards transglutaminase (AbTT) — 50%. More than 78% of seroposetive patients possessed haplotypes DQ2 and|or DQ8 HLA. The occurrence rate was identical. In patients with high AbTT occurrence of HLA genotypes with DQ2 and/or DQ8 rose up to 100%.
About the Authors
E. O. Hennesy
Scientific Endocrinological Centre, Moscow
Russian Federation
postgraduate student of the Institute of Child Endocrinology of FSBI “Endocrinologic Scientific Center”
Russian Federation
postgraduate student of the Institute of Child Endocrinology of FSBI “Endocrinologic Scientific Center”
T. L. Kuraeva
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
S. A. Prokofyev
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
N. B. Smirnova
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
Y. V. Tishina
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
E. V. Тitovic
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
V. A. Peterkova
Scientific Endocrinological Centre, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Hennesy E.O., Kuraeva T.L., Prokofyev S.A., Smirnova N.B., Tishina Y.V., Тitovic E.V., Peterkova V.A. SEROLOGICAL MARKERS OF CELIAC DISEASE AND HLA II ANTIGENS IN CHILDREN AND ADOLESCENTS WITH DIABETES MELLITUS TYPE 1. Current Pediatrics. 2012;11(1):14-17. (In Russ.) https://doi.org/10.15690/vsp.v11i1.128
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