AZITROMYCIN EFFICACY IN TREATMENT OF PEDIATRIC OUT-OF-HOSPITAL INFECTIONS
https://doi.org/10.15690/vsp.v11i1.132
Abstract
Macrolides remain one of the most popular types of antibiotics prescribed in the outpatient’s clinic and also are second most popular after penicillins in the amount of consumption. Activity against the majority of respiratory pathogens, including atypical ones, high tolerability, presence of special nonantimicrobal features that are unique for medications of this class — all this make them a favourable choice for bacterial out-of-hospital infections treatment. This article contains comparative analysis of drugs of this class. The role of azithromycin in pediatric respiratory out-of-hospital infections treatment is discussed.
About the Author
L. V. Kozlova
Children’s Clinical Hospital, Smolensk
Russian Federation
Lyudmila Vyacheslavovna Kozlova, PhD, professor, Honoured Scientist of RF, Honoured Doctor of RF, Head of the Department № 1 of Child Clinical Hospital
Russian Federation
Lyudmila Vyacheslavovna Kozlova, PhD, professor, Honoured Scientist of RF, Honoured Doctor of RF, Head of the Department № 1 of Child Clinical Hospital
References
1. Кешишян Е. С., Семина Г. Ю. Оценка клинической эффективности препарата «Зитроцин» в лечении различных инфекционно-воспалительных заболеваний у детей // Вестник педиатрической фармакологии и нутрициологии. — 2007; 4 (5): 35–39.
2. Гаращенко Т. И. Макролиды в терапии острого тонзиллита и его осложнений у детей // РМЖ. — 2001; 9 (19): 812–816.
3. Жаркова Л. П. Азитромицин: что нужно знать педиатру // Фарматека. — 2007; 17 (151): 31–37.
4. Esposito S., Bosis S., Faelli N. et al. Role of atypical bacteria and azithromycin therapy for children with recurrent respiratory tract infections // Pediatr. Infect. Dis. J. — 2005; 24 (5): 438–444.
5. Girard A., Cimochowski C., Faiella J. Correlation of increased azithromycin concentrations with phagocyte infiltration into sites of localized infection // J. Antimicrob. Chemother. — 1996; 37 (Suppl. C): 9–19.
6. Страчунский Л. С., Козлов С. Н. Макролиды в современной клинической практике. 15-членные препараты — Азалиды. — Смоленск: Русич, 1998.
7. Prescott W., Johnson C. Antiinflammatory therapies for cystic fibrosis, past, present, and future // Pharmacotherapy. — 2005; 25 (4): 555–573.
8. Карпов О. И. Макролиды как антивоспалительные агенты // Consilium medicum. — 2006; 8 (10).
9. Girard D., Finegan S. M., Dunne M. W., Lame M. E. Enhanced efficacy of single-dose versus multi-dose azithromycin regimens in preclinical infection models // J. Antimicrob Chemother. — 2005; 56 (2): 365–371.
10. Харламова Ф. С., Богомильский М. Р., Гаращенко Т. И. и соавт. Короткие курсы азитромицина в лечении осложненных форм острых респираторных заболеваний у детей / Пособие для врачей. — М.: МЗ РФ, 2004.
11. Ruuskanen O. Safety and tolerability of azithromycin in pediatric infectious diseases, 2003 update // Pediatr. Infect. Dis. J. — 2004; 23 (S): 135–139.
12. Treadway G., Reisman A. Tolerability of 3-ay, once-daily azithromycin suspension versus standard treatments for communityacquired paediatric infectious diseases // Int. J. Antimicrob. Agents. — 2001; 18 (5): 427–431.
13. Treadway G., Pontani D. Paediatric safety of azithromycin, worldwide experience // J. Antimicrob. Chemother. — 1996; 37 (Suppl. C): 143–149.
14. Pichichero M. E. Acute otitis media: part 2 Treatment in an era of increasing antibiotic resistance // Ann. Fam. Phisician. — 2000; 61: 2416.
15. Lauvau D. V., Verbist L. An open, multicentre, comparative study of the efficacy and tract infections in children. The Paediatric Azithromycin Study Group // J. Int. Med. Res. — 1997; 25 (5): 285–295.
16. Principi N., Esposito S., Blasi F. et al. Mycoplasma pneumoniae and Clamydia pneumoniae in children with community-acquired pneumonia lower respiratory tract infections // Clin. Infect. Dis. — 2001; 32: 1281–1289.
17. Запруднов А. М., Мазанкова Л. Н., Григорьев К. И. Новые макролиды в педиатрии. Библиотека практического врача (Акту альные вопросы современной медицины). — М., 1998. — 48 с.
18. Jacobs R., Schutze G., Yong R. Principles and practice of pediatric infectious diseases. — NY, 1997. — Р. 1604–1662.
19. Matsunaga T. Pharmacological and pharmacokinetic properties of azithromycin, a novel 15-membered ring macrolide antibacterial agent // Nippon Yakuhgaku Zasshi. — 2001; 117 (5): 343–349.
20. Pucander J., Rautianen M. Penetration of azithromycin into middle ear effusion in acute and secretory otitis media in children // J. Antimicrob Chemother. — 1996; 37 (Suppl. C): 53–61.
21. Козлов Р. С., Сивая О. В., Кречикова О. И. и соавт. Динамика резистентности Streptococcus pneumoniae к антибиотикам в России за период 1999–2009 гг. // Клин. Микробиол. антимикробная химиотерапия. — 2010; 12 (4): 329–341.
22. Котлуков В. К., Кузьменко Л. Г. Рациональная антибиотикотерапия инфекций дыхательных путей и ЛОР-органов у детей в амбулаторной практике педиатра // Педиатрия. — 2008; 87 (6): 110–115.
23. Principi N., Esposito S., Cavagna R. et al. Recurrent respiratory tract infections in pediatric age, a population-based survey of the therapeutic role of macrolides // J. Chemother. — 2003; 15 (1): 53–59.
24. Langley J., Halperin S., Boucher F. et al. Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis // Pediatrics. — 2004; 114: 96–101.
25. Wolter J., Seeney S., Bell S. et al. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis, a randomised trial // Thorax. — 2002; 57 (3): 212–216.
Review
For citations:
Kozlova L.V. AZITROMYCIN EFFICACY IN TREATMENT OF PEDIATRIC OUT-OF-HOSPITAL INFECTIONS. Current Pediatrics. 2012;11(1):51-55. (In Russ.) https://doi.org/10.15690/vsp.v11i1.132
Views:
911
Email this article 
